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Heart-protecting musk oral preparation and preparation method thereof

An oral preparation, the technology of Muxiang Baoxin, which is applied in the field of Musk Baoxin oral preparation and its preparation, can solve the problems of poor dissolution of active ingredients, unsuitable preparation, and inability to ensure stable and controllable medication.

Inactive Publication Date: 2009-10-07
北京卓越同舟药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation process of Shexiang Baoxin Pills (Chinese Pharmacopoeia 2005 Edition Part One) except ginseng is the water extract, and the other ingredients are raw medicinal materials that are directly crushed into the potion and formed into pills, so the active ingredients are poorly dissolved and the bioavailability is low, so it cannot be guaranteed. The drug is stable and controllable, and the disintegration time is slightly slower for emergency patients
Because toad venom is irritating, after oral administration, the patient will have a pungent sensation in the mouth, so the applicable crowd is limited; the main active ingredient borneol of borneol, the main active ingredient muscone in musk, the main active ingredient styrax ester of styrax, cinnamon The main active ingredient in cinnamon oil is highly volatile, and long-term storage will reduce the efficacy
[0004] The patent document with the application number 01100209 uses microwave extraction, decompression concentration, and supersonic jet technology to make nano-musk heart-protecting preparations. This process has a long production cycle and large investment, which is not suitable for the preparation of drugs containing the above raw materials.

Method used

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  • Heart-protecting musk oral preparation and preparation method thereof
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  • Heart-protecting musk oral preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] (1) The raw materials are: musk 83mg, ginseng extract 1300mg, artificial bezoar 167mg, cinnamon 830mg, storax 167mg, toad venom 100mg, borneol 625mg;

[0075] (2) Take Calculus Bezoar and grind it into a very fine powder, grind the ginseng extract, and mix the two evenly to obtain a medicinal powder;

[0076] (3) Take toad venom, grind it finely, soak it in 8 times oral water, put it into an ultrasonic extraction tank and add ethanol to make the alcohol content 60%, extract at room temperature for 0.5 hours continuously, and the extract is refrigerated at 0°C for 24 hours. Filtrate, recover the ethanol from the filtrate to the utmost, and dry to obtain the toad venom extract;

[0077] (4) Take musk, extract with 2 times of 95% ethanol continuous reflux for 4 hours, obtain musk extract, filter for later use; get cinnamon, add 8 times the amount of water, extract volatile oil by steam distillation, and obtain cinnamon volatile oil; take borneol for use Dissolve in ethano...

Embodiment 2

[0082] (1) The raw materials are: musk 200mg, ginseng extract 3100mg, artificial bezoar 400mg, cinnamon 2000mg, storax 400mg, toad venom 240mg, borneol 1500mg;

[0083] (2) Take Calculus Bezoar and grind it into a very fine powder, grind the ginseng extract, and mix the two evenly to obtain a medicinal powder;

[0084] (3) Take toad venom, grind it finely, soak it in 12 times oral water, put it into an ultrasonic extraction tank and add ethanol to make the alcohol content 90%, extract at room temperature for 1 hour continuously, and refrigerate the extract at 10°C for 36 hours. Filtrate, recover the ethanol from the filtrate to the utmost, and dry to obtain the toad venom extract;

[0085] (4) Get musk, extract with 6 times of 95% ethanol continuous reflux for 8 hours, obtain musk extract, filter for later use; get cinnamon, add 10 times of water, extract volatile oil by steam distillation, and obtain cinnamon volatile oil; get borneol for use Dissolve in ethanol to obtain bo...

Embodiment 3

[0090] (1) The raw materials are: musk 140mg, ginseng extract 2200mg, artificial bezoar 290mg, cinnamon 1350mg, storax 290mg, toad venom 170mg, borneol 1000mg;

[0091] (2) Take Calculus Bezoar and grind it into a very fine powder, grind the ginseng extract, and mix the two evenly to obtain a medicinal powder;

[0092] (3) Take toad venom, grind it finely, soak it in 10 times oral water, put it into an ultrasonic extraction tank, add ethanol to make the alcohol content 75%, extract at room temperature for 0.8 hours continuously, and refrigerate the extract at 5°C for 30 hours. Filtrate, recover the ethanol from the filtrate to the utmost, and dry to obtain the toad venom extract;

[0093](4) Take the musk, extract with 4 times of 95% ethanol under continuous reflux for 6 hours to obtain the musk extract, and filter it for subsequent use; take the cinnamon, add 9 times the amount of water, and extract the volatile oil by steam distillation to obtain the cinnamon volatile oil; t...

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Abstract

The invention discloses a heart-protecting musk oral preparation and a preparation method thereof. The invention is characterized in that musk, artificial cow-bezoar, Chinese cinnamon, storax and toad venom are extracted to obtain an extract, the extract is mixed with a ginseng extract and borneol, and medical auxiliary materials are added to be prepared into an oral preparation; the toad venom is controlled at 2-4 mu g / bottle according to the total amount of the bufogenin and the cinobufagin; and the pharmacological tests show that each group of the preparations has good action of curing the heart disease and especially has the action of promoting the angiogenesis of the heart.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a musk-protecting heart oral preparation and a preparation method thereof Background technique [0002] Shexiang Baoxin Pill is based on the angina pectoris caused by the "blocked heart veins" and the pathogenesis "cold evil internal offense" in traditional Chinese medicine. , ginseng extract, toad venom, artificial bezoar, cinnamon, styrax, and borneol are used as raw materials to make pharmaceutical preparations for treating cardiovascular diseases; Shexiang Baoxin pills have the effects of aroma, warming, nourishing qi and strengthening the heart, and are mainly used for myocardial ischemia. angina pectoris, chest tightness and myocardial infarction; with the in-depth research on its chemical composition and pharmacology, its clinical application continues to expand. Studies have shown that Shexiang Baoxin Pills can also treat chronic ...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61P9/10A61K31/045A61K35/413A61K35/55A61K35/56A61K35/65
Inventor 王爱民李伟
Owner 北京卓越同舟药物研究院有限公司
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