The invention provides an intelligent and efficient heat supply network operation adjusting method which comprises the steps of 1, conducting hydraulic adjustment on a secondary network, so that the hydraulic balance of the secondary network is achieved; 2, on the basis of the hydraulic balance of the secondary network, conducting hydraulic adjustment on a primary network, so that the hydraulic balance of the primary network is achieved; 3, on the basis of the hydraulic balance of the heat supply network side, respectively conducting thermal adjustment on the heat supply initial station and all heat exchange stations, so that the thermal balance is achieved; and 4, on the basis of the hydraulic and thermal balance of the heat supply network side, predicting a heat load of the heat supply network side, optimizing the configuration of the heat source side according to the prediction result of the heat load of the heat supply network side, and adaptively adjusting the output of the heat source side to realize the cooperative adjustment between the network and the source. According to the intelligent and efficient heat supply network operation adjusting method provided by the invention, adjustment difficulty caused by strong coupling and large lagging of a heat supply network can be effectively relieved, the hydraulic adjustment work efficiency is greatly improved, the overall dispatching coordination capacity of the heat supply system is improved, heat insufficiency or excess of the heat supply system is avoided, heat supply of the heat supply system according to needs is achieved, and on the premise that the heat supply quality is guaranteed, heat supply energy consumption is reduced, and the survival pressure of heat supply enterprises is reduced.