Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Water-dispersive nano-grade ibuprofen injecta and preparing method

An injection preparation and dispersibility technology, applied in the field of water dispersible nano-scale ibuprofen injection preparation and preparation thereof, can solve the problems of low drug utilization rate, incomplete flavor correction, poor taste and the like, and achieve a wide application range and good The effect of histocompatibility, excellent stability

Inactive Publication Date: 2007-11-14
ZHEJIANG UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ibuprofen has a strong pungent taste, and the commonly used tablets and granules are not fully corrected, making it poor in mouthfeel; in addition, compared with injection preparations, the utilization rate of orally administered drugs is low

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water-dispersive nano-grade ibuprofen injecta and preparing method
  • Water-dispersive nano-grade ibuprofen injecta and preparing method
  • Water-dispersive nano-grade ibuprofen injecta and preparing method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0027] (1) Dissolve methacrylic acid and water-soluble carbodiimide with a concentration of 0.5g / ml in water at 25°C and pH 7, the weight ratio of methacrylic acid and carbodiimide is 1:2, After stirring for 2 hours, diethylaminoethyl dextran (Ddex) aqueous solution was added dropwise to the above solution. The weight ratio of Ddex to methacrylic acid was 1:0.5. Centrifugal filtration, and dialyzed in triple distilled water for 7 days and then freeze-dried to obtain double bond-containing diethylaminoethyl dextran (MADdex), which 1 The HNMR figure is shown in Figure 1;

[0028] (2) temperature control is 25 ℃, and ibuprofen, Ddex and MADdex are dissolved in the NaOH solution that pH is 12, and the weight volume concentration of ibuprofen is 5mg / ml, the quality of ibuprofen and Ddex and MADdex total amount The ratio is 1:5, and the mass ratio of Ddex to MADdex is 0.2;

[0029] (3) Under the condition of stirring, the HCl solution with a pH of 3 is added dropwise to the soluti...

example 2

[0032] (1) Dissolve acrylic acid and water-soluble carbodiimide with a concentration of 1g / ml in water at 25°C and a pH value of 7. The weight ratio of acrylic acid and carbodiimide is 1:2, and after stirring for 2 hours, Chitosan (CHI) acid solution (pH 3.0) was added dropwise to the above solution, the weight ratio of CHI and acrylic acid was 1:1, after the addition was completed, the temperature was kept constant for 1 day and night, the obtained solution was centrifugally filtered, and placed in three Dialyzed in distilled water for 7 days and then freeze-dried to obtain double bond-containing chitosan (MACHI);

[0033] (2) temperature control is 25 ℃, and ibuprofen, CHI and MACHI are dissolved in the NaOH solution that pH is 12, and the weight volume concentration of ibuprofen is 40mg / ml, the mass of ibuprofen and CHI and MACHI total amount The ratio is 1:10, and the mass ratio of CHI and MACHI is 0.8;

[0034] (3) Under the stirring situation, the HCl solution with pH o...

example 3

[0037](1) Dissolve methacrylic acid and water-soluble carbodiimide with a concentration of 1g / ml in water at 25°C and a pH value of 7. The weight ratio of methacrylic acid and carbodiimide is 1:5, and stir Finally, diethylaminoethyl dextran (Ddex) aqueous solution was added dropwise to the above solution, the weight ratio of Ddex to methacrylic acid was 1:0.5, after the addition was completed, the temperature was kept constant for 1 day and night, and the obtained solution was centrifuged and filtered. And dialyzed in triple distilled water for 7 days and then freeze-dried to obtain double bond-containing diethylaminoethyl dextran (MADdex)

[0038] (2) The temperature is controlled at 25°C, and ibuprofen, Ddex and MADdex are dissolved in NaHCO with a pH of 12 3 In the solution, the weight volume concentration of ibuprofen is 3mg / ml, the mass ratio of ibuprofen and Ddex and MADdex total amount is 1: 5, and the mass ratio of Ddex and MADdex is 0.9;

[0039] (3) Under the condit...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The present invention uses polysaccharide and polysaccharide containing double bond as covering material of medicine, controls the ratio of medicine and polysaccharide and adopts co-condensation-polymerization technique to obtain the water-dispersible brufen injection preparation whose grain-size is 20-1000nm.

Description

technical field [0001] The invention relates to a water-dispersible nano-scale ibuprofen injection preparation and a preparation method thereof, in particular to a water-dispersible nano-scale ibuprofen injection preparation using polysaccharides and double bond-containing polysaccharide biomacromolecular materials as coating materials and its preparation method. Background technique [0002] Ibuprofen is a high-efficiency non-steroidal anti-inflammatory drug, which has strong antipyretic, analgesic and anti-inflammatory effects, and can be used clinically for the treatment of various inflammations and diseases. Ibuprofen currently has 15 specifications and 7 dosage forms in use, including capsules, granules, tablets, suspensions, suppositories, ointments and syrups. The most commonly used method of administration in clinical practice is oral administration. However, ibuprofen has a strong pungent taste, and the commonly used tablets and granules are not fully corrected, w...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61K9/10A61K9/14A61P29/00
Inventor 高长有江兵兵胡玲沈家骢
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com