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Lomefloxacin eye gel

An ophthalmic gel, lomefloxacin technology, used in medical preparations containing active ingredients, drug delivery, antibacterial drugs, etc., can solve the loss, tear duct entering the nasal cavity, oral cavity, low ocular bioavailability problem, to achieve the effect of good stability, high drug concentration, and improved bioavailability

Active Publication Date: 2007-08-29
NANJING BAIJINGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The eye drops commonly used clinically at present has obvious shortcoming, and after administration, more than 70% of the medicinal liquid overflows from eye and loses, and then has the loss of 90% if blinking; Very low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Lomefloxacin Hydrochloride 3.3g

[0044] Carbomer 941 6g

[0045] NaOH (10mol / L) about 10ml

[0046] NaCl 6g

[0047] Methylparaben 0.5g

[0048] Distilled water up to 1000g

[0049] The above formula composition can prepare 1000g of ophthalmic gel preparation of the present invention through the following steps, and the preparation method is as follows:

[0050] 1. Stir lomefloxacin hydrochloride with sodium chloride and sodium hydroxide solution until completely dissolved.

[0051] 2. Disperse carbomer into ①, and swell.

[0052] 3. Methylparaben is dissolved in water by heating, and added to the above colloid while stirring, and mixed well.

[0053] 4. Sterilize by heat, cool down, filter, sub-package, pack, and get ready.

Embodiment 2

[0055] Lomefloxacin Hydrochloride 5.3g

[0056] Carbomer 941 6g

[0057] NaOH (10mol / L) about 10ml

[0058] NaCl 6g

[0059] Methylparaben 0.5g

[0060] Distilled water up to 1000g

[0061] The above formula composition can prepare 1000g of ophthalmic gel preparation of the present invention through the following steps, and the preparation method is as follows:

[0062] 1. Stir lomefloxacin hydrochloride with sodium chloride and sodium hydroxide solution until completely dissolved.

[0063] 2. Disperse carbomer into ①, and swell.

[0064] 3. Methylparaben is dissolved in water by heating, and added to the above colloid while stirring, and mixed well.

[0065] 4. Sterilize by heat, cool down, filter, sub-package, pack, and get ready.

Embodiment 3

[0067] Lomefloxacin Hydrochloride 1.6g

[0068] Carbomer 941 6g

[0069] NaOH (10mol / L) about 10ml

[0070] NaCl 6g

[0071] Methylparaben 0.5g

[0072] Distilled water up to 1000g

[0073] The above formula composition can prepare 1000g of ophthalmic gel preparation of the present invention through the following steps, and the preparation method is as follows:

[0074] a) Stir lomefloxacin hydrochloride together with sodium chloride and sodium hydroxide solution until completely dissolved.

[0075] b) Disperse carbomer into ①, and swell.

[0076] c) Methylparaben is dissolved in water by heating, and added to the above colloid with stirring, and mixed evenly.

[0077] d) heating and sterilizing, lowering the temperature, filtering, dispensing and packaging, and the product is obtained.

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Abstract

The present invention relates to a lomefloxacin eye gel preparation. Said preparation is formed from lomefloxacin and pharmaceutically-acceptable carrier suitable for making eye gel. Its formula composition includes carbomer 941, NaOH, NaCl and methylparaben.

Description

Technical field: [0001] The invention relates to an ophthalmic pharmaceutical preparation, in particular to an ophthalmic gel preparation of antibacterial drug lomefloxacin, which is composed of lomefloxacin and a pharmaceutically acceptable carrier suitable for making ophthalmic gel. Background technique: [0002] Lomefloxacin hydrochloride Lomefloxacin (NY-198) is the third-generation quinolone antibacterial agent developed and synthesized by the Central Research Institute of Hokuriku Pharmaceutical Company and Shionogi Company in Japan. Gram-negative bacteria / positive bacteria including Pseudomonas aeruginosa and some anaerobic bacteria showed a broad-spectrum and strong bactericidal effect. It has excellent antibacterial effect on methicillin-resistant Staphylococcus aureus, ampicillin-resistant influenza bacteria, nalidixic acid-resistant Escherichia coli and other drug-resistant bacteria. The antibacterial effect is basically not affected by pH, inoculation amount and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K9/00A61P27/02A61P31/04
Inventor 杨倬英顾颉鲍晓芳
Owner NANJING BAIJINGYU PHARMA
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