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Dry mixed suspension containing racecadotril and preparation method thereof

A technology of dry suspension and suspending agent, which is applied in the field of medicines for treating acute diarrhea, can solve the problem that the sedimentation volume ratio of racemic cadotril dry suspension cannot meet the quality requirements and the like

Active Publication Date: 2008-01-16
HAINAN SHENGKE LIFE SCI RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, Eudragit NE30D can effectively mask the bitterness of racecadotril, but it cannot make the sedimentation volume ratio of racecadotril dry suspension meet the quality requirements

Method used

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  • Dry mixed suspension containing racecadotril and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation Process:

[0021] Racecadotril was pulverized through a 140-mesh sieve, and sucrose, lactose, xanthan gum and green apple powder essence were respectively pulverized through a 100-mesh sieve. Dissolve sucralose and fruit green in an appropriate amount of water as a wetting agent. Mix racecadotril, sucrose, lactose and xanthan gum evenly, add wetting agent to make soft material, granulate through a 16-mesh sieve, dry, granulate, and finally mix evenly with green apple powder essence, and fill.

Embodiment 2

[0024] Preparation Process:

[0025] Racecadotril was pulverized through a 140-mesh sieve, and sucrose, lactose, sodium alginate and green apple powder essence were respectively pulverized through a 100-mesh sieve. Dissolve sucralose and fruit green in an appropriate amount of water as a wetting agent. Mix racecadotril, sucrose, lactose and sodium alginate evenly, add wetting agent to make soft material, granulate through a 16-mesh sieve, dry, granulate, and finally mix evenly with green apple powder essence, and fill.

Embodiment 3

[0028] Preparation Process:

[0029] Racecadotril was pulverized through a 140-mesh sieve, and sucrose, lactose, hypromellose RT-15 and green apple powder essence were respectively pulverized through a 100-mesh sieve. Dissolve sucralose and fruit green in an appropriate amount of water as a wetting agent. Mix racecadotril, sucrose, lactose and hypromellose RT-15 evenly, add wetting agent to make soft material, granulate through a 16-mesh sieve, dry, granulate, and finally mix evenly with green apple powder essence , filling.

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PUM

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Abstract

The invention provides a dry suspension agent containing racecadotril and the preparation method. The dry suspension agent provided in the invention contains a basic remedy ingredient with physiological available quantity and a carrier acceptable in pharmacy. The preparation method of the dry suspension agent containing racecadotril in the invention is characterized in that the basic remedy ingredient is firstly fixed evenly with a thinner and a suspending agent, then fixed with a wetting agent to produce granules in wet process, and finally fixed evenly with a corrective. The preparation method can hide the bitterness of medicine and guarantee the settling volume ratio of the dry suspension agent.

Description

technical field [0001] The invention relates to a medicine for treating acute diarrhea, in particular to a dry suspension with racecadotril as an active substance. technical background [0002] Diarrhea is one of the most common symptoms of the gastrointestinal tract at home and abroad, and it is one of the common diseases that seriously endanger human health, and its morbidity and mortality are very high. Currently, oral preparations for the treatment of diarrhea mainly include oral rehydration solutions and anti-peristaltic drugs. The use of oral rehydration solutions to replenish water and electrolyte depletion is the main means of antidiarrheal treatment today, but they enhance absorption without inhibiting secretion, and their onset is slow. Anti-peristaltic drugs are opioid derivatives that act by slowing down intestinal peristalsis. The main drugs are codeine phosphate, fenphenidate, and loperamide. However, they reduce bowel motility without reducing hypersecretion...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/222A61K47/38A61P1/12
Inventor 任意
Owner HAINAN SHENGKE LIFE SCI RES INST
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