Reagent kit for detecting alcoholism and alcohol addiction susceptibility

Abstract

The invention discloses a reagent box for detecting alcoholic intoxication and susceptibility to alcohol habituation. The reagent box comprises specificity primer pairs and specificity fluorescent probes for detecting position 161 SNP position in ALDH2 gene SEQ ID NO:1, and an ordinary assembly for fluorescent quantitative PCR detection. The reagent box predicts the alcoholic intoxication and susceptibility to alcohol habituation of an individual by detecting and analyzing the gene carried on position SNP on ALDH2 gene.

Description

technical field

[0001] The invention relates to a kit for detecting susceptibility to diseases, in particular to a kit for detecting susceptibility to alcoholism and alcohol addiction. Nucleotide polymorphism (SNP) loci to predict individual susceptibility to alcoholism and alcohol addiction. Background technique

[0002] Alcohol consumption is one of the important ways of life of human beings. When drinking too much alcohol or alcoholic beverages at one time, the central nervous system will change from excitement to inhibition, which is called alcoholism or ethanolism.

[0003] Alcoholism can inhibit the central nervous system, causing drowsiness and coma. Extremely high concentrations of ethanol can inhibit the medullary center and cause respiratory and circulatory failure. In addition, ethanol is metabolized in liver cells to generate a large amount of reduced nicotinamide adenine dinucleotide (NADH), which increases the ratio of NADH / NAD to the oxidized form, which can...