Suppressor of expression of MCP-1, and ameliorating agent for inflammatory disease, pharmaceutical, supplement, food, beverage or food additive using the suppressor

An inflammatory disease, MCP-1 technology, applied in the field of beverages and food additives, food, can solve the problems of narrow application range, safety problems, difficult long-term intake, etc., and achieve the effect of excellent safety

Inactive Publication Date: 2009-06-03
ARKRAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemically synthesized medicines have the problem of side effects as described above, so it is difficult to take them for a long time
In addition, since chemically synthesized drugs have a special taste, there is a problem that, for example, the original flavor of the food is impaired when ingested together with food.
Therefore, chemically synthesized medicines may be useful, for example, in medically directed treatments, but they have problems with safety, and they cannot be used in foods, drinks, supplements, etc., and their range of applications is limited.

Method used

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  • Suppressor of expression of MCP-1, and ameliorating agent for inflammatory disease, pharmaceutical, supplement, food, beverage or food additive using the suppressor
  • Suppressor of expression of MCP-1, and ameliorating agent for inflammatory disease, pharmaceutical, supplement, food, beverage or food additive using the suppressor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] This example is an example of confirming the inhibition of MCP-1 expression by hesperetin at the gene level and protein level.

[0042] (differentiation induction of preadipocytes)

[0043] First, prepare the two types of media shown below, a differentiation-inducing medium and a differentiation-promoting medium.

[0044] differentiation induction medium

[0045] (composition: 0.25μM DEX, 0.5mM MIX, 10μg / mL insulin / DMEM containing 10% FBS)

[0046] 55 mL of FBS (fetal bovine serum (manufactured by GIBCO)) was added to 500 mL of DMEM (manufactured by SIGMA) to prepare 10% FBS-containing DMEM. 138.75 µL of DMS O (manufactured by Nacalai tesque) containing 1 mM DEX (dexamethasone) and 555 µL of PBS (manufactured by SIGMA) containing 10 mg / mL insulin were added thereto. In the insulin-containing PBS, 1N HCl was added to PBS in advance to make it acidic enough to dissolve insulin, and then the insulin was dissolved. Before use, MIX (3-isobutyl-1-methylxanthine) (manufa...

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PUM

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Abstract

The present invention discloses a suppressor of the expression of MCP-1, which is highly safe and can be applied widely to a food or the like. The suppressor comprises aurapten. Aurapten is contained in a citrus fruit such as 'Hassaku' (Citrus hassaku Hort.ex TANAKA), 'Amanatsu' (Citrus natsudaidai HAYATA), 'Natsumikan' (Citrus natsudaidai HAYATA, a variant species) and Grapefruit (Citrus paradisi). Since these citrus fruits have been eaten for many years, the suppressor is free of a safety problem. Further, when added to a food or the like, aurapten does not impair the flavor of the food or the like because of its almost tasteless and odorless properties. Still further, aurapten can be ingested over a long period even in an obese person, a diabetic patient or the like because of its low-calorie property. Aurapten can suppress the expression of MCP-1 at a gene level (see Figure 1) or a protein level.

Description

technical field [0001] The present invention relates to an MCP-1 expression inhibitor, an agent for improving inflammatory diseases using the same, a medicine, a supplement, a food, a drink, and a food additive. Background technique [0002] MCP-1 (monocyte chemoattractant protein-1, monocyte chemoattractant protein-1) is a kind of chemokine. It is mainly secreted by single cells, macrophages, fibroblasts, vascular endothelial cells, etc., and has the functions of migrating single cells or T cells, inducing the production of cytokines, and expressing adhesion factors. In addition, the receptor of MCP-1 is CCR2. Recent studies have shown that adipose tissue is the organ that secretes MCP-1, and it is known that the secretion of MCP-1 in adipose tissue increases in obese people. It is also known that MCP-1 is involved in infectious diseases, autoimmune diseases, rheumatoid arthritis, multiple sclerosis, rejection of organ transplantation, inflammatory diseases such as athero...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/16A23L1/30A23L2/00A61K31/352A61K36/00A61P3/04A61P3/06A61P3/10A61P9/10A61P9/12A61P13/12A61P25/00A61P29/00A61P31/04A61P35/04A61P37/06A61P37/08A61P43/00
CPCA61K36/752A61K31/352A23L1/3002A23L33/105A61P13/12A61P25/00A61P29/00A61P3/04A61P31/00A61P31/04A61P3/06A61P35/04A61P37/06A61P37/08A61P43/00A61P9/10A61P9/12A61P3/10
Inventor 佐佐木贵生
Owner ARKRAY INC
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