Application of fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases

A technology for metabolic diseases and water extracts, which is applied to the application field of fresh Dendrobium water extracts in the preparation of drugs for treating metabolic diseases, can solve problems such as application and research of Dendrobium or Dendrobium extracts that have not yet been found, and achieve the protection of pancreatic islet beta. Effects of cell function, inhibition of metabolic diseases, and enhancement of sensitivity

Inactive Publication Date: 2020-10-16
安徽同济生生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to our literature research, we have not found the application and research of Dendrobium or Dendrobium extracts in the treatment of metabolic diseases

Method used

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  • Application of fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases
  • Application of fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases
  • Application of fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prepare fresh dendrobium aqueous extract, specifically as follows:

[0034] Preparation of fresh dendrobium water extract: take 100g of freshly picked Dendrobium huoshanense, remove the roots and leaves and keep the stem, after crushing, add 500ml distilled water to immerse the medicinal material of Dendrobium huoshanense, extract in a water bath at 80 ° C, filter and collect the filtrate, Repeat the extraction 3 times, 1 hour each time, and combine the 3 extracts. The combined extracts were concentrated under reduced pressure at 55°C to 1 / 6-1 / 8 of the original volume, and then freeze-dried to constant weight to obtain a fresh Dendrobium water extract with a mass volume concentration of 100 mg / ml.

[0035] The fresh dendrobium water extract prepared in the above example 1 with a mass concentration of 100 mg / ml was sterilized by filtration with a 0.22 μm filter membrane before the test, and then diluted to prepare a series of mass concentrations of 10 μg / mL, 100 μg / mL m...

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Abstract

The invention belongs to the technical field of pharmacy, and relates to application of a fresh dendrobe aqueous extract in preparation of drugs for treating metabolic diseases. The invention particularly relates to adjustment of fatty acid and triglyceride synthesis by a fresh dendrobe aqueous extract. Experimental results prove that the fresh dendrobe aqueous extract prepared by the invention can obviously inhibit the mRNA expression level of sterol regulatory element binding protein 1, diacylglycerol acyltransferase and microsome triacylglycerol transporter, and effectively regulate the biosynthesis of triglyceride; and the fresh dendrobe aqueous extract can obviously inhibit the mRNA expression levels of acetyl-CoA carboxylase, fatty acid synthase and stearoyl-CoA desaturase, and effectively regulate fatty acid synthesis; and the fresh dendrobe aqueous extract can inhibit the mRNA expression level of the FABP4, improve the peripheral insulin resistance, protect pancreatic beta cellfunctions, and improve the sensitivity of insulin, thereby inhibiting the metabolic diseases related to the FABP4; and therefore, the fresh dendrobe aqueous extract prepared by the method can be usedas the drug for treating the metabolic diseases.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to the application of fresh dendrobium water extract in the preparation of medicines for treating metabolic diseases. Background technique [0002] Metabolic activity is the basic life activity of the human body and the basis for maintaining body functions. With the change of people's living environment and living habits, the incidence of metabolic diseases is getting higher and higher, and the metabolic activities of the human body are affected by various factors, including environmental factors, diet factors, work and rest factors, etc. Metabolic diseases are diseases caused by metabolic problems, including metabolic disorders and vigorous metabolism. Metabolic disease does not refer to a specific disease, it is a general term for a class of diseases. Generally refers to the abnormal metabolism of some substances in the human body, such as fat, sugar, protein, purine, etc., res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P3/00A61P3/10A61P5/50A61P3/06A61K135/00
CPCA61K36/8984A61K2236/331A61K2236/51A61P3/00A61P3/06A61P3/10A61P5/50
Inventor 余茂耘梁英权韩际宏段亚君杨潇潇
Owner 安徽同济生生物科技有限公司
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