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Method for abstracting active ingredient of kaempferol in folium ginkgo with ultrasound wave

An active ingredient and ultrasonic technology, which is applied in the field of ultrasonic extraction of kaempferol, an active ingredient in ginkgo leaves, can solve the problems of non-selective extraction of target compounds, large industrial pollution, and long extraction time, so as to improve the processing capacity and efficiency of the equipment , wide adaptability, simple and easy operation

Inactive Publication Date: 2008-04-02
NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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Problems solved by technology

Traditional extraction methods have defects such as long extraction time, complicated process, low efficiency, large industrial pollution and no selectivity for the extraction of target compounds.

Method used

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  • Method for abstracting active ingredient of kaempferol in folium ginkgo with ultrasound wave

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Embodiment Construction

[0013] The best technical solutions obtained are:

[0014] Fresh ginkgo leaves were dried at 60°C for 24 hours, crushed, and sieved (0.45 μm) as the material. Put it into an ultrasonic extraction kettle, add 60% ethanol aqueous solution, the ratio of material to liquid (Kg:L) is 1:15, and mix. Ultrasonic generation method: other excitation ultrasonic sounding device, radial vibration columnar transducer; ultrasonic power: 100W; ultrasonic frequency: 35kHz; extraction method: interval 2min, ultrasonic action once, ultrasonic action time 5min, total extraction time 28min; extraction Temperature: 35°C; stirring method: air-lift stirring; the content of kaempferol in the extract was analyzed by high performance liquid chromatography. According to the above method, the extraction rate of the active ingredient kaempferol in the ginkgo leaves can reach 97.35%.

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Abstract

The present invention relates to a novel extraction technology of effective components in Chinese medicine. Specifically, the present invention relates to a novel method of using ultrasound to extract an effective component kaempferol in ginkgo leaves. The method uses a design program of orthogonal experiment. Based on technical parameters of the generation method, ultrasonic intensity, functional duration, functional method, solvent type, temperature of the system, and the mixing method of ultrasound through screening and extraction process, the fresh ginkgo leaves can be prepared. The ginkgo leaves are dried at a temperature of 60 DEG C for 24 hours and crushed and screened (0.45 Mu m) to be a material. The ginkgo leaves are filled into ethanol solution of 45 percent in an ultrasonic extraction reactor; the material and solution are mixed according to a ratio (Kg: L) of 1 to 15. The generation method of ultrasound comprises a simulated audible device of ultrasound and a radial cylindrical vibration transducer. The ultrasonic power is 100W, and the ultrasonic frequency is 35 kHz. In the extraction method, the ultrasound functions once with an interval of 2 minutes; the functional time of ultrasound is 5 minutes; the total extraction time is 28 minutes; the extraction temperature is 35 DEG C; the stirring method is an air-lift stirring way; the content of kaempferol in the extraction solution is analyzed by using high-efficiency liquid-phase chromatogram. With the methods, the extraction rate of the effective component kaempferol in ginkgo leaves can reach 97.35 percent.

Description

1. Technical field [0001] The invention relates to a new technology for extracting effective components of traditional Chinese medicine, in particular to a new method for extracting kaempferol, an effective component in ginkgo leaves, by ultrasonic waves. 2. Background technology [0002] The chemical meaning of extraction is to use a suitable solvent and an appropriate method to leach the required components from the sample material as completely as possible, avoiding or reducing the introduction of harmful components or other impurities. Extracting chemical components from plants for medicinal purposes has a history of nearly 5,000 years in the traditional medicine of the motherland. Traditional extraction methods can be divided into two categories according to the different energy requirements of the extraction process. One is the heating extraction method, which mainly includes different methods such as decoction extraction, reflux extraction and Soxhlet extraction; the...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30A61K36/16A61K127/00
Inventor 王强
Owner NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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