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Method for preparing hole structure gradient changing spherical inner hole artificial bone

A gradient change, artificial bone technology, applied in the direction of bone implants, etc., can solve the problems of poor channel connectivity and insufficient scaffold strength, and achieve the effects of good connectivity, good mechanical properties and biocompatibility

Inactive Publication Date: 2008-05-28
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the shortcomings of insufficient support strength and poor channel connectivity in the prior art, the purpose of the present invention is to provide a method for preparing a spherical inner hole artificial bone with a gradient change in the pore structure. The bioceramic support prepared by this method has Three-dimensional connected spherical inner pores, the porosity and pore size change according to the gradient, with the characteristics of high strength and good connectivity

Method used

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  • Method for preparing hole structure gradient changing spherical inner hole artificial bone
  • Method for preparing hole structure gradient changing spherical inner hole artificial bone
  • Method for preparing hole structure gradient changing spherical inner hole artificial bone

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preparation example Construction

[0036] The preparation method of the artificial bone with the spherical inner hole in which the pore structure is gradiently changed comprises the following steps:

[0037] The first step, preparation of binder and slurry

[0038] Dissolve 0.5-1.0g of PS plastic into 10-100ml of carbon tetrachloride, stir to dissolve completely, and let stand until clarified to obtain a binder;

[0039] Add 10-200ml of absolute ethanol to 10-50g of hydroxyapatite powder with a particle size of 0.1-5μm, and then add 0.2-3ml of polyvinyl butyral. The volume ratio of the powder and the mixture of absolute ethanol is 1%, and the mixture is evenly stirred to obtain a hydroxyapatite slurry;

[0040] The second step, the preparation of polymer spheroid scaffold

[0041] Take polyvinyl chloride spheres and salt crystals and mix them in a volume ratio of 2:1 to 5:1. The particle diameters of the polyvinyl chloride spheres and salt crystals are 50 to 1000 μm and 20 to 600 μm respectively, and the part...

Embodiment 1

[0049] The preparation method of the artificial bone with the spherical inner hole in which the pore structure is gradiently changed comprises the following steps:

[0050] The first step, preparation of binder and slurry

[0051] Dissolve 0.5g of PS plastic into 30ml of carbon tetrachloride, stir to dissolve completely, and let stand until clarification to obtain a binder;

[0052] Add 10ml of absolute ethanol to 20g of hydroxyapatite powder with a particle size of 0.1-5μm, and then add 0.2ml of polyvinyl butyral. The volume ratio of the mixture is 1%, and the mixture is evenly stirred to obtain a hydroxyapatite slurry;

[0053] The second step, the preparation of polymer spheroid scaffold

[0054] Take polyvinyl chloride spheres with a particle size of 50-380 μm and salt crystals with a particle size of 20-230 μm, mix them in a volume ratio of 2:1, and place them in a plastic mold. The polyvinyl chloride spheres and salt crystals are placed in the mold The arrangement is ...

Embodiment 2

[0060] The preparation method of the artificial bone with the spherical inner hole in which the pore structure is gradiently changed comprises the following steps:

[0061] The first step, preparation of binder and slurry

[0062] Dissolve 0.6g of PS plastic into 40ml of carbon tetrachloride, stir to dissolve completely, and let it stand until clarified to obtain a binder;

[0063] Add 200ml of absolute ethanol to 30g of hydroxyapatite powder with a particle size of 0.1-5μm, and then add 3ml of polyvinyl butyral, which will occupy the mixture of hydroxyapatite powder and absolute ethanol The volume ratio of the mixture is 1%, and the mixture is evenly stirred to obtain a hydroxyapatite slurry;

[0064] The second step, the preparation of polymer spheroid scaffold

[0065] Take polyvinyl chloride spheres with a particle size of 150-550 μm and salt crystals with a particle size of 60-325 μm, mix them in a volume ratio of 3:1, and place them in a plastic mold. The polyvinyl chl...

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Abstract

The preparation process of artificial bone with spherical inner hole in gradient changing structure includes the following steps: mixing PVC balls and table salt crystal in certain ratio, setting the mixture inside mold, injecting adhesive, washing out salt with deionized water after the adhesive is cured to obtain PVC polymer template, injecting hydroxy apatite slurry, heating to dry and sintering. The hydroxy apatite rack with 3D communicated spherical structure has high strength, good pore communication, gradiently changing porosity and pore size, structure similar to natural bone, raised mechanical performance and biocompatibility, and important significance on the clinical research in bone tissue engineering.

Description

technical field [0001] The invention relates to a method for preparing an artificial bone, in particular to a method for preparing an artificial bone with a spherical inner hole whose pore structure changes gradually. Background technique [0002] In the field of bone tissue engineering, the porous scaffold as a repair or implant material provides a suitable environment for cell growth, which is of great significance to the clinical research of bone tissue engineering. In the prior art, there are many studies on the shape, material selection and preparation methods of porous scaffolds. [0003] (1) Chinese Patent [Application No.] 03141972, Publication Date: 2004.4.7 Publication No.: 1486754 "A Spherical Polymer Porous Scaffold and Preparation Method for Compression Molding" discloses the use of polymers to prepare scaffolds, and this method is limited to the preparation of high For molecular biomaterials, the compression molding method is used in the preparation process to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28C08J9/00
Inventor 赵康陈永楠
Owner XIAN UNIV OF TECH