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Refined Yinqiao detoxification preparation and preparation method thereof

A preparation, the technology of Yinqiao, which is applied in antiviral agents, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problems of poor quality, difficult control, easy loss of volatile components, etc., and achieve the effect of stable quality enhancement and stable content

Active Publication Date: 2009-07-29
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the existing preparation process of refined Yinqiao Jiedu Tablets, the nepeta panicle medicinal material is distilled with water, and the distillation process parameters are not strictly formulated, resulting in low yield of volatile oil and poor quality, which affects the quality of the product and the efficacy of the drug
And this process is not easy to control in the production process, which is not conducive to large-scale production; volatile components are easy to lose, which affects the clinical efficacy of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This example is refined Yinqiao Jiedu Tablets (specification: each tablet contains 44mg of acetaminophen)

[0025] Its raw material composition is:

[0026] Paracetamol (72g), Campanulaceae (120g), Forsythia (200g), Tempeh (100g), Licorice (100g), Bamboo Leaf (80g), Honeysuckle (200g), Arctium (120g), Schizonepetae (80g) , Menthol (0.6g). (Total granules 408g, about 1636 pieces)

[0027] Prepared by a method comprising the following main steps:

[0028] (1), pulverizing paracetamol and bellflower: the paracetamol of formula quantity and bellflower are pulverized into fine powder respectively;

[0029] (2), extraction of nepeta panicle oil: pulverize the nepeta panicle of the formula quantity, crush the nepeta panicle of the formula quantity through 10 meshes, soak in 10 times the amount of water for 30 minutes, discard the water, heat directly through steam, and collect Aromatic water, extracted until the taste is exhausted, after the aromatic water is refined, nepe...

Embodiment 2

[0034] This example is refined Yinqiao detoxification granules (specification: 15g / bag, each bag contains 44mg of acetaminophen)

[0035] Its raw material composition is:

[0036] Paracetamol (72g), Campanulaceae (120g), Forsythia (200g), Tempeh (100g), Licorice (100g), Bamboo Leaf (80g), Honeysuckle (200g), Arctium (120g), Schizonepetae (80g) , Menthol (0.6g).

[0037] Prepared by a method comprising the following main steps:

[0038] (1), pulverizing paracetamol and bellflower: the paracetamol of formula quantity and bellflower are pulverized into fine powder respectively;

[0039] (2), extract nepeta panicle oil: crush the nepeta panicle of formula quantity through 10 mesh to 20 mesh, soak in 10 times the amount of water for 30 minutes, discard the water, directly heat with steam, collect the aromatic water, and bring it to After the taste is exhausted, the nepeta oil is obtained after the aromatic water is refined;

[0040] (3), dissolve catmint oil and menthol: the ca...

Embodiment 3

[0044] This example is refined Yinqiaojiedu capsules (specification: 0.3g / capsule, each containing 44mg of acetaminophen)

[0045] Its raw material composition is:

[0046] Paracetamol (72g), Campanulaceae (120g), Forsythia (200g), Tempeh (100g), Licorice (100g), Bamboo Leaf (80g), Honeysuckle (200g), Arctium (120g), Schizonepetae (80g) , Menthol (0.6g).

[0047] Prepared by a method comprising the following main steps:

[0048] (1), pulverizing paracetamol and bellflower: the paracetamol of formula quantity and bellflower are pulverized into fine powder respectively;

[0049] (2), extract nepeta panicle oil: crush the nepeta panicle of formula quantity through 10 mesh to 20 mesh, soak in 10 times the amount of water for 30 minutes, discard the water, directly heat with steam, collect the aromatic water, and bring it to After the taste is exhausted, the nepeta oil is obtained after the aromatic water is refined;

[0050] (3), dissolve catmint oil and menthol: the catmint oil...

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PUM

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Abstract

The invention discloses a refined lonicera-forsythia alexipharmic preparation, which is prepared by the following method: paracetamol and ballonflower are ground into fine powder respectively; schizonepeta spike is ground to be between 10 and 20 mesh, and then volatile oil is extracted; nepeta oil and menthol are dissolved in a proper amount of ethanol; the rest of medicines is added with water, decocted twice and filtered; filtrate is concentrated, dried and ground so as to obtain dry extract powder; the dry extract powder, the fine ballonflower powder, the fine paracetamol powder and subsidiary substances are granulated, added with a nepeta-oil ethanol solution and a menthol ethanol solution, well mixed and made into various orally-administrated preparations. In the refined lonicera-forsythia alexipharmic preparation, the nepeta oil as the component of the volatile oil is stable in content and beneficial to the stable quality of the preparation and the curative effect enhancement of the medicines. The invention also discloses a method for preparing the refined lonicera-forsythia alexipharmic preparation. The method is beneficial to the leaching of the volatile oil in medicinal materials so as to greatly improve the yield of the volatile oil, and has the advantages of improving the leaching rate of volatile active components, obviously increasing the content of effective substances in preparation products and strengthening the therapeutic effects of the medicines.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a refined Yinqiao detoxification preparation and a preparation method thereof. Background technique [0002] Refined Yinqiao Jiedu Tablets are recorded on page 198 of "Prescriptions of Traditional Chinese Medicine issued by the Ministry" (Volume III), with paracetamol (72g), bellflower (120g), forsythia (200g), light tempeh (100g), licorice ( 100g), light bamboo leaves (80g), honeysuckle (200g), burdock fruit (120g), nepeta ears (80g), menthol (0.6g) are raw materials, and are prepared by the following method: acetaminophen and bellflower are respectively pulverized into Fine powder, extract volatile oil from nepeta ear, dissolve nepeta ear oil and menthol with appropriate amount of ethanol; decoct the other six flavors such as forsythia with water twice, filter, combine filtrate, concentrate the filtrate into paste, add platycodon grandiflorum, ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P31/16A61P29/00A61P25/04A61P11/04A61P11/14A61K31/045A61K31/167
Inventor 卿光明余定祥钟瑛
Owner SICHUAN MEDCO PHARML
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