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Dehydration methylate of quinolinone alkaloid derivative and preparation method and application

A technology of alkaloid derivatives and quinolinones is applied in the application field of microbial pesticides and insecticides, which can solve problems such as insecticides that have not yet been seen, and achieve the effect of broad application prospects.

Active Publication Date: 2010-04-07
OCEAN UNIV OF CHINA
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  • Claims
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Problems solved by technology

However, so far, no medicinal value microbial pesticide insecticides have been obtained from marine fungi.

Method used

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  • Dehydration methylate of quinolinone alkaloid derivative and preparation method and application
  • Dehydration methylate of quinolinone alkaloid derivative and preparation method and application
  • Dehydration methylate of quinolinone alkaloid derivative and preparation method and application

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Embodiment Construction

[0009] In preparing the compounds of the present invention, the following steps are taken:

[0010] (1) Carry out strain culture to marine fungus (Penicillium sp.ZZF32#) in strain culture medium earlier, the culture medium used contains glucose 1.0% (percentage by weight, the same below), yeast extract 0.1%, peptone 0.2%, Agar 1.0%, sodium chloride 0.3%, the rest is water. When used, it was made into a test tube slant culture medium, and the above-mentioned fungal strains were cultured at 30° C. for 5 days.

[0011] The strain medium contains 0.1%-5.0% of glucose, 0.01%-1% of yeast extract, 0.01%-1% of peptone, 0.1%-3.0% of agar, 0.05%-5% of sodium chloride and the rest is water. The culture temperature is 15-35° C., and the culture time is 3-10 days.

[0012] (2) The above-mentioned cultured fungal strains are fermented and cultivated. The fermentation medium used contains 1.0% glucose, 0.1% yeast extract, 0.2% peptone, 0.3% sodium chloride, and the rest is water. The funga...

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Abstract

The invention relates to a dehydration methylate of a quinolinone alkaloid derivative and a preparation method and application. The preparation method is characterized by first carrying out strain culture on marine fungi in a strain medium, then carrying out fermentation culture in a fermentation medium, filtering obtained fermentation liquid to obtain thalli and extracting the obtained thalli by an organic solvent; carrying out chromatographic separation on extraction liquid after the extraction liquid is concentrated, concentrating obtained eluent to obtain yellow powder, namely 2-pyrrolyl-3-carboxyl-4-quinolinone; and adding a methylation reagent and a catalyst into acetone solution in which the 2-pyrrolyl-3-carboxyl-4-quinolinone is dissolved for reaction, and then obtaining the dehydration methylate of the quinolinone alkaloid derivative after reaction. The compound of the invention has strong effect on killing cotton aphids, plutella xylostella and heliothis virescens, can be used as a microbial pesticide and has extensive application prospect. In addition, the raw materials of the compound can be produced in large scale.

Description

technical field [0001] The invention relates to a dehydration methylated product penicinotam of a quinolinone alkaloid derivative (2-pyrrolyl-3-carboxy-4-quinolinone) extracted from the thalline of marine endophytic fungi and a preparation method thereof And as the application of microbial pesticide insecticide. Background technique [0002] Since penicillin was prepared from fungi in 1929, fungal metabolites have become a rich source of drugs, and the vast majority of clinically used antibiotics are derived from fungi and bacteria. The metabolites of fungi also have other medicinal value, such as anti-tumor, treatment of cardiovascular diseases, enzyme inhibitors, etc. Due to the particularity of the marine environment and the functions of microorganisms in the ecosystem, marine microorganisms have developed unique metabolic methods, and also provide metabolites that terrestrial microorganisms cannot provide. People place great importance on finding new specific drugs from...

Claims

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Application Information

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IPC IPC(8): C07D471/14C12P17/18A01N43/90A01P7/04C12R1/80
Inventor 林永成邵长伦王长云周世宁顾玉诚佘志刚
Owner OCEAN UNIV OF CHINA
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