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Gonadoliberin double-way genital regulating medicine and reproduction of fowl

A gonadotropin and pathway technology, used in drug combinations, pharmaceutical formulations, sexual diseases, etc., can solve problems such as unguaranteed drug efficacy, poor drug sensitivity in rare animals, and aggravated stress response, so as to reduce accessory-induced infertility, The effect of reducing parental ovulation death and reducing stress response

Inactive Publication Date: 2009-06-03
宋艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In early spring and autumn, the temperature and water temperature are unstable, making it difficult to determine the dosage of GnRH analogues, and the efficacy of the medicine cannot be guaranteed; coupled with environmental changes, the stress response after using the medicine is intensified, often resulting in low artificial reproduction efficiency
[0008] ③ Rare animals are poorly sensitive to existing drugs
[0009] GnRH analogs are species-specific, animals are less sensitive to commercially available GnRH analogs and their combinations, and the process of reproductive regulation cannot be completed, making artificial reproduction difficult to achieve
[0010] ④ Embryo transfer drug effect is difficult to control
The use of FSH is not only expensive, but also prone to drug resistance, resulting in sluggish female reproductive system
[0012] ⑤Poor drug regulation, affecting large-scale reproduction
However, since SERMs only act on the lower end of the gonadal axis, they are ineffective on regulation other than estrogen receptors

Method used

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  • Gonadoliberin double-way genital regulating medicine and reproduction of fowl
  • Gonadoliberin double-way genital regulating medicine and reproduction of fowl
  • Gonadoliberin double-way genital regulating medicine and reproduction of fowl

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] This example 1 is a gonadotropin-releasing hormone dual-path reproductive regulation drug for artificial reproduction of grass carp whose eggs have developed to stage IV. According to each kg female fish consists of the following raw materials:

[0045] Gonadotropin-releasing hormone 2 μg

[0046] Domperidone 2mg

[0047] Isoflavones and their analogs 1mg.

[0048] The artificial propagation method of using the above-mentioned medicines in fish is to dissolve gonadotropin-releasing hormone in water at normal temperature, then dissolve domperidone, isoflavones and similar substances in water and mix them, and inject them intramuscularly. The dosage is per kilogram The amount of each component added to the female fish during the ovulation period is: 1.5 μg of gonadotropin-releasing hormone, 1 mg and 0.5 mg of domperidone, isoflavones and the like; : Gonadotropin-releasing hormone 0.5μg, domperidone, isoflavones and similars 1mg, 0.5mg respectively, control the temperat...

Embodiment 2

[0050] Example 2 is a gonadotropin-releasing hormone dual-path reproductive regulation drug for artificial reproduction of white papaya. According to each kg female fish consists of the following components:

[0051] Gonadotropin-releasing hormone analog (GnRH-A) 12.5μg

[0052] Reserpine 4mg

[0053] Raloxifene 2mg.

[0054] The artificial reproduction method of using the above-mentioned medicines for fish is to dissolve gonadotropin-releasing hormone in water at normal temperature, then dissolve reserpine and raloxifene in water and mix them, and inject intramuscularly. The amount of each component added in the ovulation period per kilogram of female fish is: 10 μg of gonadotropin-releasing hormone analogues, 3 mg and 0.5 mg of reserpine and raloxifene respectively; The amount added is: 2.5 μg of gonadotropin-releasing hormone analogues, 1 mg of reserpine and raloxifene respectively, the temperature of water for ripening and production is controlled at 24°C to 32°C, and t...

Embodiment 3

[0056] This example 3 is a gonadotropin-releasing hormone dual-path reproductive regulation drug used for the artificial reproduction of the three-flowered scale fish with 28 days as a reproductive cycle in one year. According to each kg female fish consists of the following components:

[0057] GnRH 25μg

[0058] Haloperidone 220mg

[0059] Tamoxifen 220mg.

[0060] The artificial reproduction method of using the above-mentioned drugs in fish is to dissolve gonadotropin-releasing hormone in water at room temperature, then dissolve haloperidol and tamoxifen in water and mix them, and inject them intramuscularly. The dosage is 1 kg of female fish The amount of each component added in the ovulation period is: 20 μg of gonadotropin-releasing hormone, 200 mg of haloperidol and tamoxifen respectively; Haloperidone and tamoxifen are 20 mg respectively, the water temperature for ripening is controlled at 14°C to 32°C, and the amount used for each kilogram of male fish is 1 / 5 to 1 / ...

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Abstract

A medicine for dual-approach regulation to the reproduction of fish and domestic animals and fowls is prepared from gonadotropin-releasing hormone or its analog, dopamine antagon and selective estrogen receptor regulator. Its application method is also disclosed.

Description

Technical field: [0001] The invention is related to reproductive regulation medicine, especially related to gonadotropin-releasing hormone dual pathway reproductive regulation medicine and poultry artificial breeding method. Background technique: [0002] The positive effect of GnRH (gonadotropin-releasing hormone) is to promote (+) animal fertility (sperm, egg maturation, ovulation, ovulation), and negative feedback inhibits (-) reproduction. [0003] Animal husbandry and aquaculture have widely used GnRH analogues in embryo transfer, artificial insemination, and artificial induced labor. The purpose is to promote animal reproduction, but there are the following problems in production practice: [0004] ①Fish dystocia and death [0005] In fish artificial breeding, it is difficult for farmers to grasp the dose threshold of GnRH analogues. If the dose is insufficient, there will be no ovulation effect; if the dose exceeds the threshold, negative feedback will occur, result...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/22A61K45/06A61P15/00A61P15/08
Inventor 宋艳
Owner 宋艳
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