Water-dispersive nano-grade ibuprofen injecta and preparing method

An injection preparation and dispersibility technology, which is applied in the field of water-dispersible nano-scale ibuprofen injection preparation and its preparation, can solve problems such as poor taste, low drug utilization rate, and incomplete taste correction, and achieve good tissue compatibility , wide application range, excellent stability effect

Inactive Publication Date: 2006-03-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ibuprofen has a strong pungent taste, and the commonly used tablets and granules are not fully corrected, making it poor in mouthfeel; in addition, compared with injection preparations, the utilization rate of orally administered drugs is low

Method used

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  • Water-dispersive nano-grade ibuprofen injecta and preparing method
  • Water-dispersive nano-grade ibuprofen injecta and preparing method
  • Water-dispersive nano-grade ibuprofen injecta and preparing method

Examples

Experimental program
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Effect test

example 1

[0029] (1) Dissolve methacrylic acid and water-soluble carbodiimide with a concentration of 0.5g / ml in water at 25°C and pH 7, the weight ratio of methacrylic acid and carbodiimide is 1:2, After stirring for 2 hours, diethylaminoethyl dextran (Ddex) aqueous solution was added dropwise to the above solution. The weight ratio of Ddex to methacrylic acid was 1:0.5. Centrifugal filtration, and dialyzed in triple distilled water for 7 days and then freeze-dried to obtain double bond-containing diethylaminoethyl dextran (MADdex), which 1 HNMR diagram see figure 1 ;

[0030] (2) temperature control is 25 ℃, and ibuprofen, Ddex and MADdex are dissolved in the NaOH solution that pH is 12, and the weight volume concentration of ibuprofen is 5mg / ml, the quality of ibuprofen and Ddex and MADdex total amount The ratio is 1:5, and the mass ratio of Ddex to MADdex is 0.2;

[0031] (3) Under the condition of stirring, the HCl solution with a pH of 3 is added dropwise to the solution obtain...

example 2

[0034] (1) Dissolve acrylic acid and water-soluble carbodiimide with a concentration of 1g / ml in water at 25°C and a pH value of 7. The weight ratio of acrylic acid and carbodiimide is 1:2, and after stirring for 2 hours, Add chitosan (CHI) acid solution (pH 3.0) dropwise to the above solution, the weight ratio of CHI to acrylic acid is 1:1, keep the temperature for 1 day and night after the addition, the obtained solution is centrifuged and filtered, and placed in three evaporators. Dialyzed in water for 7 days and then freeze-dried to obtain double bond-containing chitosan (MACHI);

[0035] (2) temperature control is 25 ℃, and ibuprofen, CHI and MACHI are dissolved in the NaOH solution that pH is 12, and the weight volume concentration of ibuprofen is 40mg / ml, the mass of ibuprofen and CHI and MACHI total amount The ratio is 1:10, and the mass ratio of CHI and MACHI is 0.8;

[0036] (3) Under the stirring situation, the HCl solution with pH of 3 is added dropwise in the sol...

example 3

[0039] (1) Dissolve methacrylic acid and water-soluble carbodiimide with a concentration of 1g / ml in water at 25°C and a pH value of 7. The weight ratio of methacrylic acid and carbodiimide is 1:5, and stir Finally, diethylaminoethyl dextran (Ddex) aqueous solution was added dropwise to the above solution, the weight ratio of Ddex to methacrylic acid was 1:0.5, after the addition was completed, the temperature was kept constant for 1 day and night, and the obtained solution was centrifuged and filtered. And dialyzed in triple distilled water for 7 days and then freeze-dried to obtain double bond-containing diethylaminoethyl dextran (MADdex)

[0040] (2) The temperature is controlled at 25°C, and ibuprofen, Ddex and MADdex are dissolved in NaHCO with a pH of 12 3 In the solution, the weight volume concentration of ibuprofen is 3mg / ml, the mass ratio of ibuprofen and Ddex and MADdex total amount is 1: 5, and the mass ratio of Ddex and MADdex is 0.9;

[0041] (3) Under the condi...

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Abstract

The present invention uses polysaccharide and polysaccharide containing double bond as covering material of medicine, controls the ratio of medicine and polysaccharide and adopts co-condensation-polymerization technique to obtain the water-dispersible brufen injection preparation whose grain-size is 20-1000nm.

Description

technical field [0001] The invention relates to a water-dispersible nano-scale ibuprofen injection preparation and a preparation method thereof, in particular to a water-dispersible nano-scale ibuprofen injection preparation using polysaccharides and double bond-containing polysaccharide biomacromolecular materials as coating materials and its preparation method. Background technique [0002] Ibuprofen is a high-efficiency non-steroidal anti-inflammatory drug, which has strong antipyretic, analgesic and anti-inflammatory effects, and can be used clinically for the treatment of various inflammations and diseases. Ibuprofen currently has 15 specifications and 7 dosage forms in use, including capsules, granules, tablets, suspensions, suppositories, ointments and syrups. The most commonly used method of administration in clinical practice is oral administration. However, ibuprofen has a strong pungent taste, and the commonly used tablets and granules are not fully corrected, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/10A61K9/14A61P29/00
Inventor 高长有江兵兵胡玲沈家骢
Owner ZHEJIANG UNIV
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