Drug composition with the effect of anti-lung cancer and application in preparing anti-lung cancer drug

A technology of anti-lung cancer drugs and compositions, which is applied in the direction of drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., and can solve problems such as inconvenient carrying and taking, failure to meet market demand, and difficulty in quality control

Active Publication Date: 2009-10-07
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, most anti-lung cancer compound prescriptions in clinical practice are mostly used as decoctions, which are inconvenient to carry and take; or directly made into oral preparations after ext...

Method used

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  • Drug composition with the effect of anti-lung cancer and application in preparing anti-lung cancer drug
  • Drug composition with the effect of anti-lung cancer and application in preparing anti-lung cancer drug
  • Drug composition with the effect of anti-lung cancer and application in preparing anti-lung cancer drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Weigh 150g of Prunella vulgaris, 300g of Hedyotis diffusa, 300g of Agrimony, 150g of Eclipta, and 120g of Cornus officinalis, and extract twice with 95% ethanol for 2 hours each time, add 12 times the amount for the first time, and add 8 times the amount. The dregs are extracted twice with 60% ethanol under reflux, each time for 2 hours, adding 12 times the amount for the first time, and adding 8 times the amount for the second time. After filtration, the filtrates were combined, ethanol was recovered under reduced pressure, and concentrated to 4000 mL. Add the concentrated solution to 1500 g of the treated HP20 macroporous adsorption resin, elute with distilled water and 10% ethanol respectively and discard the eluent, elute with 50% ethanol that is 8 times the volume of the resin bed, and collect the 50% ethanol wash. Remove the liquid, concentrate under reduced pressure, and dry in vacuo to obtain 42.1 g of extract I, then elute with 95% ethanol 10 times the volume ...

Embodiment 2

[0072] Weigh 150g of Prunella vulgaris, 300g of Hedyotis diffusa, 300g of Agrimony, 150g of Eclipta, and 120g of Cornus officinalis, and extract twice with 95% ethanol for 2 hours each time, add 12 times the amount for the first time, and add 8 times the amount. The dregs are extracted twice with 60% ethanol under reflux, each time for 2 hours, adding 12 times the amount for the first time, and adding 8 times the amount for the second time. After filtration, the filtrates were combined, ethanol was recovered under reduced pressure, and concentrated to 4000 mL. Add the concentrated solution to 1500 g of the treated HP20 macroporous adsorption resin, elute with distilled water and 10% ethanol respectively and discard the eluent, elute with 50% ethanol that is 8 times the volume of the resin bed, and collect the 50% ethanol wash. Remove the liquid, concentrate under reduced pressure, and dry in vacuo to obtain 42.1 g of extract I, then elute with 95% ethanol 10 times the volume ...

Embodiment 3

[0075] Weigh 200g of Prunella vulgaris, 200g of Hedyotis diffusa, 200g of Agrimony, 200g of Eclipta, and 120g of Cornus officinalis, and reflux extract with 95% ethanol for 4 times, each time for 1 hour, add 12 times the amount for the first time, and add 12 times the amount for the other three times. 8 times the amount. The medicinal dregs were extracted with 75% ethanol for reflux extraction 4 times, each time for 1 hour, adding 12 times the amount for the first time, and adding 8 times the amount for the other three times. After filtration, the filtrates were combined, ethanol was recovered under reduced pressure, and concentrated to 4000 mL. Add the concentrate to 1000 g of the treated SP825 macroporous adsorption resin, elute with distilled water and 10% ethanol respectively and discard the eluate, elute with 50% ethanol that is 8 times the volume of the resin bed, and collect the 50% ethanol wash. Remove the liquid, concentrate under reduced pressure, and dry in vacuo t...

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PUM

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Abstract

The invention relates to a drug composition with the effect of anti-lung cancer and an application in preparing anti-lung cancer drug; the raw materials of the drug are as follows by weight portions: 10 to 30 of common selfheal fruit-spike, 10 to 50 of spreading hedyotis herb, 10 to 50 of hairyvein agrimonia herb and bud, 10 to 30 of yerbadetajo herb and 6 to 20 of dogwood. The drug extract is prepared by the following method which comprises the steps of: (1) extracting with 75 percent to 95 percent of alcohol for 1 to 4 times with 1 to 3 hours for each time; (2) carrying out extraction to the drug dreg extracted by the step (1) with 50 percent to 75 percent of alcohol for 1 to 4 times with 1 to 3 hours for each time; (3) combining the extracts of the (1) and (2), recovering the alcohol, reducing pressure and concentrating to obtain macroporous absorption resin column on the concentrated solution, using 40 percent to 60 percent of alcohol for elution to obtain extract I and using 70 percent to 90 percent of alcohol for elution to obtain extract II; and (4) mixing the extract I and the extract II to obtain active components. The application of the drug composition in preparing the drug for anti-lung cancer has stronger capacity to inhibit the proliferative activity of human lung cancer cell SPC-A-1.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a pharmaceutical composition with an anti-lung cancer effect, and an application of the pharmaceutical composition in preparing anti-lung cancer drugs. Background technique [0002] Lung cancer is one of the most common malignant tumors in the world today. Its incidence and mortality rate have ranked first among common tumors, and it has become a major killer of human health. In recent years, the morbidity and mortality of lung cancer have been on the rise from a global perspective, and are increasing at a rate of 0.5% per year. In my country, lung cancer is the most common malignant tumor in cities. In the past 20 years, the mortality rate of lung cancer in cities has more than doubled. With the increase in the number of young people smoking in my country, the incidence and mortality of lung cancer in my country will continue to rise in the next century. At present...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P35/00
Inventor 陈彦贾晓斌邵振中朱启勇
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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