Medicament for treating headache and migraine, and preparation method thereof

A technology for migraine and medicine, applied in the field of medicine for treating headache and migraine and its preparation, can solve the problems affecting the development process of traditional Chinese medicine industry, less practical application, etc., and achieves reduction of crude drug dosage, small dosage of medicine, and reduction of three-waste pollution. Effect

Inactive Publication Date: 2009-04-15
孙晓波 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, supercritical CO 2 Although the extraction technology has been introduced into the research and development of traditional Chinese medicine, it is rarely used in production, which has become a factor affecting the development of the Chinese medicine industry.

Method used

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  • Medicament for treating headache and migraine, and preparation method thereof
  • Medicament for treating headache and migraine, and preparation method thereof
  • Medicament for treating headache and migraine, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] (a) Pretreatment of raw medicinal materials: crush raw medicinal materials Angelica dahurica and Rhizoma Chuanxiong into coarse powder, weigh 11000g of Angelica dahurica and 5500g of Rhizoma Chuanxiong;

[0097] (b) Extraction of effective components of raw medicinal materials: the raw medicinal materials Baizhi and Chuanxiong were respectively treated with supercritical CO 2 extraction techniques.

[0098] Put the weighed coarse powder of Angelica dahurica into CO 2 In the supercritical extraction tank, the pressure is 25Mpa, the temperature is 35°C, CO 2 The extraction was carried out for 3 hours under the flow rate of 20L / h; the analysis was carried out at a pressure of 5-6Mpa and a temperature of 40°C;

[0099] Put the weighed Ligusticum chuanxiong coarse powder into CO 2 In the supercritical extraction tank, at a pressure of 25Mpa and a temperature of 35°C, CO 2 The extraction was carried out for 3.5 hours under the condition of a flow rate of 20 L / h; the analy...

Embodiment 2

[0103] (a) Pretreatment of raw medicinal materials: crush raw medicinal materials Angelica dahurica and Rhizoma Chuanxiong into coarse powder, weigh 22000g of Angelica dahurica and 11000g of Rhizoma Chuanxiong;

[0104] (b) Extraction of effective components of raw medicinal materials: the raw medicinal materials Baizhi and Chuanxiong were respectively treated with supercritical CO 2 extraction techniques.

[0105] Put the weighed coarse powder of Angelica dahurica into CO 2 In the supercritical extraction tank, the pressure is 30Mpa, the temperature is 45°C, CO 2 The extraction is carried out for 2 hours under the condition of flow rate of 20L / h; the analysis is carried out at a pressure of 5-6Mpa and a temperature of 35°C;

[0106] Put the weighed Ligusticum chuanxiong coarse powder into CO 2 In the supercritical extraction tank, at a pressure of 30Mpa and a temperature of 45°C, CO 2 The extraction was carried out for 2 hours under the condition of a flow rate of 20 L / h;...

Embodiment 3

[0110] (a) Pretreatment of raw medicinal materials: the raw medicinal materials Angelica dahurica and Rhizoma Chuanxiong are crushed into coarse powder, and 5500g of Angelica dahurica and 2750g of Rhizoma Chuanxiong are weighed;

[0111] (b) Extraction of effective components of raw medicinal materials: the raw medicinal materials Baizhi and Chuanxiong were respectively treated with supercritical CO 2 extraction techniques.

[0112] Put the weighed coarse powder of Angelica dahurica into CO 2 In the supercritical extraction tank, the pressure is 7Mpa, the temperature is 32°C, CO 2 The extraction was carried out for 4 hours under the flow rate of 20L / h; the analysis was carried out at a pressure of 5Mpa and a temperature of 35°C;

[0113] Put the weighed Ligusticum chuanxiong coarse powder into CO 2 In the supercritical extraction tank, at a pressure of 7Mpa and a temperature of 32°C, CO 2 The extraction was carried out for 4 hours under the condition of a flow rate of 20 L...

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Abstract

The invention provides a medicine for treating headache and migraine and a preparation method thereof. The weight ratio of the dosage of an angelica dahurica crude drug to the dosage of a rhizoma ligustici wallichii crude drug of the medicine is 2 to 1; and intragastric administration of a mouse is equivalent to oral taking of 0.8 gram of the angelica dahurica crude drug per kilogram and 0.4 gram of the rhizoma ligustici wallichii crude drug per kilogram. The medicine is prepared from an effective constituent extracted from crud drugs by the supercritical CO2 extraction technology. The medicine has good treatment effect, low dosage, and no side effect, and is safe to take. The preparation method can be used for industrialized production.

Description

technical field [0001] The invention relates to a medicine for treating headache and migraine and a preparation method thereof. It belongs to the technical field of traditional Chinese medicine. Background technique [0002] Headache or migraine is one of the most common clinical symptoms. [0003] The invention patent application with application number 01823815.7 discloses a traditional Chinese medicine composition for treating nasal congestion and headache and its preparation method. The composition is made of Angelica dahurica and Chuanxiong. 100-500 parts by weight. In this application, the amount of crude drugs of Angelica dahurica and Chuanxiong is relatively large. [0004] The traditional extraction process of Angelica dahurica and Chuanxiong is steam distillation, but because the boiling point of the volatile oil of Angelica dahurica and Chuanxiong is low, this method has the defects of high extraction temperature, long extraction time, and easy destruction of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61K9/20A61K9/48A61P25/04A61P25/06
Inventor 孙晓波董方言徐惠波弥宏纪凤兰陈颖张殿文谷伟玲丁涛温富春刘嵋松
Owner 孙晓波
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