Pharmaceutical composition for treating liver diseases and prepration method thereof

A composition and drug technology, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as single therapeutic effect.

Active Publication Date: 2010-06-09
湖南省中药提取工程研究中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Resveratrol has not been directly used in the treatment of liver diseases in China, but it has antioxidant effect. There ...

Method used

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  • Pharmaceutical composition for treating liver diseases and prepration method thereof

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Embodiment 1

[0026] The extraction method of embodiment 1 pharmaceutical raw material of the present invention

[0027] Weigh the raw materials: 500g of Huangcao, 1000g of Polygonum cuspidatum, and 1000g of Schisandra chinensis.

[0028] A: Add 10 to 20 times water to extract 2 to 3 times, 3 to 5 hours each time, combine the extracts, filter or centrifuge, concentrate to a relative density of 1.0 to 1.4, add ethanol or methanol and other organic solvents to precipitate, and filter , the filtrate is concentrated to obtain the extract of C. chinensis, the extraction rate is 10%, wherein the content of quercetin > 5%, and the content of gallic acid > 3%, and it is used for future use.

[0029] B: Enzymolysis and fermentation of Polygonum cuspidatum by distiller’s yeast (purchased from Angel Yeast Co., Ltd.), extraction with 10 to 20 times of ethanol or methanol for 2 to 3 times, each time for 3 to 5 hours, combining the extracts, filtering or centrifuging, The filtrate was concentrated to ob...

Embodiment 2

[0032] The extraction method of embodiment 2 pharmaceutical raw materials of the present invention

[0033] Weigh the raw materials: 500g of Huangcao, 1000g of Polygonum cuspidatum, and 1000g of Schisandra chinensis.

[0034] A: Add an appropriate amount of C. chinensis and add 10-20 times of water to extract 2-3 times, each time for 3-5 hours, combine the extracts, filter or centrifuge, concentrate to a relative density of 1.0-1.4, add ethanol or methanol and other organic solvents to precipitate , filtered, and the filtrate was concentrated to obtain a proportioned extract of C. chinensis, with an extraction rate of 10%, wherein the content of quercetin was > 5%, and the content of gallic acid > 3%, and was set aside.

[0035] B: Proper amount of Polygonum cuspidatum is subjected to enzymatic hydrolysis and fermentation by koji yeast, extracted with 10-20 times of ethanol or methanol for 2-3 times, each time for 3-5 hours, the extracts are combined, filtered or centrifuged, ...

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Abstract

The invention provides a pharmaceutical composition for treating liver diseases, which is prepared by mixing penthorum chinense pursh proportional extract, giant knotweed rhizome extract and Chinese magnoliavine fruit extract, and the invention further provides a preparation method of the pharmaceutical composition. All the extracts are mutually compatible for use, thereby playing the synergy, realizing clear efficacy and strong controllability, and providing a new clinical choice.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating liver diseases, that is, to an extract composition prepared from extracts extracted from Chinese medicinal materials as raw materials and a preparation method thereof. Background technique [0002] Liver disease is a digestive system disease. There are 350 million chronic hepatitis B virus (HBV) carriers in the world, accounting for 5% of the world's population. The HBV carrier rate in Asia and Africa is 8% to 15%. In my country, there are 120 million hepatitis B carriers. , 25 million hepatitis B patients, 500,000 new patients every year. Such a huge patient group has given birth to a huge hepatitis B drug market. According to figures released by the Chinese Pharmaceutical Association, the hepatitis drug market in 2005 was US$5 billion, and by 2008 the global hepatitis drug market could reach US$6.275 billion. In m...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P1/16A61P31/14A61P31/20
Inventor 曾建国铃木丸荣贺晓华
Owner 湖南省中药提取工程研究中心有限公司
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