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Omeprazole complex preparation and preparation method thereof

A technology of omeprazole and compound preparation, applied in the field of pharmaceutical preparations, can solve the problems of delaying the initial inhibition of absorption and the like

Inactive Publication Date: 2010-06-23
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because proton pump inhibitors are easily degraded in acidic environments, enteric coating is usually used to protect the drug from gastric acid damage, but it delays the absorption of the drug and the initial inhibition of gastric acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: specification 1000 pieces

[0010] Prescription: Omeprazole 20g

[0011] Sodium bicarbonate 1100g

[0012] Lactose 25g

[0013] Microcrystalline Cellulose 40g

[0014] Mannitol 25g

[0015] Crospovidone 10g

[0016] Aspartame 0.1g

[0017] Fruit milk essence 0.1g

[0018] Micronized silica gel 0.75g

[0019] Magnesium stearate 0.75g

[0020] 30% ethanol solution of 8% povidone appropriate amount

[0021] Preparation method: take the prescribed amount of omeprazole, sodium bicarbonate, microcrystalline cellulose, sodium carboxymethyl starch, lactose, mannitol, and crospovidone, sieve, mix well, and add an appropriate amount of 8% povidone Add 40% ethanol solution to the above mixture to make a soft material, granulate through a 20-mesh sieve, dry at 60°C for 6 hours, granulate with a 20-mesh sieve, add fruit milk essence, magnesium stearate, aspartame, and micro-powdered silica gel, Use a...

Embodiment 2

[0022] Embodiment 2: 1000 pieces of specifications

[0023] Omeprazole 40g

[0024] Sodium bicarbonate 1100g

[0025] Microcrystalline Cellulose 50g

[0026] Sodium carboxymethyl starch 2.5g

[0027] Lactose 20g

[0028] Mannitol 20g

[0029] Crospovidone 9g

[0030] Aspartame 0.1g

[0031] Fruit milk essence 0.1g

[0032] Micronized silica gel 0.75g

[0033] Magnesium stearate 0.75g

[0034] 30% ethanol solution of 8% povidone appropriate amount

[0035] Preparation method: take the prescribed amount of omeprazole, sodium bicarbonate, microcrystalline cellulose, sodium carboxymethyl starch, lactose, mannitol, and crospovidone, sieve, mix well, and add an appropriate amount of 8% povidone Add 40% ethanol solution to the above mixture to make a soft material, granulate through a 20-mesh sieve, dry at 60°C for 6 hours, granulate with a 20-mesh sieve, add fruit milk essence, magnesium stearate, aspartame, and micro-powdered silica gel, Use a 30-mesh sieve to sieve the ...

Embodiment 3

[0036] Embodiment 3: 1000 pieces of specifications

[0037] Prescription: Omeprazole 20g

[0038] Sodium bicarbonate 1100g

[0039] Lactose 25g

[0040] Microcrystalline Cellulose 40g

[0041] Mannitol 25g

[0042] Crospovidone 10g

[0043] Aspartame 0.1g

[0044] Fruit milk essence 0.1g

[0045] Micronized silica gel 0.75g

[0046] Magnesium stearate 0.75g

[0047] 30% ethanol solution of 8% povidone appropriate amount

[0048] Preparation method: take the prescribed amount of omeprazole, sodium bicarbonate, microcrystalline cellulose, sodium carboxymethyl starch, lactose, mannitol, and crospovidone, sieve, mix well, and add an appropriate amount of 8% povidone Add 40% ethanol solution to the above mixture to make a soft material, granulate through a 20-mesh sieve, dry at 60°C for 6 hours, granulate with a 20-mesh sieve, add fruit milk essence, magnesium stearate, aspartame, and micro-powdered silica gel, U...

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PUM

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Abstract

The invention relates to the field of medicinal preparation, in particular to omeprazole complex preparation and a preparation method thereof. The invention is characterized in that unit preparation contains 10-40mg omeprazole, 0.5-1.5g sodium bicarbonate and proper amounts of auxiliary materials. More specifically, the unit preparation contains 20mg or 40mg omeprazole and 1.1g sodium bicarbonate, wherein the omeprazole and the sodium bicarbonate are the main medicine components. The invention additionally discloses the preparation method. The invention has the advantages that the preparation takes effect rapidly, the side effect is small, and the preparation can be used to cure diseases such as hyperchlorhydria, gastroesophageal reflux disease, erosive esophagitis (the preparation being used as short-term curing medicine), active gastric ulcer, active duodenal ulcer (the preparation being used as short-term curing medicine) and the like.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an omeprazole compound preparation and a preparation method thereof. Background technique [0002] Digestive system diseases are common diseases and frequently-occurring diseases. According to statistical data, the incidence of gastrointestinal diseases in the world accounts for about 12% of the population. With the continuous development of social economy and the continuous increase of people's study, work, life and psychological pressure, the incidence of digestive system diseases in our country is also increasing year by year. According to the latest survey by an authoritative organization, the average incidence of digestive system diseases in my country has risen to 15.68% in 2003. Beijing, Shanghai, Guangzhou, Tianjin, Shenzhen and other large cities with relatively developed economies, fierce competition, and high work pressure, The incidence of digestive system ...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K33/10A61P1/04
Inventor 王翰斌王翰腾
Owner BEIJING HOPE HUGE PHARM SCI
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