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Fatty-acid synthase inhibitor, its prepn. method, and medicine using same as active component

A fatty acid synthase and inhibitor technology, applied in the field of enzyme inhibitors and their preparation, can solve the problems of limited application value and insufficient inhibitory activity, and achieve the effects of large application value, weight control, and high fatty acid synthase inhibitory activity.

Inactive Publication Date: 2006-11-15
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common disadvantage of these inhibitors is that the inhibitory activity is not high enough, and the application value is limited, so finding fatty acid synthase inhibitors with high inhibitory activity has important practical application value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, the extraction of active substance in Yuanbao Maple Leaf

[0017] Wash the ingot maple leaves (including fallen leaves in autumn) collected in various seasons, dry them naturally or at low temperature (<50°C) and crush them, and extract the effective substances by the following method:

[0018] Mix ethanol-water mixed solvent (volume percentage of ethanol is 70%) with the above-mentioned dried maple ingots crushed at a ratio of 20:1 by weight, stir and leach for 12 hours at room temperature at 25°C, and filter; Then leached for 12 hours, then filtered, combined the two filtrates, concentrated by low-temperature evaporation (reduced pressure), removed the organic solvent therein, and obtained the active substance extract, namely the fatty acid synthase inhibitor. The extract can be further (vacuum) dried (<55° C.) to obtain a solid substance.

Embodiment 2

[0019] Embodiment 2, the extraction of active substance in Yuanbao Maple Leaf

[0020] Wash the ingot maple leaves (including fallen leaves in autumn) collected in various seasons, dry them naturally or at low temperature (<50°C) and crush them, and extract the effective substances by the following method:

[0021] Use acetone-water mixed solvent (the volume percentage of acetone is 60%) to mix with the above-mentioned dried maple ingots crushed in a ratio of 20:1 by weight, heat to reflux for 3 hours, filter; reheat to reflux under the same conditions 2 hours, filter, the two filtrates are combined, (decompression) low-temperature evaporation and concentration, remove the organic solvent therein, to obtain the effective substance water phase, the effective substance in the water phase can be further concentrated, the specific method is: first use an equal volume of The petroleum ether is extracted 3-4 times, the lipids are removed, and then extracted with ethyl acetate, the e...

Embodiment 3

[0022] Embodiment 3, the extraction of active substance in Yuanbao Maple Leaf

[0023] Wash the ingot maple leaves (including fallen leaves in autumn) collected in various seasons, dry them naturally or at low temperature (<50°C) and crush them, and extract the effective substances by the following method:

[0024] Use ethanol-water mixed solvent (volume ratio of ethanol and water is 60:40) to mix with above-mentioned crushed maple ingot dry leaf in weight ratio of 10:1, heat and reflux for 3 hours, then filter, and under the same conditions Heating under reflux for 2 hours, combining the two filtrates, (decompression) low-temperature evaporation and concentration, removing the organic solvent therein to obtain an aqueous phase containing effective substances, the effective substances in the aqueous phase can be further concentrated, the specific method is: Extract with ethyl acetate, evaporate and concentrate the ethyl acetate extract (reduced pressure) at low temperature, re...

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PUM

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Abstract

A fatty acid synthetase deppressant for preventing and treating the diseases associated with the fatty acid synthetase as target, especially the cancer, is prepared from the leaf of pterocarya stenoptera through extracting in the mixture of water and ethanol (or propanol).

Description

technical field [0001] The present invention relates to an enzyme inhibitor and its preparation method and application, in particular to a fatty acid synthase inhibitor, its preparation method and its application in the prevention and adjuvant treatment of related diseases targeting fatty acid synthase, especially The invention relates to a fatty acid synthase inhibitor, a preparation method thereof, and a cancer suppressing and weight loss drug using the fatty acid synthase inhibitor as an active ingredient. Background technique [0002] Fatty acid synthase was originally called fatty acid synthase (EC 2.3.1.85, fatty acid synthase, abbreviated as FAS), fatty acid synthase in animals is called type I FAS, and fatty acid synthase in prokaryotes and plants is called type II FAS . Basic research at home and abroad has shown that fatty acid synthase is a potential target for therapeutic purposes. [0003] So far, there are few reported fatty acid synthase inhibitors, only the...

Claims

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Application Information

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IPC IPC(8): A61K36/20A61P3/04A61P35/00
Inventor 张英侠田维熙张谨峰赵文华王喆王燕张睿李珺
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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