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34 results about "Fatty Acid Synthases" patented technology

Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.

Combination Product of Receptor Tyrosine Kinase Inhibitor and Fatty Acid Synthase Inhibitor for Treating Cancer

A pharmaceutical combination product is disclosed that comprises a receptor tyrosine kinase inhibitor and a fatty acid synthase inhibitor, and to the use thereof in the manufacture of a medicament for use in the treatment or prophylaxis of cancer.
Owner:WYETH

Therapeutic Agents - 550

A compound of formula Ior a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as Fatty Acid Synthase inhibitors, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus, cancer and infection and pharmaceutical compositions containing them.
Owner:ASTRAZENECA AB

Compositions for Enhancing the Production of PPAR and/or PPAR-Associated Factors

The present inventors focused on certain nutritional compositions known to have activity of controlling blood glucose levels. These foods were administered to rats for long periods, and real-time PCR was used to analyze the expression of genes associated with lipid metabolism in the liver and adipose tissues. As a result, the present inventors found that the expression of the PPARα gene is enhanced by these foods, and that this is accompanied by suppressed expression of fatty acid synthase and enhanced expression of a group of PPARα target genes associated with fatty acid metabolism. The present inventors also confirmed the effect of these foods in enhancing the expression of PPARγ and adiponectin, and discovered that these foods have the activity of enhancing the production of PPAR and PPAR-associated factors.
Owner:MEIJI CO LTD

Compounds, pharmaceutical compositions containing same, and methods of use for same

A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IV wherein R21=H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CH2OR25, —C(O)R25, —CO(O)R25, —C(O)NR25R26, —CH2C(O)R25, or —CH2C(O)NHR25, where R25 and R26 are each independently H, C1-C10 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R22=—OH, —OR27, —OCH2C(O)R27, —OCH2C(O)NHR27, —OC(O)R27, —OC(O)OR27, —OC(O)NHNH—R5, or —OC(O)NR27R28, where R27 and R28 are each independently H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where R27 and R28 can each optionally contain halogen atoms; R23 and R24, the same or different from each other, are C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and / or fatty acid synthase, and to stimulate CPT-1.
Owner:FASGEN

Preparation method and application of apocynum venetum extract

The invention discloses a preparation method and application of an apocynum venetum extract. The method comprises the following steps of: crushing apocynum venetum leaves, carrying out reflux extraction at room temperature or heated temperature by using ethanol, filtering, merging extracting solutions, carrying out vacuum concentration until no ethanol smell exists to obtain an ethanol extract; and diluting the ethanol extract by using water, degreasing by using petroleum ether, extracting the ethanol extract by using ethyl acetate or n-butyl alcohol as a solvent, recovering the solvent at reduced pressure, and drying to obtain the apocynum venetum extract. Proved by tests, the apocynum venetum extract obtained by using the method disclosed by the invention is an extract capable of inhibiting the activity of fatty acid synthase so as to be a natural, plant-sourced and nontoxic fatty acid synthase inhibitor.
Owner:XINJIANG ALTAY PREFECTURE GAUBAO KENDER CO LTD

Cyclopentanecarboxamide derivatives, medicaments containing such compounds and their use

The invention relates to cyclopentanecarboxamide derivatives of formula 1, to their use as Fatty Acid Synthase inhibitors, to methods for their therapeutic use and to pharmaceutical compositions containing them, wherein R1, R2, R3, LO, W, AR1, n are as defined in claim 1.
Owner:BOEHRINGER INGELHEIM INT GMBH

Inhibitor of fatty-acid synthase its preparing method and application

A depressant of fatty acid synthetase (FAS) is prepared from the shell or cake of oil-tea camellia and pharmacologically acceptable assistances through pulverizing, adding extractant, ultrasonic extracting, vacuum press filtering, concentrating, drying to obtain the extract of the shell or cake of oil-tea camellia, and mixing with said assistances. It can be used to prepare the anticancer and weight-losing medicines.
Owner:ZHEJIANG UNIV

Preparation method and application of cortex albiziae lignan glycoside monomers

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a preparation method and application of cortex albiziae lignan glycoside monomers. Eleutheroside E1 monomers with the inhibition effects on fatty acid synthase are extracted and separated from traditional Chinese medical materials of cortex albiziae. The preparation process comprises the following steps of crushing the cortex albiziae into powder; performing ethanol backflow extraction; sequentially performing extraction by ethyl acetate and water saturated n-butyl alcohol; performing elution by macroporous resin; performing silica gel column chromatographic separation; performing semi-preparation efficient liquid phase separation, reduced pressure concentration and drying to obtain afinished product. The infrared spectroscopy, nuclear magnetic resonance technology and mass spectrum are used for determining the chemical structure. The method is simple and fast; the required solvents are few; the yield is higher; higher economic values and academic values are realized.
Owner:JIANGNAN UNIV

Compositions and methods for producing lipids and other biomaterials from grain ethanol stillage and stillage derivatives

ActiveUS20180245109A1Increase profit marginDecreasing thin stillage viscosityFungiMicrobiological testing/measurementBio engineeringLysophospholipid Acyltransferase
Lipogenic yeasts bioengineered to overexpress genes for lipid production, and methods of use thereof. The yeasts are modified to express, constitutively express, or overexpress an acetyl-CoA carboxylase, an alpha-amylase, an ATP citrate lyase, a diacylglycerol acyltransferase, a fatty acid synthase, a glycerol kinase, a 6-phosphogluconate dehydrogenase, a glycerol-3-phosphate dehydrogenase, a malic enzyme, a fatty acyl-CoA reductase, a delta-9 acyl-CoA desaturase, a glycerol-3-phosphate acyltransferase, a lysophosphatidate acyltransferase, a glucose-6-phosphate dehydrogenase, a beta-glucosidase, a hexose transporter, a glycerol transporter, a glycoside hydrolase enzyme, an auxiliary activity family 9 enzyme, or combinations thereof. The yeasts in some cases are also modified to reduce or ablate activity of certain proteins. The methods include cultivating the yeast to convert low value soluble organic stillage byproducts into lipids suitable for biodiesel production and other higher value uses.
Owner:XYLOME CORP

Aliphatic acid synthase inhibitor and method for making same and uses

InactiveCN1836708AIncreased ability to inhibit fatty acid synthaseStrong inhibitory activityOrganic active ingredientsMetabolism disorderDiseaseAdjuvant
The present invention discloses one kind of fatty acid synthase inhibitor and its preparation process and application in prevention and adjuvant treatment of relevant diseases with fatty acid synthase as target. The fatty acid synthase inhibitor is prepared through reaction of tea extract or catechin compound with acid at 25-120 deg.c. The present invention has significant latent value in preparing medicine and health article for preventing and treating fatty acid synthase relevant diseases, especially for controlling weight, preventing and treating obesity relevant diseases and cancers.
Owner:田维熙

Microbiological production of short fatty acids and uses thereof

ActiveUS11078468B2Increase productionDistinct and controllable selectivityTransferasesBiofuelsMetaboliteBinding site
The present invention relates to proteins involved in fatty acid synthesis, such as fatty acid synthases (FAS) variants, comprising one or more polypeptide chains, wherein said polypeptide chain(s) comprise one or more subunits comprising a malonyl / palmitoyl transferase domain (MPT domain), acetyl transferase domain (AT domain), and ketoacyl synthase domain (KS domain), and at least one amino acid substitution in the MPT domain at a position corresponding to R130, in the AT domain at a position corresponding to I306, and / or in the KS domain, preferably in the acyl binding channel and / or at KS domain binding site to ACP, to modulate affinities of acyl intermediates, and optionally further amino acid substitution(s). The present invention relates to the respective polypeptide domains. The present invention further relates to nucleic acid molecules encoding the proteins (or the polypeptide domains) and to host cells containing said nucleic acid molecules. The present invention further relates to a method for the production of short fatty acids, CoA esters of short fatty acids, ethyl esters of short fatty acids, esters of short fatty acids with other metabolites, and / or enzyme bound short fatty acids (C6 to C12), comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention further relates to a method for the production of biofuels, flavoring compounds and / or fine chemicals, comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention also relates to the use of the proteins, nucleic acids molecule or host cells for the bulk production of short fatty acids (C6 to C12), the specific production of C6 fatty acids and / or C8 fatty acids, the bulk production of CoA esters of short fatty acids (C6 to C12), the specific production of C6-CoA esters and / or C8-CoA esters, the bulk production of ethyl esters of short fatty acids (C6 to C12), the specific production of C6 fatty acid ethyl esters and / or C8 fatty acid ethyl esters, the bulk production of esters of short fatty acids (C6 to C12) with other metabolites, the specific production of C6 fatty acid esters with other metabolites and / or C8 fatty acid esters with other metabolites, the bulk production of enzyme bound short fatty acids (C6 to C12), the specific production of enzyme bound C6 fatty acids and / or enzyme bound C8 fatty acids, the production of biofuels, fine chemicals and / or flavoring substances.
Owner:JOHANN WOLFGANG GOETHE UNIV FRANKFURT AM MAIN

Method for preparing effective part in cumin seed

The invention relates to a method for preparing an effective part in a cumin seed. The method comprises the following step: obtaining the effective part with bioactivity by virtue of a reflux and extract technology and a rapid preparing chromatographic technique, wherein the effective part can effectively inhibit the activity of fatty acid synthase, and a basis is provided for basic research on the bioactivator of Uyghur edible and pharmaceutical plant cumin and development of a corresponding product. The method is simple in preparation process, the activity of the obtained effective part for inhibiting the fatty acid synthase is high, the heat stability is good, the mass production is easy to realize, and the production cost is lowered, thus the method is ideal for preparing a biological active site. The effective part obtained by the method in the invention can be used for preparing foods and drug additives.
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI

Fatty-acid synthase inhibitor, its prepn. method, and medicine using same as active component

A fatty acid synthetase deppressant for preventing and treating the diseases associated with the fatty acid synthetase as target, especially the cancer, is prepared from the leaf of pterocarya stenoptera through extracting in the mixture of water and ethanol (or propanol).
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES

Use of dimer hydrolysable tannins derivative in preparing medicament and diet additive for treating obesity

The invention relates to a dipolymer hydrolysable tannic derivative, which has structure of a general formula I on the right, wherein, R1, R2, R3, R4, R5, R6, R7 and R8 can be same or different, and are respectively chosen from hydrogen, methyl, ethyl, acetyl, propiono, galloyl or hexahydroxy biphenyl dimethyl acyl independently from each other, and wherein any two adjacent substituting groups can come from the same hexahydroxy biphenyl dimethyl acyl on the premise that in the R1, the R2, the R3, the R4, the R5, the R6, the R7 and the R8, at least one is galloyl or hexahydroxy biphenyl dimethyl acyl, and the glycosyl in the formula I can be same or different alpha-glucose or beta-glucose. The compound has strong ability of anti-fatty acid synthase and good anti-obesity effect in animal experiments, and the compound can be used separately, combined with other drugs or matched with pharmaceutical carriers for preparing various dosage forms such as capsule, granule, oral liquid or tablets, and the like for treating and preventing obesity, and for preparing food additives for preventing obesity.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES

Fatty acid synthetase inhibitor and application for treating bacterial infection

The invention relates to a general formula I pyrrole derivation capable of inhibiting the fatty acid synthase, or all possible isomers thereof, or medicated salts or solvates thereof, wherein the definition of each substituting group in general formula I is shown in the instruction; the invention also relates to a preparation process for general formula I pyrrole derivation; the invention comprises the compound, or all possible isomers thereof, or medicated salts or medicine combinations of solvates thereof, and the usage that the compound can be used to prepare the medicaments for the bacteria infection.
Owner:INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A

Application of fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases

The invention belongs to the technical field of pharmacy, and relates to application of a fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases. The invention particularly relates to adjustment of fatty acid and triglyceride synthesis by a fresh dendrobe aqueous extract. Experimental results prove that the fresh dendrobe aqueous extract prepared by the invention can obviously inhibit the mRNA expression level of sterol regulatory element binding protein 1, diacylglycerol acyltransferase and microsome triacylglycerol transporter, and effectively regulate the biosynthesis of triglyceride; and the fresh dendrobe aqueous extract can obviously inhibit the mRNA expression levels of acetyl-CoA carboxylase, fatty acid synthase and stearoyl-CoA desaturase, and effectively regulate fatty acid synthesis; and the fresh dendrobe aqueous extract can inhibit the mRNA expression level of the FABP4, improve the peripheral insulin resistance, protect pancreatic beta cellfunctions, and improve the sensitivity of insulin, thereby inhibiting the metabolic diseases related to the FABP4; and therefore, the fresh dendrobe aqueous extract prepared by the method can be usedas the drug for treating the metabolic diseases.
Owner:安徽同济生生物科技有限公司 +1

Diagnostic Marker for Hepatocellular Carcinoma Comprising Anti-FASN Autoantibodies and a Diagnostic Composition for Hepatocellular Carcinoma Comprising Antigens Thereof

The present invention relates to an autoantibody specifically recognizing the epitope sequence of FASN (fatty acid synthase), more particularly, to the autoantibody or a fragment comprising an antigen-binding site thereof, a diagnostic composition for hepatocellular carcinoma comprising an agent capable of assessing the expression level of the autoantibody, a hybridoma cell line producing the autoantibody, a diagnostic kit for hepatocellular carcinoma comprising the composition, a method for detecting the autoantibody of hepatocellular carcinoma patient using the composition, and a method for screening a therapeutic agent for hepatocellular carcinoma by administering candidate materials for hepatocellular carcinoma treatment to confirm a reduction in the expression level of autoantibody.
Owner:KOREA RES INST OF BIOSCI & BIOTECH

Microbiological production of short fatty acids and uses thereof

ActiveUS20180066240A1Product be bulkyIncrease productionTransferasesBiofuelsMolecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic AcidMetabolite
The present invention relates to proteins involved in fatty acid synthesis, such as fatty acid synthases (FAS) variants, comprising one or more polypeptide chains, wherein said polypeptide chain(s) comprise one or more subunits comprising a malonyl / palmitoyl transferase domain (MPT domain), acetyl transferase domain (AT domain), and ketoacyl synthase domain (KS domain), and at least one amino acid substitution in the MPT domain at a position corresponding to R130, in the AT domain at a position corresponding to I306, and / or in the KS domain, preferably in the acyl binding channel and / or at KS domain binding site to ACP, to modulate affinities of acyl intermediates, and optionally further amino acid substitution(s). The present invention relates to the respective polypeptide domains. The present invention further relates to nucleic acid molecules encoding the proteins (or the polypeptide domains) and to host cells containing said nucleic acid molecules. The present invention further relates to a method for the production of short fatty acids, CoA esters of short fatty acids, ethyl esters of short fatty acids, esters of short fatty acids with other metabolites, and / or enzyme bound short fatty acids (C6 to C12), comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention further relates to a method for the production of biofuels, flavoring compounds and / or fine chemicals, comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention also relates to the use of the proteins, nucleic acids molecule or host cells for the bulk production of short fatty acids (C6 to C12), the specific production of C6 fatty acids and / or C8 fatty acids, the bulk production of CoA esters of short fatty acids (C6 to C12), the specific production of C6-CoA esters and / or C8-CoA esters, the bulk production of ethyl esters of short fatty acids (C6 to C12), the specific production of C6 fatty acid ethyl esters and / or C8 fatty acid ethyl esters, the bulk production of esters of short fatty acids (C6 to C12) with other metabolites, the specific production of C6 fatty acid esters with other metabolites and / or C8 fatty acid esters with other metabolites, the bulk production of enzyme bound short fatty acids (C6 to C12), the specific production of enzyme bound C6 fatty acids and / or enzyme bound C8 fatty acids, the production of biofuels, fine chemicals and / or flavoring substances.
Owner:JOHANN WOLFGANG GOETHE UNIV FRANKFURT AM MAIN

Fatty acid synthase inhibitors

The present disclosure relates to a method for inhibiting Fatty Acid Synthase (FASN) with a FASN inhibitor, methods for treating cancer and viral infections with a FASN inhibitor, and compounds and compositions inhibiting FASN.
Owner:THE OHIO STATES UNIV +2

Ammonia (ammonia ion) determination method and ammonia (ammonia ion) diagnosis/determination reagent kit

The invention relates to a method for determination of ammonia (ammonia ion) content by using an enzymatic colorimetric method and an enzyme couple reaction technique and composition and components of a reagent. A determination technology principle of the method is completed according to series catalytic reactions of ammonia kinase, desulphurizing biotin synthase and fatty acid synthase. The invention further relates to an ammonia (ammonia ion) diagnosis / determination reagent kit. The determination method is high in sensitivity and small in error. Therefore, the determination method and the reagent kit can be widely applied to clinical medical science / food inspection.
Owner:SUZHOU ANJ BIOTECHNOLOGY CO LTD
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