Fipronil, chlopyrifos and production method thereof

Abstract

The invention relates to the technical field of new dosage form of microemulsion for fipronil and chlorpyrifos composite mixed insecticide, in particular to the fipronil and the chlorpyrifos mixed microemulsion and a production method thereof. The invention aims at providing a composite mixed microemulsion preparation with the fipronil and the chlorpyrifos serving as effective components and a preparation method thereof. The microemulsion preparation of the invention synthesizes and mixes the insecticides of the fipronil and the chlorpyrifos has the advantages that the readily availability and durable effectiveness are enhanced, and the drug resistance that is generated by the continuous use of a single dose to the injurious insects is weakened. The composite mixed microemulsion preparation can be used for comprehensive control of the injurious insects to a plurality of crops such as paddy rice, fruit trees, corns, cottons, tobacco, vegetables, etc.

Description

Technical field:

[0001] The invention relates to a new dosage form of fipronil, chlorpyrifos compound insecticide and microemulsion, specifically fipronil, chlorpyrifos compound microemulsion and a production method thereof. Background technique:

[0002] Fipronil is a broad-spectrum, high-efficiency insecticide first developed by the French Rhone-Planck company. The chemical name is: (R, S)-5-amino-1-(2,6-dichloromethylphenyl )-4-trifluoromethylsulfinic acid phenylpyridine-3-carbonitrile, the common name is (Fipronil), and the trade name is Regent, which is a kind of phenylpyridine insecticide. Products registered abroad include: 5% suspension concentrate, 0.3% granule, 5% seed dressing, 80% water-dispersible granule, fipronil preparation has contact killing, stomach poisoning and systemic effects, and has a wide insecticidal spectrum, which can be widely used It is used for pest control of various crops such as rice, fruit trees, corn, cotton, tobacco, vegetables, etc. It...

Examples

Embodiment 1

[0016] 12% fipronil, chlorpyrifos microemulsion

[0017] Fipronil 2%

[0018] Chlorpyrifos 10%

[0019] Toluene 5%

[0020] DMF 5%

[0021] BRT-1 15%

[0022] water to 100%

[0023] Preparation method: After dissolving fipronil and chlorpyrifos in toluene and DMF, add BRT-1 emulsifier, stir evenly, slowly add the remaining water, and fully stir until a homogeneous transparent liquid.

Embodiment 2

[0025] 22% fipronil, chlorpyrifos microemulsion

[0026] Fipronil 2%

[0027] Chlorpyrifos 20%

[0028] Toluene 15%

[0029] DMF 5%

[0030] BRT-1 18%

[0031] water to 100%

[0032] Preparation method: After dissolving fipronil and chlorpyrifos in toluene and DMF, add BRT-1 emulsifier, stir evenly, slowly add the remaining water, and fully stir until a homogeneous transparent liquid.

Embodiment 3

[0034] 45% fipronil, chlorpyrifos microemulsion

[0035] Fipronil 5%

[0036] Chlorpyrifos 40%

[0037] Toluene 5%

[0038] DMF 15%

[0039] n-Butanol 5%

[0040] BRT-1 18%

[0041] water to 100%

[0042] Preparation method: Dissolve fipronil and chlorpyrifos in toluene, DMF and n-butanol, add BRT-1 emulsifier, stir evenly, slowly add the rest of water, and fully stir until homogeneous transparent liquid.

[0043] The physical and chemical properties of the prepared microemulsion are as follows:

[0044] Appearance: light yellow or brown homogeneous transparent liquid

[0045] Transparent temperature range: -5-60°C

[0046] Stability over time: Stable for 2 years when stored at room temperature

[0047] Low temperature stability: no stratification, no precipitation, no turbidity for two weeks at -10-0°C

[0048] Emulsion stability: qualified (200 times liquid)

[0049] Microemulsion of the present invention has the following advantages compared with emulsifiable con...

Technical field:

[0001] The invention relates to a new dosage form of fipronil, chlorpyrifos compound insecticide and microemulsion, specifically fipronil, chlorpyrifos compound microemulsion and a production method thereof. Background technique:

[0002] Fipronil is a broad-spectrum, high-efficiency insecticide first developed by the French Rhone-Planck company. The chemical name is: (R, S)-5-amino-1-(2,6-dichloromethylphenyl )-4-trifluoromethylsulfinic acid phenylpyridine-3-carbonitrile, the common name is (Fipronil), and the trade name is Regent, which is a kind of phenylpyridine insecticide. Products registered abroad include: 5% suspension concentrate, 0.3% granule, 5% seed dressing, 80% water-dispersible granule, fipronil preparation has contact killing, stomach poisoning and systemic effects, and has a wide insecticidal spectrum, which can be widely used It is used for pest control of various crops such as rice, fruit trees, corn, cotton, tobacco, vegetables, etc. It...

Examples

Embodiment 1

[0016] 12% fipronil, chlorpyrifos microemulsion

[0017] Fipronil 2%

[0018] Chlorpyrifos 10%

[0019] Toluene 5%

[0020] DMF 5%

[0021] BRT-1 15%

[0022] water to 100%

[0023] Preparation method: After dissolving fipronil and chlorpyrifos in toluene and DMF, add BRT-1 emulsifier, stir evenly, slowly add the remaining water, and fully stir until a homogeneous transparent liquid.

Embodiment 2

[0025] 22% fipronil, chlorpyrifos microemulsion

[0026] Fipronil 2%

[0027] Chlorpyrifos 20%

[0028] Toluene 15%

[0029] DMF 5%

[0030] BRT-1 18%

[0031] water to 100%

[0032] Preparation method: After dissolving fipronil and chlorpyrifos in toluene and DMF, add BRT-1 emulsifier, stir evenly, slowly add the remaining water, and fully stir until a homogeneous transparent liquid.

Embodiment 3

[0034] 45% fipronil, chlorpyrifos microemulsion

[0035] Fipronil 5%

[0036] Chlorpyrifos 40%

[0037] Toluene 5%

[0038] DMF 15%

[0039] n-Butanol 5%

[0040] BRT-1 18%

[0041] water to 100%

[0042] Preparation method: Dissolve fipronil and chlorpyrifos in toluene, DMF and n-butanol, add BRT-1 emulsifier, stir evenly, slowly add the rest of water, and fully stir until homogeneous transparent liquid.

[0043] The physical and chemical properties of the prepared microemulsion are as follows:

[0044] Appearance: light yellow or brown homogeneous transparent liquid

[0045] Transparent temperature range: -5-60°C

[0046] Stability over time: Stable for 2 years when stored at room temperature

[0047] Low temperature stability: no stratification, no precipitation, no turbidity for two weeks at -10-0°C

[0048] Emulsion stability: qualified (200 times liquid)

[0049] Microemulsion of the present invention has the following advantages compared with emulsifiable con...