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Sterile, drop-forming, multi-phase, emulsifier-free ophthalmic product

An emulsifier and preparation technology, which is applied in the direction of non-active ingredient medical preparations, aerosol delivery, emulsion delivery, etc., can solve the problems of patient discomfort and high viscosity, and achieve comfortable compatibility, low viscosity and good phase capacitive effect

Inactive Publication Date: 2008-07-23
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this preparation, however, is that the viscosity of the preparation is very high, causing discomfort for the patient when applying the preparation, and moreover the preparation is distributed in the eye, for example by massaging, which causes additional pain sensations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] Each 100kg eye gel contains:

[0162] -0.2kg polyacrylic acid ＊1 ;

[0163] -4.0kg sorbitol;

[0164] -0.1kg Na 2 HPO 4 ×12H 2 O;

[0165] -0.0665kg sodium hydroxide;

[0166] -1kg medium chain triglycerides ＊2 ;

[0167] -Add water to 100kg.

[0168] ＊1 Available, for example, from the company Noveon Inc. under the tradename Carbopol(R) 980NF.

[0169] ＊2 Available for example under the trade name Myritol 318(R).

[0170] The viscosity of described medicament is 781mPa·s, measures according to plate-cone method, utilizes the DV-III+ type rheometer of Brookfield Company, uses CP51-axis, at 5U / min, 20 ℃, pH value is 7.0, osmotic pressure is Determined under the condition of 261mosmol / kg.

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PUM

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Abstract

The invention relates to a sterile, drop-forming, multi-phase, emulsifier-free ophthalmic product, in particular a gel product, comprising at least one liquid aqueous phase and at least one liquid hydrophobic phase, the product comprising at least one phosphate salt and having a viscosity in the range from > 200 mPa<.>s to < 2000 MPA<.>s.

Description

technical field [0001] The present invention relates to a sterile, instillable, multiphase, emulsifier-free ophthalmic preparation, especially a gel preparation. Said ophthalmic preparations can be used, for example, as artificial tears and for the treatment of "dry eyes". Background technique [0002] It is known in the art that irritated or inflamed eyes, especially "dry eyes", Keratokonjunktivitis sicca, are treated with aqueous preparations for the ailment. The formulations are usually in the form of a liquid, gel, cream or ointment. [0003] Disadvantageously, the solutions incorporate various contents that may cause allergies, produce irritation, or cause eye sensitization or incompatibility with the contents. It is also known that aqueous solutions often produce itching, burning or other unpleasant side effects when in contact with the eyes. [0004] In addition, formulations in particular in the form of gels, creams or ointments have the disadvantage of causing ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/06A61K47/32A61K47/24
CPCA61K9/0048A61K47/24A61K9/06A61K47/32A61P27/02
Inventor 古德龙·克劳斯-赫茨克里斯托弗·凯斯勒
Owner BAUSCH & LOMB INC
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