The invention discloses a super-hydrophilic low-molecular-weight intercepted graphene composite ultrafiltration membrane and a manufacturing method of the super-hydrophilic low-molecular-weight intercepted graphene composite ultrafiltration membrane. The composite ultrafiltration membrane comprises graphene oxide, a polysulfone ultrafiltration membrane prepared by blending the graphene oxide, aminated titanium dioxide nanoparticles implanted into the surface of a polysulfone ultrafiltration pore channel, N-methylpyrrolidone, polyvinylpyrrolidone, polyvinylpyrrolidone, polyvinylidene fluoride, hydrazine hydrate and ammonia water. Compared with an ultrafiltration membrane without doped graphene, the ultrafiltration membrane with higher mass fraction of doped graphene has better mechanical property and swelling resistance, high tensile strength, large water flux and high bovine serum albumin rejection rate, the interaction between organic frameworks is enhanced, the mechanical strength of the organic frameworks is greatly enhanced, the mechanical property of the prepared ultrafiltration membrane is obviously improved, the solvent resistance of the membrane is greatly enhanced, and a remarkable technical effect is achieved.