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Use of dimer hydrolysable tannins derivative in preparing medicament and diet additive for treating obesity

A technology for hydrolyzing tannin and dimer, applied in the fields of medicine and food

Inactive Publication Date: 2009-04-15
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Through the search of Science finder scholar, there is no information about the inhibitory effect and weight loss effect of this kind of dimer hydrolyzable tannin derivatives on fatty acid synthase

Method used

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  • Use of dimer hydrolysable tannins derivative in preparing medicament and diet additive for treating obesity
  • Use of dimer hydrolysable tannins derivative in preparing medicament and diet additive for treating obesity
  • Use of dimer hydrolysable tannins derivative in preparing medicament and diet additive for treating obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of compounds Gemin A, B, C and G: Take 100 grams of dried medicinal materials of Myrica japonica, add 500 milliliters of methanol to extract at room temperature for 48 hours, extract 3 times, filter and combine the extracts, concentrate and dry at 40 degrees Celsius to obtain the extraction The product was 9.0 g, and the yield was 9%. Dissolve the extract in 100 ml of hot water at 50 degrees Celsius, keep it electric and stir for 2 hours, cool to room temperature, then centrifuge or filter, and the supernatant or filtrate passes through a D101 macroporous adsorption resin column (Ф2.5×15cm), first Elute with 3 reserved volumes of water to remove water-soluble impurities such as inorganic salts, sugars, and proteins, and then elute with a gradient of 10%, 30%, 50%, 70%, 90%, and 100% ethanol-water mixed solution in volume ratio , each ratio eluted with 3 retention volumes. The 10% ethanol-water eluted part is separated by HW-40 chromatography (Ф2....

Embodiment 2

[0033] Example 2: Preparation of the compound agrimoniin: take 100 grams of dried medicinal material of Agrimonia pilosa, add 500 milliliters of methanol to extract at room temperature for 48 hours, extract 3 times, filter and combine the extracts, concentrate and dry at 40 degrees Celsius to obtain 8.5 grams of extracts , yield 8.5%. Dissolve the extract in 100 ml of hot water at 50 degrees Celsius, keep it electric and stir for 2 hours, cool to room temperature, then centrifuge or filter, and the supernatant or filtrate passes through a D101 macroporous adsorption resin column (Ф2.5×15cm), first Elute with 3 reserved volumes of water to remove water-soluble impurities such as inorganic salts, sugars, and proteins, and then elute with a gradient of 10%, 30%, 50%, 70%, 90%, and 100% ethanol-water mixed solution in volume ratio , each ratio eluted with 3 retention volumes. The 10% ethanol-water eluted part is separated by HW-40 chromatography (Ф3×50cm), and the volume ratio is...

Embodiment 3

[0035] Example 3: Preparation of the compound coriariin: take 100 grams of dried medicinal material Coriaria japonica, add 500 milliliters of methanol to extract at room temperature for 48 hours, extract 3 times, filter and combine the extracts, concentrate and dry at 40 degrees Celsius to obtain 10.6 grams of extracts, Yield 10.6%. Dissolve the extract in 100 ml of hot water at 50 degrees Celsius, keep it electric and stir for 2 hours, cool to room temperature, then centrifuge or filter, and the supernatant or filtrate passes through a D101 macroporous adsorption resin column (Ф2.5×15cm), first Elute with 3 reserved volumes of water to remove water-soluble impurities such as inorganic salts, sugars, and proteins, and then elute with a gradient of 10%, 30%, 50%, 70%, 90%, and 100% ethanol-water mixed solution in volume ratio , each ratio eluted with 3 retention volumes. The 10% ethanol-water eluted part is separated by HW-40 chromatography (Ф2.0×40cm), and the volume ratio is...

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Abstract

The invention relates to a dipolymer hydrolysable tannic derivative, which has structure of a general formula I on the right, wherein, R1, R2, R3, R4, R5, R6, R7 and R8 can be same or different, and are respectively chosen from hydrogen, methyl, ethyl, acetyl, propiono, galloyl or hexahydroxy biphenyl dimethyl acyl independently from each other, and wherein any two adjacent substituting groups can come from the same hexahydroxy biphenyl dimethyl acyl on the premise that in the R1, the R2, the R3, the R4, the R5, the R6, the R7 and the R8, at least one is galloyl or hexahydroxy biphenyl dimethyl acyl, and the glycosyl in the formula I can be same or different alpha-glucose or beta-glucose. The compound has strong ability of anti-fatty acid synthase and good anti-obesity effect in animal experiments, and the compound can be used separately, combined with other drugs or matched with pharmaceutical carriers for preparing various dosage forms such as capsule, granule, oral liquid or tablets, and the like for treating and preventing obesity, and for preparing food additives for preventing obesity.

Description

Technical field: [0001] The invention relates to the technical fields of medicine and food, in particular to a dimer hydrolyzable tannin derivative capable of inhibiting fatty acid synthase activity and reducing weight. Background technique: [0002] In recent years, with the increase of human survival age, changes in dietary life, lack of exercise and changes in the living environment, mental stress and stress responses have increased, resulting in a substantial increase in the number of people suffering from obesity, cancer and chronic and senile diseases. It has become an urgent problem to be solved. Obesity is a complex metabolic disorder determined by multiple factors, such as genes, hormones regulating energy balance, environment, lifestyle and diet are all factors that may cause obesity. But fundamentally, obesity results from a disruption of the balance between food intake and energy expenditure. Obesity seriously affects the quality of life and can lead to many di...

Claims

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Application Information

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IPC IPC(8): C07H9/02A61K31/7042A61P3/04A23L1/30A23L33/105
Inventor 刘宏伟赵文华宋晓红夏颖张英侠
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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