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Gynaecologic menstruation regulating preparation for treating gynecopathy and its preparation method and quality control method

A technology for gynecological diseases and gynecological menstruation regulation, which is used in sexual diseases, testing pharmaceutical preparations, medical preparations containing active ingredients, etc.

Active Publication Date: 2007-10-24
GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to: provide a gynecological menstruation regulating preparation for treating gynecological diseases and its preparation method; the present invention provides micropills and dispersible tablets with good disintegration and high bioavailability, especially suitable for the elderly People and patients who have difficulty swallowing tablets or capsules can take it; the soft capsule preparation provided by the invention is formed by sealing the medicine in a soft rubber shell, which solves the problem of the medicine being unstable when exposed to heat and humidity, and can also cover up the bad taste and smell of the medicine , can play the role of increasing stability and improving bioavailability; the dropping pills provided by the invention have good mouthfeel, fast absorption, high bioavailability, and are convenient to take

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0196] Example 1 of the present invention: Angelica sinensis 32g, Chuanxiong 3.6g, vinegar roasted Xiangfu 88.9g, bran-fried Baizhu 5.1g, white peony root 2.6g, red peony 2.6g, vinegar roasted Corydalis 7.1g, Rehmannia glutinosa 10.7g, jujube 17.8g, licorice 2.4g

[0197] Take angelica, chuanxiong, vinegar roasted xiangfu, bran stir-fried atractylodes, white peony root, red peony, vinegar roasted Corydalis, rehmannia glutinosa, jujube, licorice, add water and decoct twice, the first time is 3 hours, the second time is 2 hours, Filter, combine the filtrate, concentrate under reduced pressure to a clear ointment with a relative density of 1.18-1.20 when the relative density is 80~85℃, dry under reduced pressure, and pulverize; add polyethylene glycol at the ratio of 1 part of powder and 2 parts of polyethylene glycol 4000 4000, mix evenly, heat and melt, stir evenly, transfer to the dropping pill machine, drop distance 5cm, drop speed 35d / min, material temperature 75℃, drop into dim...

Embodiment 2

[0198] Example 2 of the present invention: Angelica sinensis 32g, Chuanxiong 3.6g, vinegar roasted Xiangfu 88.9g, bran-fried Baizhu 5.1g, white peony root 2.6g, red peony 2.6g, vinegar roasted Corydalis 7.1g, Rehmannia glutinosa 10.7g, jujube 17.8g, licorice 2.4g

[0199] Take angelica, chuanxiong, vinegar roasted xiangfu, bran stir-fried atractylodes, white peony root, red peony, vinegar roasted Corydalis, rehmannia glutinosa, jujube, licorice, add water and decoct twice, the first time is 3 hours, the second time is 2 hours, Filter, combine the filtrate, concentrate under reduced pressure to a clear paste with a relative density of 1.18-1.20 when the relative density is 80~85℃, dry under reduced pressure, pulverize, add appropriate amount of starch, make soft material with 70% ethanol and soybean oil, and squeeze— Pellets are made by spheronization or a coating pan is used for making pellets, and dried to obtain pellets.

Embodiment 3

[0200] Example 3 of the present invention: Angelica sinensis 32g, Chuanxiong 3.6g, vinegar roasted Xiangfu 88.9g, bran-fried Baizhu 5.1g, white peony root 2.6g, red peony root 2.6g, vinegar roasted Corydalis 7.1g, Rehmannia glutinosa 10.7g, jujube 17.8g, licorice 2.4g

[0201] Take angelica, chuanxiong, vinegar roasted xiangfu, bran stir-fried atractylodes, white peony root, red peony, vinegar roasted Corydalis, rehmannia glutinosa, jujube, licorice, add water and decoct twice, the first time is 3 hours, the second time is 2 hours, Filter, combine the filtrate, concentrate under reduced pressure to a clear cream with a relative density of 80-85°C, which is 1.18-1.20, dry under reduced pressure, and pulverize; take CMC-Na: PVPP: mannitol = 1:2:2 and mix with appropriate amount of pigment. As a preparation excipient, take 3 / 5 of the preparation excipient and mix it with about 8 times the amount of CMC-Na powder, and use 2% PVP-K 30 Anhydrous ethanol liquid is used as a binder, 40 me...

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PUM

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Abstract

The invention relates to a pharmaceutical preparation for treating gynaecologic diseases and regulating menstruation, its preparing process and quality control method, wherein the preparation is made mainly from Chinese angelica root, Ligusticum wallichii, prepared nutgrass flatsedge rhizome, white atractylodes rhizome, root of herbaceous peony and red peony root, and can be made into dispersible tablets, mini-pills, dripping pills, soft capsules and pharmacologically allowable dose forms. The invention also provides the method for determining and identifying contents of the preparation.

Description

Technical field [0001] The invention is a gynecological menstruation regulating preparation for treating gynecological diseases, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicine. technical background [0002] Gynecological diseases such as irregular menstruation and abdominal pain during menstruation are common diseases threatening women’s physical and mental health in the world today, causing great suffering to women. In order to achieve the purpose of prevention and treatment, many inventors and pharmaceutical companies have done a lot of research , It also provides some therapeutic products; such as Gynecological Menstrual Regulating Granules, but the granules are large in dosage, and the amount of auxiliary materials is large, which is easy to absorb moisture and the product quality is unstable. Moreover, the variety of dosage forms is not abundant enough, and the scope of application is narrow. The ...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61K36/899A61K9/06A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61K9/70A61P15/00G01N30/90G01N30/02G01N33/15
Inventor 于文风
Owner GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
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