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Extraction method of water soluble components from salvia miltiorrhiza by ultrasonic continuous countercurrent gradient

An ultrasound-enhanced, water-soluble technology, applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, pharmaceutical formulas, etc., can solve the problems that restrict the extraction efficiency of active ingredients and achieve the goal of improving extraction efficiency Effect

Inactive Publication Date: 2007-08-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In ultrasonic static one-time extraction, the concentration difference between the active ingredients in the raw material and the solvent is the largest at the initial stage of extraction, and the concentration difference is the smallest when it is close to equilibrium, thus restricting the extraction efficiency of active ingredients

Method used

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  • Extraction method of water soluble components from salvia miltiorrhiza by ultrasonic continuous countercurrent gradient

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Using four-stage ultrasonic-enhanced dynamic circulation continuous countercurrent extraction, gradient creation and circulation extraction tests were carried out in an ultrasonic cleaner. The salvia miltiorrhiza medicinal material is crushed and passed through a 100-mesh standard inspection sieve, and 20 g of the salvia miltiorrhiza powder is weighed with an electronic balance. The extractant is water, the extraction time is 20min, the extraction temperature is 80°C, the solid-liquid ratio is 8ml / g, the ultrasonic frequency is 40kHz, and the ultrasonic power is 600W. In order to fully extract, an electric stirrer is used to stir.

[0021] The gradient method is as follows: Ultrasonic extraction is performed on three tanks with the same amount of medicinal materials and the same ratio of solid to liquid, and the method of dynamically manufacturing gradients is adopted. As shown in the virtual frame of the schematic diagram, the same medicinal materials are placed in the ...

Embodiment 2

[0026] Using four-stage ultrasonic-enhanced dynamic circulation continuous countercurrent extraction, gradient creation and circulation extraction tests were carried out in an ultrasonic cleaner. The salvia miltiorrhiza medicinal material is pulverized and passed through a 100-mesh standard inspection sieve, and more than 20 g of the same amount of salvia miltiorrhiza powder is weighed with an electronic balance. The extractant is water, the extraction time is 5min, the extraction temperature is 100°C, the solid-liquid ratio is 4ml / g, the ultrasonic frequency is 40kHz, and the ultrasonic power is 400W. In order to fully extract, an electric stirrer is used to stir.

[0027] The gradient method is as follows: Ultrasonic extraction is performed on three tanks with the same amount of medicinal materials and the same ratio of solid to liquid, and the method of dynamically manufacturing gradients is adopted. As shown in the virtual frame of the schematic diagram, the same medicinal ma...

Embodiment 3

[0032] Using four-stage ultrasonic-enhanced dynamic circulation continuous countercurrent extraction, gradient creation and circulation extraction tests were carried out in an ultrasonic cleaner. The salvia miltiorrhiza medicinal material is pulverized and passed through a 100-mesh standard inspection sieve, and more than 20 g of the same amount of salvia miltiorrhiza powder is weighed with an electronic balance. The extractant is water, the extraction time is 30min, the extraction temperature is 40°C, the solid-liquid ratio is 12ml / g, the ultrasonic frequency is 40kHz, and the ultrasonic power is 320W. In order to fully extract, an electric stirrer is used to stir.

[0033] The gradient method is as follows: Ultrasonic extraction is performed on three tanks with the same amount of medicinal materials and the same ratio of solid to liquid, and the method of dynamically manufacturing gradients is adopted. As shown in the virtual frame of the schematic diagram, the same medicinal...

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Abstract

The invention disclosed a way to extract water soluble ingredient in danshen root with gradient hyper sound fortified successive countercurrent. After putting the jar with danshen root and solvents in hyper sound (the frequency is 40kHz and the power is 320-600W) for t, transferring the solvent to another jar with danshen root; putting new solvent into the first jar; extracting the two jars of danshen root at the same time and transferring the solvent one by one; successively countercurrent extracting the active ingredient in danshen root. Compared with the traditional hyper sound extracting method, the countercurrent extracting method in the invention can keep the density differences between the solid and liquid phase in a high level and decrease the solvents dosage so as to save the energy to condense, increase the extracting efficiency and increase the yield.

Description

technical field [0001] The invention relates to a method for extracting effective components of traditional Chinese medicine, in particular to a method for continuously countercurrently extracting water-soluble components in the traditional Chinese medicine Salvia miltiorrhiza in an ultrasonic-enhanced dynamic circulation stage. Background technique [0002] Salvia Miltiorrhiza Bunge is the dried root and rhizome of the labiatae plant (Salvia Miltiorrhiza Bunge), which has the effects of dispelling blood stasis and relieving pain, promoting blood circulation and stimulating menstruation, clearing heart and eliminating troubles. Pharmacological studies of traditional Chinese medicine have shown that Salvia miltiorrhiza can increase coronary blood flow, lower blood lipids, inhibit thrombosis or antithrombosis, and improve microcirculation. Danshen mainly contains fat-soluble and water-soluble components. The fat-soluble components are mainly diterpenoids, and the water-solubl...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P3/06A61P7/02A61P9/10A61K125/00
Inventor 吴跃焕陈赟
Owner SOUTH CHINA UNIV OF TECH
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