Application of plants lactobacillus in preparing medicaments for preventing and treating intestinal canal fungus infection

A Lactobacillus plantarum, fungal infection technology, applied in the direction of antifungal agents, medical raw materials derived from bacteria, pharmaceutical formulations, etc., to achieve the effects of reducing the number, reducing the germination rate, reducing the adhesion ability and invasive pathogenicity

Inactive Publication Date: 2008-08-20
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although a large number of studies at home and abroad have proved that Lactobacillus can effectively regulate the imbalance of intestinal flora, the antagonism of Lactobacillus against fungi in vivo and in vitro needs further research and application

Method used

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  • Application of plants lactobacillus in preparing medicaments for preventing and treating intestinal canal fungus infection
  • Application of plants lactobacillus in preparing medicaments for preventing and treating intestinal canal fungus infection
  • Application of plants lactobacillus in preparing medicaments for preventing and treating intestinal canal fungus infection

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Embodiment Construction

[0010] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

[0011] (1) the separation of the plant lactobacillus involved in the present invention

[0012] The Lactobacillus plantarum used in the experiment was isolated from the probiotic drug Bificon produced by Shanghai Xinyi Pharmaceutical Co., Ltd. According to the strain composition marked on the product label of the test drug, MRS medium was selected, and the contents of 5 capsules (0.2 g / grain) was dissolved in 9ml sterilized physiological sodium chloride solution, mixed thoroughly on a vortex shaker, and made ten-fold gradient dilution, and 100 μl of the last three dilutions were added to the MRS selective agar medium plate, and The L-shaped bar is evenly coated, cultured in an anaerobic culture tank at 37°C, and a single colony is isolated.

[0013] (2) Cultivation of Lactobacillus plantarum

[0014] 1. Inoculate a single colony into t...

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Abstract

The invention discloses the application of the lactobacillus plantarum to the preparation of the medication which can prevent and treat intestine epiphyte infection. The lactobacillus plantarum can notably depress the intestine candida albicans infection, especially, the prevention is very prominent.

Description

technical field [0001] The present invention relates to a new application of plantarum lactobacillus, in particular to the application of plantaractobacillus in the preparation of medicines for preventing and treating intestinal fungal infections Background technique [0002] The increase in the incidence of clinical deep fungal infection is closely related to the disturbance of intestinal flora caused by long-term use of large doses of antibiotics in patients. The side effects of antibiotics start from the disorder of the intestinal flora, marked by the increase of conditional pathogenic bacteria and the translocation of bacteria, and finally cause superinfection in the hospital with a high fatality rate. [0003] Candida albicans is the most important endogenous conditional pathogenic fungus. Studies have shown that: Candida albicans proliferates in the human gastrointestinal tract and causes deep infection is a common side effect of antibiotic treatment. Antibiotics with ...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P31/10A61K35/747
Inventor 魏泓唐欢袁静曾本华
Owner ARMY MEDICAL UNIV
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