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Aliphatic acid synthase inhibitor and method for making same and uses

A fatty acid synthase, fatty acid synthase technology, applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of insufficient inhibitory activity and limited application value, and achieve great application value and high inhibition. active effect

Inactive Publication Date: 2009-11-04
田维熙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common disadvantage of these inhibitors is that the inhibitory activity is not high enough, and the application value is limited, so improving the inhibitory activity of fatty acid synthase inhibitors has important practical application value

Method used

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  • Aliphatic acid synthase inhibitor and method for making same and uses
  • Aliphatic acid synthase inhibitor and method for making same and uses
  • Aliphatic acid synthase inhibitor and method for making same and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1, green tea warm leaching extract was treated with 1M sulfuric acid at 100°C to prepare fatty acid synthase inhibitor

[0024]The pulverized green tea is added to 10 times the weight of 60% ethanol, soaked at 30° C. for 2 hours with stirring, and centrifuged to take the supernatant to obtain the green tea warm extract. Add an equal volume of 2M sulfuric acid to the green tea warm-leaching extract, mix the final concentration of sulfuric acid to 1M, treat at a constant temperature at 100°C, take 50 μl at regular intervals and put it into 950 μl of 50% ethanol (total green tea warm-leaching extract was diluted 40 times), and 3 μl was added to the fatty acid synthase activity assay system to measure the enzyme activity Ai. The control is the warm infusion extract of green tea diluted 40 times, 3 μl was added to the assay system of fatty acid synthase activity, and the activity AO of the enzyme was determined. Taking the activity determined by the control as 1.0, ...

Embodiment 2

[0025] Example 2, green tea warm leaching extract was treated with 1M sulfuric acid at 70°C to prepare fatty acid synthase inhibitor

[0026] Obtain green tea warm-leaching extract by the same method as Example 1, add equal volume of 2M sulfuric acid to green tea warm-leaching extract, treat at constant temperature at 70°C, take 50 μl at regular intervals and put it in 450 μl of 50% ethanol (Total green tea warm infusion extract was diluted 20 times), 5 μl was taken and added to fatty acid synthase activity assay system to measure the enzyme activity Ai. The control is the green tea warm infusion extract diluted 20 times, take 5 μl and add it into the assay system of fatty acid synthase activity, and measure the activity AO of the enzyme. The activity determined by the control is taken as 1.0, and Ai / AO is the relative remaining activity of the enzyme under the action of the treatment solution. The measurement results showed that the inhibitory activity of the treatment solut...

Embodiment 3

[0027] Example 3, green tea warm leaching extract was treated with 1M sulfuric acid at 40°C to prepare fatty acid synthase inhibitor

[0028] Obtain green tea warm-leaching extract with the same method as Example 1, add equal volume of 2M sulfuric acid to green tea warm-leaching extract, treat at a constant temperature at 40°C, take 50 μl at regular intervals and put it in 450 μl of 50% ethanol (Total green tea warm infusion extract was diluted 20 times), 10 μl was added to fatty acid synthase activity assay system, and the enzyme activity Ai was measured. The control is the green tea warm infusion extract diluted 20 times, take 10 μl and add it into the assay system of fatty acid synthase activity, and measure the activity AO of the enzyme. The activity determined by the control is taken as 1.0, and Ai / AO is the relative remaining activity of the enzyme under the action of the treatment solution. The measurement results showed that the inhibitory activity of the treatment so...

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PUM

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Abstract

The invention discloses a fatty acid synthase inhibitor, its production method and application, and its purpose is to provide a fatty acid synthase inhibitor, its production method and its prevention and adjuvant treatment of related diseases with fatty acid synthase as the target in the application. The fatty acid synthase inhibitor is obtained by treating tea warm extract or catechin compounds with acid. The preparation method of the fatty acid synthase inhibitor provided by the invention is to react the warm tea extract or catechin compounds with acid at 25-120°C to obtain the fatty acid synthase inhibitor. The present invention has significant potential applications in the prevention and auxiliary treatment of diseases targeted at fatty acid synthase, especially in the medicines and health products for weight control, prevention and auxiliary treatment of obesity-related diseases, and prevention and auxiliary treatment of cancer value.

Description

technical field [0001] The present invention relates to an enzyme inhibitor and its production method and application, in particular to a fatty acid synthase (formerly known as fatty acid synthase) inhibitor and its production method and its use in the prevention and treatment of related diseases that target fatty acid synthase Use in adjuvant therapy. Background technique [0002] At present, the incidence of obesity is on the rise no matter in developed or developing countries. Obesity is considered to be an easy-to-find, obvious, complex metabolic disorder determined by multiple factors, which can affect the physiological process of the normal function of the whole body (George L.Wolff.The Journal of Nutrition.127, 9:1871-1873( 1997)). Obesity can increase the probability of suffering from type II diabetes and cardiovascular and cerebrovascular diseases (Hubert, H.B.Annu.Rev.Public.Health.7:493-502(1986)). The health, economic and psychosocial consequences of the sprea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/82A61K31/353A61P3/04A61P35/00A61K127/00
Inventor 田维熙张睿肖文平王燕李兵辉
Owner 田维熙
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