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Heart ischemia reperfusion model of living piglet and method for establishing model

A technology for cardiac ischemia and establishment of methods, which is applied in medical science, veterinary instruments, veterinary surgery, etc., can solve the problems of few reports, and achieve the effect of extensive resources, large number of groups, and reasonable cost of animal raw materials

Inactive Publication Date: 2009-12-16
TIANJIN AGRICULTURE COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in our country, the main value of pigs is still reflected in the value of meat, and the research on the functional development of pig organs, especially the research on myocardial ischemia and reperfusion in live piglets is rarely reported.

Method used

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  • Heart ischemia reperfusion model of living piglet and method for establishing model
  • Heart ischemia reperfusion model of living piglet and method for establishing model

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Experimental program
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Embodiment Construction

[0019] The present invention will be described in detail below in conjunction with specific embodiments.

[0020] 1. Piglet rearing before surgery

[0021] The piglets were fed according to the international standards for experimental animals.

[0022] Live piglets of Landrace and Yorkshire breeds in the nursery period were selected as experimental objects, and the specific feeding methods were as follows:

[0023] 1.1 The feeding environment of experimental piglets

[0024] The piglets are raised in the nursery, free to eat, and provided with sufficient clean drinking water from duckbill drinking fountains. The temperature of the pig house is 22-25 °C, the humidity is 65-68%, and it is cleaned twice a day. The ventilation and lighting in the house are good. Use Padunxiao and Mieducarb for disinfection, 2 to 3 days / time.

[0025] 1.2 Nutrition ratio of experimental piglet diet

[0026] The full-price grains were prepared according to the American NRC Pig Nutritional Requi...

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Abstract

The invention discloses a heart ischemia reperfusion model of a living piglet and a method for establishing the model, and aims to provide a heart ischemia reperfusion model and a method for establishing the model with universal animal variety, low cost and convenient operation by using the living piglet as an object. The living piglet is subjected to thoracotomy, then the heart coronary artery is subjected to left circumflex ligation, and later a ligation line is released so as to obtain the heart ischemia reperfusion model of the living piglet. The constructed heart ischemia reperfusion model of the living piglet provides a novel animal species for medical experiment, namely an experimental piglet model, and becomes an important animal model for researching human diseases. Because the piglet species for experimental selection has wide resource and large group number, the animal raw material cost is proper. The established open chest coronary artery ligation heart ischemia operation method for the living piglet provides feasibility for acquiring large amount of related test data of the piglet heart in future, is convenient to operate, and has research and reference value of clinical medicine.

Description

technical field [0001] The invention relates to a living piglet cardiac ischemia-reperfusion model and a method for establishing the model. Background technique [0002] The utilization of animal organs has been a research hotspot for nearly half a century, and exciting results have been achieved. Animals will experience ischemia-reperfusion injury (IRI) in the process of organ reutilization. Ischemia-reperfusion injury refers to reperfusion of tissues and organs after ischemia, which not only fails to restore the function of tissues and organs, but aggravates the dysfunction and structural damage of tissues and organs. Ischemia-reperfusion injury can occur in many important organs, including the heart, liver, lung, kidney, and gastrointestinal tract. If animal organs are transplanted, the transplanted organs will experience a second blow with the opening of blood flow after ischemic injury. Can further aggravate organ damage. [0003] The heart is an organ with high oxy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/027A61D1/00A61D7/00
Inventor 郭亮赵伟
Owner TIANJIN AGRICULTURE COLLEGE
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