Mesoporous-macroporous nanomotor as well as preparation method and application thereof

A mesoporous and nanotechnology, applied in the field of nanomotors, can solve the problems of low drug loading efficiency, difficult long-term drug release, lack of porous structure, etc., and achieve the effect of large synthesis, low cost and simple operation

Active Publication Date: 2018-12-14
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research on micro-nanomotors mainly focuses on the motion behavior and rule exploration of micro-nanomotors, and there are few studies on micro-nanomotors that can be applied to drug loading. Low loading efficiency, difficult to achieve long-term drug release
In recent years, researchers have gradually studied the drug loading performance of micro-nanomotors with mesoporous structures, but no studies have reported micro-nanomotors with hierarchical pore structures that can simultaneously load drugs of different sizes.

Method used

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  • Mesoporous-macroporous nanomotor as well as preparation method and application thereof
  • Mesoporous-macroporous nanomotor as well as preparation method and application thereof
  • Mesoporous-macroporous nanomotor as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of mesoporous-macroporous nanomotor, such as figure 1 Shown: Include the following steps:

[0029] (1) Synthesis of mesoporous silica core

[0030] 6g CTAB and 18g distilled water were prepared into a 25% solution at 60°C, 0.18g TEA (triethanolamine) was added, stirred for 1h, filtered, washed, and dried to obtain a mesoporous silica core; figure 2 It is a TEM image of the mesoporous silica core. It can be seen from the figure that the size of the mesoporous silica core is about 70-80 nm, and has a relatively regular mesoporous structure.

[0031] (2) Preparation of mesoporous-macroporous silica

[0032] The mesoporous silica inner core obtained in step (1) is formulated into an aqueous dispersion of 1ml / ml, slowly added 16ml cyclohexane and 4ml TEOS, stirred slowly for 24h, centrifuged, and washed 3 times with ethanol to obtain mesoporous Porous-macroporous silica; resulting mesoporous-macroporous silica such as image 3 Shown: by image 3 I...

Embodiment 2

[0036] A preparation method of mesoporous-macroporous nanomotor, such as figure 1 Shown: Include the following steps:

[0037] (1) Synthesis of mesoporous silica core

[0038] 3g CTAB and 6g distilled water were prepared into a solution at 60°C, 1g TEA (triethanolamine) was added, stirred for 2h, filtered, washed, and dried to obtain a mesoporous silica core;

[0039] (2) Preparation of mesoporous-macroporous silica

[0040] The mesoporous silica inner core obtained in step (1) is formulated into a 2ml / ml aqueous dispersion, slowly added 10ml cyclohexane and 2ml TEOS, slowly stirred for 10h, centrifuged, and washed 3 times with ethanol to obtain mesoporous Pores - macroporous silica;

[0041] (3) Preparation of mesoporous-macroporous nanomotors

[0042] Weigh 20mg of the mesoporous-macroporous silica obtained in step (2) and disperse it in 1.2mL of isopropanol, add 0.53mL of H2PtCl6 (0.0193M) solution, stir at room temperature for 6h, then put it into a 50°C oven for vacuu...

Embodiment 3

[0044]A preparation method of mesoporous-macroporous nanomotor, such as figure 1 Shown: Include the following steps:

[0045] (1) Synthesis of mesoporous silica core

[0046] Prepare a solution of 10g CTAB and 50g distilled water at 50°C, add 0.2g TEA (triethanolamine), stir for 10h, filter, wash, and dry to obtain a mesoporous silica core;

[0047] (2) Preparation of mesoporous-macroporous silica

[0048] The mesoporous silica inner core obtained in step (1) is formulated into a 10ml / ml aqueous dispersion, slowly added 19ml cyclohexane and 6ml TEOS, slowly stirred for 20h, centrifuged, and washed 3 times with ethanol to obtain mesoporous Pores - macroporous silica;

[0049] (3) Preparation of mesoporous-macroporous nanomotors

[0050] Weigh 20mg of the mesoporous-macroporous silica obtained in step (2) and disperse it in 1.2mL of isopropanol, add 0.53mL of H2PtCl6 (0.0193M) solution, stir at room temperature for 6h, then put it into a 50°C oven for vacuum drying; drying i...

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Abstract

The invention pertains to the field of nanomotors, and in particular relates to a mesoporous-macroporous nanomotor as well as a preparation method and application thereof. The mesoporous-macroporous nanomotor is of a hierarchical pore structure and comprises a mesoporous silica core, a macroporous layer and a metal platinum layer, wherein the surface of the mesoporous silica core is covered with the macroporous layer and the metal platinum layer. The preparation method comprises the following steps: synthesis of the mesoporous silica core, synthesis of mesoporous-macroporous silica and introduction of platinum nanoparticles on a macroporous surface so as to obtain the mesoporous-macroporous nanomotor. The mesoporous-macroporous nanomotor has the characteristic of double-layer structure, has the function of loading drugs in a hierarchical manner and is high in biocompatibility. The preparation method disclosed by the invention is simple, mild in synthesis conditions, and high in one-time synthesis capacity, and therefore, the preparation method has the broad application prospect in the biomedical field.

Description

technical field [0001] The invention belongs to the field of nanomotors, and in particular relates to a mesoporous-macroporous nanomotor and its preparation method and application. Background technique [0002] Inspired by natural molecular motors, researchers have developed a series of chemically and exogenously driven nanomotors in recent years. Existing nanomotors can be divided into three categories: rod-shaped motors, tubular motors, and spherical motors in terms of appearance; they also include some irregular-shaped motors, such as disc-shaped, spiral-shaped, capsule-shaped, and trumpet-shaped. The power source can be divided into the following two categories: one is driven by external physical stimuli, usually magnetic field, electric field, ultrasonic wave, light, etc.; the other is driven by chemical energy, usually water, hydrogen peroxide, acid solution, joint Ammonia, urea, bromine and iodide, etc. are used as fuels. Among the many driving methods, chemical cat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/04A61K47/02
CPCA61K9/5115
Inventor 万密密王琪毛春朱天宇黄洋洋
Owner NANJING NORMAL UNIVERSITY
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