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Application of isosteviol in pharmacy

A technology of isosteviol and its application, which is applied in the application field of isosteviol in pharmaceuticals, and can solve the problems of no isosteviol influence on atherosclerosis, no isosteviol influence on blood lipids, etc.

Inactive Publication Date: 2007-08-01
JINLING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] There is no report on the effect of isosteviol on blood lipids in the current literature, and there is no report on the effect of isosteviol on atherosclerosis

Method used

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  • Application of isosteviol in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Effects of Isosteviol on Blood Lipid Levels of High-Fat Food Rats

[0032] 1. Experimental method

[0033] 1. Animals: SD male rats, 150-200 g, 8 weeks old, provided by Nanjing Jiangning Qinglongshan Animal Breeding Farm, animal certificate number: Su Dongzhi SCXK2002-0017. Animal feed and bedding are also provided by the company.

[0034] 2. Preparation of high-fat model [10-14] : SD rats were normally given high-fat feed and water, and high-fat model rats were fed with high-fat liquid (high-fat emulsion) once a day.

[0035] 2.1 Composition of high-fat liquid:

[0036] Lard (commercially available), cholesterol (China Huixing Biochemical Reagent Co., Ltd. Shanghai, batch number 20031125),

[0037] Propylthiouracil (Guangdong South China Pharmaceutical Co., Ltd., batch number 051101),

[0038] Pig bile salt (Sinopharm Chemical Reagent Co., Ltd., batch number F20050916),

[0039] Glycerin (Sinopharm Chemical Reagent Co., Ltd.).

[0040] 400g of lard, 5...

Embodiment 2

[0058] Example 2: Regulating blood lipid and anti-atherosclerosis effect of rabbit isosteviol

[0059] 1. Experimental method

[0060] 1. Experimental animals 40 healthy New Zealand rabbits, half male and half male, weighing 2.0-2.4 kg, provided by the Medical Experimental Animal Center of Southeast University, with a certificate of conformity (SYXK (Su) 2002-0012). Normal control rabbits were fed with ordinary standard feed, and high-fat model rabbits were fed with high-fat feed. Room temperature (18-22°C), free access to food and water.

[0061] 2. Preparation of high-fat model

[0062] Rabbits were first adapted to feeding in the laboratory for three days. Add 1.5% of cholesterol and 3% of lard to the common standard feed, mix evenly, and process into a high-fat feed, which is processed once a week. Store in dark and cool place. In addition to the normal diet group, the animals in the high-fat model group were fed with high-fat diet for 12 weeks to form a high-fat mode...

Embodiment 3

[0082] Take 1.0 g of isosteviol, add appropriate amount of dextrin, sodium carboxymethylcellulose, and crospovidone, mix well, and dry to prepare 1000 isosteviol capsules, each containing 1 mg of isosteviol.

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Abstract

The invention disclosed the application of isosteviol in medicine preparing process. The application refers to its application in preparing drugs for regulating blood fat and in preparing anti-atherogenic agent. The application shows that isosteviol can be used as new lipid regulating agent and antiatherogenic agent which is of positive significance for preventing coronary atherosclerotic heart disease and stroke.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to the application of isosteviol in pharmacy. Background technique [0002] Isosteviol (Isosteviol) chemical name ent-16-oxobeyeran-19-oic acid is the acid hydrolysis product of stevioside (stevioside), which belongs to diterpenoids, and its structural formula is as follows: [0003] [0004] In the prior art, a large amount of research has been done on the pharmacological action of isosteviol, which is mainly manifested in the following aspects: [0005] 1. Anti-myocardial ischemia protective effect: isolated guinea pig heart perfusion, ischemia for 30 minutes and reperfusion for 90 minutes can cause the reduction of systolic and diastolic functions in the guinea pig heart. Pretreatment with isosteviol (1-10 μmol / L) before ischemia-reperfusion can dose-dependently improve the injury caused by ischemia-reperfusion; reduce the increase of MDA level and SOD level caused by myocardial ischemia...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61P3/06A61P9/10
Inventor 许德义孙晔徐向阳田丽娟徐民谢俊陈伟奇张惠张庆晓万辉
Owner JINLING PHARMA
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