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Compositions for promoting hair growth

A technology of hair growth and composition, which is applied in the field of hair growth-promoting composition, and can solve problems such as pain, cost, and hugeness

Inactive Publication Date: 2009-06-10
NOVUS INT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While hair restoration surgery can be effective, it is painful and expensive

Method used

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  • Compositions for promoting hair growth
  • Compositions for promoting hair growth
  • Compositions for promoting hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0057] Alternatively, the above-mentioned hydroxy analog of methionine may be a metal chelate containing one or more ligands having the compound represented by formula (IV) and one or more metal ions. Regardless of the embodiment, non-limiting examples of suitable metal ions include zinc ions, copper ions, manganese ions, iron ions, chromium ions, selenium ions, cobalt ions, and calcium ions. In one embodiment, the metal ion is divalent. Divalent metal ion (i.e., the net charge is 2 + Examples of ions) include copper ions, manganese ions, calcium ions, cobalt ions, and iron ions. In another embodiment, the metal ion is a zinc ion. In yet another embodiment, the metal ion is copper ion. In yet another embodiment, the metal ion is iron ion. In a further embodiment, the metal ion is calcium ion. In each embodiment, the ligand having the compound represented by formula (IV) is preferably HMTBA. In an exemplary embodiment, the metal chelate is HMTBA-Ca. In a further exemplary embodimen...

Embodiment 1

[0125] Example 1. Topical application of liposome composition to stimulate hair growth in SKH-1 alopecia mice

[0126] SKH-1 mice, an uncharacterized / unknown strain of hairless mice, are commonly used in various types of skin studies. Therefore, these mice provide an excellent system for detecting the stimulating effect of hair growth. Therefore, the ability of the liposome composition of the present invention containing a metal chelate of a methionine hydroxy analogue to treat hair loss by stimulating hair growth can be tested in SKH-1 mice.

[0127] Mouse . The study used two groups of 5-week-old SKH-1 hairless mice (Charles River, Boston, Massachusetts) matched for age, size, and sex. A plastic sheet can be used to locally apply about 20-30 μL of liposome composition to each mouse in the test group every day, with an area of ​​3x3 cm, located in the center of the back, for 7 days. The control group can be treated with vehicle alone.

[0128] Measure the hair characteristics ...

Embodiment 2

[0131] Example 2. Oral composition to improve dog's coat

[0132] The purpose of this study is to evaluate the effects of supplementing chelated organic or inorganic minerals in dog diets on immune parameters and fur mineral content of different breeds of dogs. Therefore, a diet supplemented with organic trace mineral blends (a blend containing Zn, Mn, Se, and Cu-methionine hydroxy analogs) can be supplemented with inorganic trace minerals (added with the same review) To compare their diets to understand their effects on adult dogs’ humoral immunity, Zn deposition in the fur, and serum concentrations of these trace minerals.

[0133] meal. Two diets that differ only in the form of added trace minerals can be made. The levels of Zn, Cu and Mn are the same as the usual commercial diets. "Control" diet A-supplemented with inorganic trace minerals and DL-Met so that the level of methionine is comparable to diet B supplemented with the hydroxyl analog of methionine (HMTBA). "Experiment...

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Abstract

The present invention provides compositions and methods for treating hair loss, nail brittleness and skin conditions, and for promoting or enhancing hair growth. The composition generally includes at least one methionine analog or derivative. The invention further provides structured fluid delivery systems comprising the compositions of the invention.

Description

Invention field [0001] The present invention provides compositions and methods for promoting hair growth and treating nail brittleness and skin conditions. The composition generally contains at least one methionine analog or derivative. Background of the invention [0002] Hair loss and hair loss are common troubles in mammals. More than 40% of men and nearly 15% of women will experience some degree of hair loss or hair loss. It is not until recent years that with a great deal of understanding of genetics and the chemistry of sex hormones, some reasons for hair loss have been clarified. Although hair loss may be caused by a variety of short-term conditions such as chemotherapy, fever, or dieting, the most common cause of human hair loss is a combination of genetics and hormones. In men, this type of hair loss, also known as male alopecia or androgenic alopecia, accounts for more than 95% of all hair loss. The exact cause of androgenic alopecia is still unknown. But it is clear th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/19
CPCA61K9/0019A61K9/127A61Q3/00A61K31/19A61Q19/00A61K8/447A61K9/1075A61Q7/00A61K9/0056A61K9/0014A61K9/0017A61K2800/92A61P17/14
Inventor I·阿波-内梅
Owner NOVUS INT INC
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