The invention discloses a medicine grinding device dedicated to a general surgery department. The medicine grinding device comprises a bottom plate, a supporting plate, a rotating device, a motor device, a feeding device and a grinding device, wherein first supporting rods and material receiving boxes are arranged on the bottom plate; a first through hole, a first supporting ring, a locating ring and a first grinding ring are arranged on the supporting plate; the rotating device comprises a second grinding ring, a material pouring ring, a gear, a first rotating shaft and a first motor; the motor device comprises a second motor, a second rotating shaft and a rotary disc; the feeding device comprises a first bracket, a feed hopper and a feeding tube; and the grinding device comprises a third grinding ring, a baffle ring, a second bracket, springs and rotating wheels. According to the medicine grinding device, medicine can be fully grinded, the grinding effect is relatively good, patients can conveniently take medicine, the noise is relatively low, the rest of patients is not influenced, the medicine can be directly grinded, an additional plane is not required to be found, and the utilization convenience is improved.