Function of pseudolarix acetic acid as medicine for inducing tumor cells to die

A technology of tumor cell apoptosis and hibiscus acetic acid, applied in the field of compounds, can solve the problems of unclear mechanism of action of active ingredients, restricting the development and compatibility of anti-cancer drugs, etc., and achieves the effects of fast onset, inhibition of production and small dose.

Inactive Publication Date: 2007-10-31
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although hibiscus bark has been used to treat tumors and has a certain effect, the mechanism of action of its active ingredients is still unclear, which limits its development as an anticancer drug and its compatibility with other drugs

Method used

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  • Function of pseudolarix acetic acid as medicine for inducing tumor cells to die
  • Function of pseudolarix acetic acid as medicine for inducing tumor cells to die
  • Function of pseudolarix acetic acid as medicine for inducing tumor cells to die

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Embodiment 1

[0024] The present invention adopts two kinds of cell lines for cell culture, and through the morphological observation method, nuclear fluorescence staining observation and DNA fragmentation analysis experiment, it is confirmed that hibiscus bark acetic acid induces the death mechanism of HeLa cells and A375-S2 cells to induce cell apoptosis. Hibiscus bark acetic acid can be used as the lead compound of anticancer drugs, and can also be directly developed into new anticancer drugs or combined with other drugs to form new anticancer drugs.

[0025] Hibiscus bark acetic acid as an anticancer drug has the characteristics of small dose, quick onset and obvious effect.

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Abstract

The invention discloses an application with hibiscus peel acetic acid to evoke tumor cell to die, which is characterized by the following: extracting effective element of hibiscus peel acetic acid from hibiscus peel; using hibiscus peel acetic acid to antimycotics haemostasis, nerve dermitis and so on aspects; unknowing making mechanism of hibiscus peel; restricting development of hibiscus peel . This invention can resolve the above problems.

Description

Technical field: [0001] The invention relates to a new application of a compound, in particular to the application of hibiscus bark acetic acid as a drug for inducing tumor cell apoptosis. Background technique: [0002] The traditional Chinese medicine Hibiscus bark is the dry root bark or the near-root bark of the Pinaceae plant Pseudolarix Kaempferi Gordon. Seen in "Compendium of Materia Medica Supplements" written by Zhao Xuemin in the Qing Dynasty, it is warm in nature, pungent in taste, and poisonous. Return lung, spleen channel. It has the effect of killing insects and relieving itching. Traditional Chinese medicine is clinically used for killing insects and relieving itching, tinea manus, pedis, neurodermatitis, cancer, etc. [0003] Hibiscus bark acetic acid is an active ingredient extracted from hibiscus bark, and its chemical structure is diterpene acid. In previous applications and researches, hibiscus bark acetic acid was mainly used for anti-true hemostasis ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/215A61K36/15A61P35/00
Inventor 龚显峰安巍巍李强赵学玲王阳吴振
Owner HEILONGJIANG UNIV
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