Imaging of activated vascular endothelium using immunomagnetic mri contrast agents

A contrast agent and in vivo imaging technology, applied in the field of diagnostic imaging technology, can solve problems such as affecting efficacy and low blood half-life

Inactive Publication Date: 2010-01-27
VERIDEX LCC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although molecular conjugation and delivery of the agent to the target site are accomplished, the agent becomes very large (>65nm) and exhibits a very low blood half-life (<50 minutes) due to bioconjugation, which may significantly Affects Potency in Humans

Method used

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  • Imaging of activated vascular endothelium using immunomagnetic mri contrast agents
  • Imaging of activated vascular endothelium using immunomagnetic mri contrast agents
  • Imaging of activated vascular endothelium using immunomagnetic mri contrast agents

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Embodiment Construction

[0036] The present invention uses a coated magnetic particle comprising a nanoparticle core of magnetic material, and a base coating material on the magnetic core (US 6,365,362). These magnetic particles are characterized by particularly low non-specific binding. The magnetic core material of the described particles may comprise at least one transition metal oxide, and a suitable substrate coating material comprising a protein. Proteins suitable for coating magnetic particles include, but are not limited to, bovine serum albumin and casein. The additional coating material may be the original coating protein, or a member of a specific binding pair coupled to the substrate material on the magnetic core. Exemplary specific binding pairs include biotin-streptavidin, antigen-antibody, receptor-hormone, receptor-ligand, agonist-antagonist, lectin-carbohydrate, protein A-antibody Fc and avidin-biotin. The members of the specific binding pair can be coupled to the substrate coating...

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Abstract

lmmunomagnetic nanoparticles are used as a contrast agent for enhancing medical diagnostic imaging such as magnetic resonance imaging (MRI). The present invention is directed to methods of making targeted MRI contrast agents from immunomagnetic particles, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically can afford enhanced blood clearance rates and distribution. The ability to use the contrast agents im MRI provides a tool in the diagnosis and treatment of several disease states.

Description

[0001] Cross References to Related Applications [0002] This application is a non-provisional application, and US Provisional Application No. 60 / 856,127, filed November 2, 2006, is hereby incorporated by reference and claims partial priority. technical field [0003] The present invention generally relates to in vivo diagnostic imaging using nanoparticles. More specifically, the present invention relates to a diagnostic imaging technique that enables imaging of disease states with targeted contrast agents that are functionalized in a coating process that incorporates targeting moieties formed from nanoparticles. These contrast agents are suitable for magnetic resonance imaging in the assessment, diagnosis and treatment of disease states such as but not limited to cancer, cardiovascular disease, cerebrovascular disease, peripheral vascular disease, autoimmune disease and all inflammatory diseases. Background technique [0004] The present invention relates to immunomagneti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055
CPCA61K49/1869A61K49/16A61K49/1875B82Y5/00A61B5/055
Inventor G·V·多伊尔
Owner VERIDEX LCC
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