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Inhibitor of fatty-acid synthase its preparing method and application

A fatty acid synthase and inhibitor technology, applied in the field of bioengineering, can solve problems such as scarcity of inhibitors

Inactive Publication Date: 2007-10-03
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on FAS inhibitors is still in the initial stage, and FAS inhibitors are still very scarce, so finding new and effective inhibitors has extremely high theoretical research significance and practical application potential

Method used

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  • Inhibitor of fatty-acid synthase its preparing method and application
  • Inhibitor of fatty-acid synthase its preparing method and application
  • Inhibitor of fatty-acid synthase its preparing method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of camellia oleifera shell extract

[0037] The camellia oleifera shell was dried and crushed, adding 30 times the mass of petroleum ether, ultrasonically extracted at 50°C for 45 minutes, and filtered under reduced pressure while hot to obtain a camellia oleifera shell extract solution with a flavonoid content of 0.23%.

Embodiment 2

[0038] Example 2 Preparation of Camellia oleifera Shell Extract

[0039] The camellia oleifera shell was dried and crushed, and 30 times the mass of ethanol was added, ultrasonically extracted at 50°C for 45 minutes, and filtered under reduced pressure while hot to obtain a camellia oleifera shell extract solution with a flavonoid content of 0.42%.

Embodiment 3

[0040] Example 3 Preparation of camellia oleifera shell extract

[0041] The camellia oleifera husk was dried and crushed, and 30 times the mass of water was added, ultrasonically extracted at 50° C. for 45 min, and the camellia oleifera husk extract solution was obtained by suction filtration under reduced pressure while it was hot, 0.52%.

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PUM

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Abstract

A depressant of fatty acid synthetase (FAS) is prepared from the shell or cake of oil-tea camellia and pharmacologically acceptable assistances through pulverizing, adding extractant, ultrasonic extracting, vacuum press filtering, concentrating, drying to obtain the extract of the shell or cake of oil-tea camellia, and mixing with said assistances. It can be used to prepare the anticancer and weight-losing medicines.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to an inhibitor of fatty acid synthase (FAS) and its application. Background technique [0002] Fatty acid synthase (FAS) is a key enzyme in the synthesis of fatty acids in the body and plays a key role in energy metabolism in the body. In 2000, Loftus et al. found in "Reduced food intake and bodyweight in mice treated with fatty acid synthase inhibitors" ("Science" 2000, 288(5475): 2379-2381.) Inhibition of FAS can lead to Elevated concentrations of monoacyl-CoA, which suppresses the expression of the feeding hormone neurosignal peptide Y (NPY) in the hypothalamus, thereby suppressing appetite, significantly reduced food intake and body weight in obese mice. The research of Tian Weixi etc. in " the body fat level of laying hens in different growth periods and the activity of liver fatty acid synthase " (Journal of Biochemistry, 1996,12 (2): 234-236.) also shows that the body fat leve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P3/04A61K131/00
Inventor 沈建福姜天甲陈秋平王徐卿张岳
Owner ZHEJIANG UNIV
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