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Ceramide and collagen synthesis promoter and collagen saccharification inhibitor

A technology for ceramide and collagen synthesis, applied in skin care preparations, cosmetic preparations, active ingredients of hydroxyl compounds, etc. Synthetic effect, improving moisture retention, preventing wrinkles and sagging

Inactive Publication Date: 2012-09-12
LOTTE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is technically difficult to exhibit the same moisture retention function as the existing skin by merely applying these external preparations
In addition, there are problems that the effect is temporary, there are still doubts about its lasting effect, and the problems of dry skin, wrinkles, and sagging cannot be fundamentally solved
[0012] However, among these substances, there are also substances that are highly irritating to the skin, and some substances are insufficient in terms of safety.
In addition, there are cases where the active ingredient is directly applied to cultured cells to evaluate the effect. However, when it is intended to be used in humans or animals, it is not clear whether the active ingredient is absorbed into the body or whether the active ingredient is metabolized in the body. , it is not clear whether sufficient effect can be obtained
That is, it is difficult to say that it is good enough in terms of efficacy and safety

Method used

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  • Ceramide and collagen synthesis promoter and collagen saccharification inhibitor
  • Ceramide and collagen synthesis promoter and collagen saccharification inhibitor
  • Ceramide and collagen synthesis promoter and collagen saccharification inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 4

[0144] Tablets were formulated according to the following formula.

[0145]

[0146] The above-mentioned ingredients are uniformly mixed, and the mixed powder is compressed into tablets to make tablets.

Embodiment 5

[0148] Tablets were formulated according to the following formula.

[0149] Xylitol 80%

[0150] Lactose 8%

[0151] Hydroxypropyl Cellulose 10%

[0152] Magnesium Stearate 2%

[0153] The above-mentioned ingredients are uniformly mixed, and the mixed powder is compressed into tablets to make tablets.

Embodiment 6

[0155] Prepare the syrup according to the following recipe.

[0156] Simple Syrup 30%

[0157] Xylitol 20%

[0158] Purified water 50%

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Abstract

Disclosed is an oral preparation that is capable of enhancing skin barrier functions such as moisture retention by accelerating the synthesis of ceramide in the skin, and furthermore increases the level of collagen in the skin, prevents skin wrinkles and sagging by inhibiting the saccharification of collagen, and can be safely ingested. Specifically disclosed are a ceramide synthesis promoter, a collagen synthesis promoter, and a collagen saccharification inhibitor, which involve the oral ingestion of xylitol, that have an excellent ceramide synthesis promoting effect, collagen level increasing effect, and collagen saccharification inhibiting effect, and can be safely ingested.

Description

technical field [0001] The present invention relates to a synthesis accelerator of ceramide and collagen, and a glycation inhibitor of collagen. Background technique [0002] Conventionally, it is known that problems such as dry skin, wrinkles, and sagging occur as the skin ages and cortex deteriorates. [0003] Dry skin means that the moisture retention function of the skin is reduced, the skin is dry, and the surface is in a dry state. Dry skin is a condition that is susceptible to external stimuli, rough skin, inflammation, rashes, eczema, chapped skin, etc., and therefore needs to be improved. [0004] As a method of preventing dryness of the skin and improving dry skin, a method of applying to the skin an external preparation containing a component that suppresses moisture evaporation, such as petrolatum, mineral oil, and ceramide, is used. In addition, as a method of preventing wrinkles and sagging of the skin, a method of applying collagen to the skin is employed. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61P17/00A61P17/16A61P43/00
CPCA61K31/047A61P17/00A61P17/16A61P43/00A61K8/345A61K9/0053A61Q19/007A61Q19/08
Inventor 市川智也吉田圭司郎志村进大石祐一
Owner LOTTE CO LTD
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