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Chinese medicine effective component composition for treating liver cancer and method for preparing the same

A technology of composition and pharmaceutical preparation, applied in the field of composition of effective parts of traditional Chinese medicine

Inactive Publication Date: 2009-04-22
刘阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about the application of the total alkaloids of Solanum nigrum and its compound preparation compatible with salidroside in the treatment of liver cancer. There is no single or compound preparation of the total alkaloids of Solanum nigrum registered in SFDA in China. None of the patents (Chinese patents, Japanese patents, Korean patents, European patents, US patents, etc.) have patent protection content similar to the present invention

Method used

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  • Chinese medicine effective component composition for treating liver cancer and method for preparing the same
  • Chinese medicine effective component composition for treating liver cancer and method for preparing the same
  • Chinese medicine effective component composition for treating liver cancer and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1 Preparation method of combination of total alkaloids of Solanum nigrum and effective parts of salidroside

[0065] method 1):

[0066] ①Extraction of total alkaloids of Solanum nigrum:

[0067] Take the whole herb and / or fruit of Solanum nigrum and add 80% ethanol solution to extract 3 times, 8 times the amount each time, recover the ethanol, concentrate to a relative density of 1.25, add 3 times the amount of 0.1mol / l hydrochloric acid solution to the concentrated solution, and stir thoroughly , refrigerated, filtered, and the filter residue was washed twice with hydrochloric acid solution, the filtrate and washing liquid were combined, and adsorbed with a weak or medium polar resin. After the resin is adsorbed, first wash the resin column / bed with water until the effluent is nearly neutral; then wash the resin column / bed with 0.1mol / l ammonia solution until the effluent is nearly colorless, and then rinse the resin column / bed with 20% ethanol solution B...

Embodiment 2

[0079] Example 2 Preparation of Injections

[0080] ①Preparation of water injection: the preparation of the combination of total alkaloids of Solanum nigrum and effective parts of salidroside was the same as Example 1 , weigh the pharmaceutical composition, add an appropriate amount of water for injection to dissolve, adjust the pH value to 6-7 with dilute hydrochloric acid, stir well, add a certain amount of activated carbon, continue to stir for half an hour, filter, pass through a 0.22μm filter membrane, and fill it. Can.

[0081] ② Preparation of freeze-dried powder injection: the preparation of the combination of total alkaloids of Solanum nigrum and effective fractions of salidroside Example 1 , weigh the pharmaceutical composition, add water for injection at 80°C to 90°C and keep stirring, after it is completely dissolved, add an appropriate amount of mannitol, stir to dissolve; adjust the pH value to 6-7, perform sterile fine filtration, and quantitatively disp...

Embodiment 3

[0083] Example 3 Preparation of solid dosage forms

[0084] ①Preparation of tablets: The preparation of the combination of total alkaloids of Solanum nigrum and effective fractions of salidroside was the same as Example 1 , weigh the pharmaceutical composition, appropriate amount of medicinal starch and other auxiliary materials, mix uniformly, granulate with starch slurry, dry and granulate, and compress into tablets to obtain the product.

[0085] ② Preparation of capsules: the preparation of the combination of total alkaloids of Solanum nigrum and effective fractions of salidroside is the same as Example 1 , weigh the pharmaceutical composition, appropriate amount of medicinal starch and other auxiliary materials, mix uniformly, pack into capsules, and obtain.

[0086] ③Preparation of powder: the preparation of the combination of total alkaloids of Solanum nigrum and effective parts of salidroside is the same as Example 1 , weigh the pharmaceutical composition and...

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Abstract

The invention discloses a traditional Chinese medicine effective part composition capable of treating liver cancer. The composition contains total alkaloids from solanum nigrum extracted from the traditional Chinese medicine Solanum nigrum and salidroside extracted from perennial herb rhodiola root, Rhodiola, Crassulaceae; and the medicine composition has remarkable treatment effect on the liver cancer and has the efficacy of protecting livers. In the effective part composition, the content of the total alkaloids from solanum nigrum of a Solanum nigrum extract is more than 50 percent, and the content of the salidroside in a Rhodiola rosea extract is more than 50 percent. In the medicine composition, the content of the total alkaloids from solanum nigrum is 2 to 6 weight portions more than 50 percent of the Solanum nigrum extract, and the content of the salidroside is 1 to 3 weight portions more than 50 percent of the Rhodiola rosea extract, wherein the preferred proportion is that the content of the total alkaloids from solanum nigrum is 2 weight portions more than 50 percent of the Solanum nigrum extract and the content of the salidroside is 1 weight portion more than 50 percent of the Rhodiola rosea extract. The invention also discloses a method for preparing the medicine composition.

Description

technical field [0001] The invention relates to a composition of effective parts of traditional Chinese medicine for treating liver cancer. The composition contains total alkaloids of Solanum nigrum extracted from traditional Chinese medicine Solanum nigrum and Rhodiola rosea extracted from the perennial herb Rhodiola of Crassulaceae Rhodiola Glycosides, the pharmaceutical composition has a significant therapeutic effect on liver cancer, and has the effect of protecting the liver. The invention also provides a preparation method of the pharmaceutical composition. It belongs to the technical field of traditional Chinese medicine. Background technique [0002] Primary liver cancer is one of the common malignant tumors in our country, and it is the second most common cancer in our country. Experts predict that the incidence of liver cancer will be the highest in the next few years. At present, about 260,000 patients die of liver cancer every year in the world, of which 42.5% ...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/00A61P1/16A61P35/00A61K36/41
Inventor 杨石李明慧
Owner 刘阳
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