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Extractive of locust tree microellobosporia, preparation method and uses thereof

A technology of Huaier fungus and extract, which is applied in the preparation methods of peptides, chemical instruments and methods, and drug combinations, etc., can solve the problems of low purity of active components and large dosage of drugs.

Active Publication Date: 2008-06-25
QIDONG GAITIANLI MEDICINES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purity of the active ingredient is relatively low, so the dosage is high, about 25 grams of concentrate per day

Method used

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  • Extractive of locust tree microellobosporia, preparation method and uses thereof
  • Extractive of locust tree microellobosporia, preparation method and uses thereof
  • Extractive of locust tree microellobosporia, preparation method and uses thereof

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preparation example Construction

[0076] 2. The method for preparing the fungal extract of Huaier fungus provided by the present invention is simple in process, and the obtained product has high polysaccharide and binding protein content;

[0077] 3. The Huaier fungus extract provided by the present invention has a reliable curative effect for treating various types of tumors due to its high purity of active ingredients, and has almost no side effects.

[0078] 4. The method for extracting Huaier fungus provided by the present invention is beneficial to large-scale production.

Embodiment 1

[0083] Preparation of Huaier fungus extract①

[0084] Take Huaier fungus and crush it appropriately, add 12 times of water, and extract at 4-90°C for 3 times, 8h each time. After the combined extracts are concentrated to a certain density, they are centrifuged, the supernatant is ultrafiltered with an ultrafiltration membrane of 1-30 kDa, and the retentate is vacuum-dried under reduced pressure to obtain the ultrafiltration extract of Huaeria fungus by hot water extraction, total polysaccharides and The binding protein content is 78.4%.

[0085] Component analysis results:

[0086] 1. The total polysaccharide content of Huaier fungus hot water extraction ultrafiltration extract is 52.7%

[0087] 2. The combined protein content of Huaeria fungus hot water extraction ultrafiltration extract is 25.7%

[0088] 3. Molecular weight distribution of polysaccharides from Huaier fungus water-soluble extract:

[0089] (1) Chromatographic conditions

[0090] Column: TSKgel G4000PW X...

Embodiment 2

[0114] Preparation of Huaier fungus extract②

[0115] Take 1000 grams of Huaier fungus and put it into a certain container, add 18 liters of water, extract 4 times at 80 ° C, stir from time to time, and extract for 8 hours each time. Filter, combine, and concentrate to a density of 1.15 to obtain an extract. After filtering with a microporous membrane, use an 8kDa ultrafiltration membrane for ultrafiltration, and vacuum-dry the retentate under reduced pressure to obtain 37.5 grams of a water-soluble extract of Huaier fungus, with a total polysaccharide and binding protein content of 79.5%.

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Abstract

The invention discloses an extraction of sophora japonica ear fermentation substance, which is a medicine for treating oncosis, consisting free protein, polyferose and proteoglycan.The invention also discloses a preparation method and the pharmaceutical application for the extraction.The extractive of sophora japonica ear fermentation substance provided by the invention is characterized by definite active component, controllable quality, high purity active components which have a reliable treatment effect for treating all kinds of oncosis and almost no side effect.The preparation method provided by the invention has a simple technology and the products made by the method enriches active ingredient further.

Description

technical field [0001] The present invention relates to the field of plant extracts. More specifically, it relates to Huaier fungus extract and its preparation method and application. Background technique [0002] Huai Er (Huai Er) is an important folk medicinal fungus in my country, and its scientific name is Trametes robiniophila Murr. It only grows on the trunk of the old Chinese Sophora japonica. According to the classification system of Ainsworth et al. in 1973, it belongs to Basidiomycotina, Polyporaceae, Trametes. Due to the scarcity of natural Huaier, its artificial culture - Huaier fungus is mostly used now. [0003] The composition of Huaier mycelium is complex, including Huaier mycelium and culture substrate. The main active ingredient of Huaier fungus is polysaccharide and polysaccharide protein (PS-T), and its main function is to treat or adjuvantly treat tumor diseases. The previous extraction process, such as decoction and high-temperature concentration, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61P35/00C07K1/34C08B37/00
Inventor 徐无为陆正鑫
Owner QIDONG GAITIANLI MEDICINES
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