Antiprotozoal agent

A technology of antigen and solvate, which is applied in anti-infective drugs, plant raw materials, and resistance to vector-borne diseases, etc.

Inactive Publication Date: 2007-10-03
HEALTH SCI TECH TRANSFER CENT JAPAN HEALTH SCI FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far there is no report about the treatment of tropical infectious skin diseases with Ziyun Ointment

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0066] The hexane extract of comfrey (obtained by the method of Reference Example 1), the hexane extract of the comfrey and angelica mixture (obtained by the method of Reference Example 2), shikonin (NagaraScience), and acetyl shikonin (obtained by the method of Reference Example 2) were measured. Nagara Science), β, β-dimethylacryloyl shikonin (Nagara Science), isobutyryl shikonin (Nagara Science), α-methyl n-butyryl shikonin (Nagara Science), isovaleryl Shikonin (Nagara Science), β-hydroxyisovaleryl shikonin (Nagara Science) and Shikonin (Wako Pure Chemical Industries, Ltd.) have anti-Leishmania activities.

[0067] First, 1 to 5 mg of each sample is dissolved in dimethyl sulfoxide (DMSO) to prepare a DMSO solution (10 mg / ml). Then, the solution (800 μg / ml) was diluted with Medium 199 medium and passed through the filter membrane. The sample solution was adjusted to 9 concentrations, and 50 μl of the sample solution of each concentration and 50 μl of the Leishmania culture solut...

reference example 1

[0071] Preparation of Hexane Extract of Lithospermum erythrorhizon

[0072] The dried comfrey pulverized by a grinder was put into an eggplant-shaped flask, 30 times the amount of hexane was added, and the mixture was extracted at 45°C for 5 hours. After that, filtration was performed to concentrate the filtrate to dryness to obtain an extract.

reference example 2

[0074] Preparation of Hexane Extract of Lithospermum and Angelica Mixture

[0075] Weigh the same amount of dried comfrey and dried angelica pulverized by a grinder, put them in an eggplant-shaped flask, add 30 times the amount of hexane of the mixture of comfrey and angelica, and extract at 45°C for 5 hours. After that, filtration was performed to concentrate the filtrate to dryness to obtain an extract.

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Abstract

An antiprotozoal agent effective especially as an antileishmania agent. The antiprotozoal agent contains as an active ingredient a compound represented by the formula (I): [Chemical formula 1] (I) (wherein R represents -H or acyl), a salt of the compound, or a solvate of either.

Description

Technical field [0001] The invention relates to an antiprotozoal agent. Background technique [0002] For the use of chemotherapy to treat infectious diseases caused by protozoa, the most serious problem is that the protozoa will develop drug resistance. For example, a typical example is the resistance of falciparum malaria. So far, although some therapeutic drugs have been developed, protozoa that have developed resistance to these drugs have also appeared. Therefore, protozoan infectious diseases are spreading worldwide. One of the protozoan infectious diseases is leishmaniasis. [0003] Leishmaniasis is a parasitic disease that is caused by Leishmania and is unique to tropical regions including South America. This disease is one of the six tropical diseases designated by the World Health Organization (WHO). There are approximately 12 million patients in Africa, the Middle East, Central and South America, and Asia. In addition, 400,000 people are infected with this disease ever...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K31/222A61K36/30A61P33/02A61K36/00A61K36/18A61K36/185A61K36/23A61K36/232A61P43/00
CPCA61K36/30A61K31/122A61K36/232A61P33/02A61P43/00Y02A50/30A61K2300/00
Inventor 渕野裕之关田节子高桥真理衣佐竹元吉
Owner HEALTH SCI TECH TRANSFER CENT JAPAN HEALTH SCI FOUND
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