Habitual abortion genetic detection kit and use thereof

A habitual abortion and kit technology, applied in the direction of measuring devices, microbial determination/inspection, instruments, etc., can solve problems such as blocked homocysteine ​​clearance process, promotion of thrombosis tendency, and increased risk of habitual abortion
CN101470071AInactive Publication Date: 2009-07-01XINBAXIANG SHANGHAI MOLECULAR MEDICAL TECH SHANGHAI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XINBAXIANG SHANGHAI MOLECULAR MEDICAL TECH SHANGHAI
Publication Date
2009-07-01
Estimated Expiration
Not applicable · inactive patent
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Abstract

The invention discloses a reagent kit for detecting personal habitual abortion genetic susceptibility and an application method thereof. The reagent kit comprises six specific primer couples of single nucleotide polymorphic loci genetic type and specific fluorescence probe couples for detecting the associated antigen 4-gene (CTLA4) of cytotoxicity T lymphocyte, tumor necrosis factor-alpha gene (TNF-alpha), interleukin-6 gene (IL-6), and 5, 10-methylene tetrahydrofolate (MTHFR), and general components for fluorescence quantitative PCR detection. The reagent kit can be used to evaluate personal habitual abortion genetic susceptibility.
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Description

technical field

[0001] The present invention relates to the fields of molecular biology and medicine, more specifically, the present invention relates to a kit for detecting the genetic susceptibility of individual habitual abortion, by simultaneously detecting the cytotoxic T lymphocyte-associated antigen 4 gene closely related to habitual abortion (CTLA4), tumor necrosis factor-α gene (TNF-α), interleukin-6 gene (IL-6), 5,10-methylenetetrahydrofolate reductase gene (MTHFR) SNP The genotype of morphological loci was used to assess the genetic susceptibility of individuals to recurrent miscarriage. Background technique

[0002] If the pregnancy is less than 28 weeks and the fetal weight is less than 1000g and the termination is called abortion (Abortion). Those who terminated before 12 weeks of pregnancy were called early abortion, and those who terminated before 12 weeks to less than 28 weeks of pregnancy were called late abortion. Among them, the abortion caused by natur...

Claims

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