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Method for enriching and purifying veralkcohol from peanut root by macporous adsorptive resin

A technology of resveratrol and peanut root, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry and other directions, can solve the problems of low extraction purity and low extraction rate, and achieve high extraction purity, large adsorption capacity, The effect of stable physical and chemical properties

Inactive Publication Date: 2007-11-21
河南省农科院农副产品加工研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the disadvantages of relatively low extraction rate and low extraction purity of conventional techniques, and provide a method for enriching and purifying resveratrol in peanut roots using macroporous adsorption resins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: A kind of method utilizing macroporous adsorption resin to enrich and purify resveratrol in peanut root, its steps are as follows:

[0027] (1) After crushing the dried peanut root, pass through a 60-mesh sieve, soak and extract with ethyl acetate whose volume is 10 times that of the peanut root powder for 48 hours;

[0028] (2) suction-filtering the peanut root extract treated in step (1) to obtain the extract and reclaiming the solvent under reduced pressure to obtain the primary extract;

[0029] (3) Heating and dissolving the obtained initial extract with water, adding ethyl acetate whose volume is 20 times the volume of the extract aqueous solution to extract, then adjusting its pH value to 9.0 with aqueous sodium hydroxide solution, standing, suction filtration, and decompression Recover the solvent to obtain the crude extract of resveratrol;

[0030] (4) The obtained resveratrol crude extract is adsorbed on a macroporous adsorption resin chromatogr...

Embodiment 2

[0035] Embodiment 2: A kind of method utilizing macroporous adsorption resin to enrich and purify resveratrol in peanut root, its steps are as follows:

[0036] (1) Pass through a 10-mesh sieve after the dried peanut root is pulverized, soak for 12 hours with acetone 20 times the volume of peanut root powder, and then reflux and extract for 4 hours;

[0037] (2) suction-filtering the peanut root extract treated in step (1) to obtain the extract and reclaiming the solvent under reduced pressure to obtain the primary extract;

[0038] (3) Heating and dissolving the obtained primary extract with water, adding ethyl acetate whose volume is 10 times the volume of the extract aqueous solution for extraction, then adjusting its pH value to 7.0 with ammonia water, standing, suction filtration, and concentrating under reduced pressure to obtain white quinoa Retrol crude extract;

[0039] (4) The obtained resveratrol crude extract is adsorbed with a macroporous adsorption resin, and th...

Embodiment 3

[0044] Embodiment 3: A kind of method utilizing macroporous adsorption resin to enrich and purify resveratrol in peanut root, its steps are as follows:

[0045] (1) Pass through an 80-mesh sieve after the dried peanut root is pulverized, and reflux extraction with 75% ethanol with 15 times the volume of peanut root powder for 6 hours;

[0046] (2) suction-filtering the peanut root extract treated in step (1) to obtain the extract and reclaiming the solvent under reduced pressure to obtain the primary extract;

[0047] (3) Heating and dissolving the obtained initial extract with water, adding ethyl acetate whose volume is 10 times the volume of the extract aqueous solution for extraction, then adjusting its pH value to 11.0 with aqueous sodium hydroxide solution, standing, suction filtration, and decompression Recover the solvent to obtain the crude extract of resveratrol;

[0048] (4) The obtained resveratrol crude extract is adsorbed on a macroporous adsorption resin chromat...

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Abstract

A method for enriching and purifying resveratrol from peanut root by macro-porous adsorptive resin is carried out by crushing dried peanut root, extracting by organic solvent, extraction filtering for extract, recovering solvent to obtain first extract, heating by water, dissolving, adding into acetic ether, extracting, regulating pH value to 7.0-11.0, laying aside, extraction filtering, decompressing, concentrating to obtain resveratrol coarse extract, adsorbing by macro-porous adsorptive resin, eluting by alcohol, tracking while inspecting by thin-layer chromatographic method, concentrating while recovering alcohol to obtain half-finished product with content above 35%, coating silica gel by chromatographic column, gradient eluting by different proportion acetic ether and chloroform, tracking while inspecting by thin-layer chromatographic method, de-coloring by active carbon and re-crystallizing to obtain final product with content above 98%. It's fast, cheap and convenient, has high purity and various raw materials.

Description

Technical field: [0001] The invention relates to a method for purifying resveratrol, in particular to a method for enriching and purifying resveratrol in peanut roots by using a macroporous adsorption resin. Background technique: [0002] Resveratrol is a natural active substance that has a significant health care effect on human health, and has attracted widespread attention from the international community. It has been proved by scientific research and clinical application that resveratrol has the functions of anti-cancer, anti-oxidation, preventing thrombosis, protecting the liver and scavenging free radicals. Rheumatic diseases have good preventive and therapeutic effects; in cosmetics, it has the effect of removing chloasma and whitening; it also affects lipid metabolism and platelet coagulation, and can prevent coronary heart disease and atherosclerosis diseases such as sclerosis. In recent years, it has been found that the natural plant Polygonum cuspidatum contains...

Claims

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Application Information

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IPC IPC(8): C07C39/21C07C37/82C07C37/70A61K36/48A61K125/00
Inventor 黄纪念方杰侯传伟
Owner 河南省农科院农副产品加工研究所
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