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A compound preparation containing ilaprazole sodium

A technology of ilaprazole sodium and compound preparation, applied in the field of ilaprazole sodium compound preparation and preparation thereof, can solve the problems of slow onset of action, serious adverse reactions and the like

Active Publication Date: 2016-06-29
珠海保税区丽珠合成制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the adverse reactions are serious and the onset is slow
There is no compound preparation of ilaprazole sodium and sodium bicarbonate on the market, and the application of this patent can make up for this part of the gap

Method used

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  • A compound preparation containing ilaprazole sodium
  • A compound preparation containing ilaprazole sodium
  • A compound preparation containing ilaprazole sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Prescription Screening

[0012] Ilaprazole Sodium Compound Tablets, Ilaprazole Sodium Tablets, Sodium Bicarbonate Tablets, Aluminum Hydroxide Tablets, Calcium Carbonate Tablets, Omeprazole Compound Tablets, Ilaprazole Sodium and Hydroxide Pharmacological comparative experiment of aluminum compound tablet, ilaprazole sodium and calcium carbonate compound tablet.

[0013] Ilaprazole Sodium and Sodium Bicarbonate Compound Tablet 1 (Prescription 1): Prepared according to Example 4 of this specification;

[0014] Ilaprazole sodium and sodium bicarbonate compound tablet 2 (prescription 2): prepared according to Example 5 of this specification;

[0015] Ilaprazole sodium and sodium bicarbonate compound tablet 3 (prescription 3): prepared according to Example 6 of this manual;

[0016] Ilaprazole sodium and sodium bicarbonate compound tablet 4 (prescription 4): prepared according to Example 7 of this manual;

[0017] Ilaprazole sodium and sodium bicarbonate compound tablet 5...

Embodiment 2

[0034] Preparation of Ilaprazole Sodium and Aluminum Hydroxide Compound Tablets

[0035]

[0036] Preparation method: Take the prescribed amount of ilaprazole sodium, aluminum hydroxide, microcrystalline cellulose, lactose, mannitol, and cross-linked povidone, sieve, mix well, and use an appropriate amount of 8% povidone in 40% ethanol solution Add the above mixture to make soft material, pass through a 20-mesh sieve to granulate, dry at 60°C for 6 hours, granulate with a 20-mesh sieve, add fruit milk essence, magnesium stearate, aspartame, and micro-powdered silica gel, and use a 30-mesh sieve The granules are sized, mixed evenly, and compressed into tablets to obtain the tablet of the present invention.

Embodiment 3

[0038] Preparation of compound tablet of ilaprazole sodium and calcium carbonate

[0039]

[0040] Preparation method: Take the prescribed amount of ilaprazole sodium, calcium carbonate, microcrystalline cellulose, lactose, mannitol, and cross-linked povidone, sieve, mix well, and add an appropriate amount of 8% povidone in 40% ethanol solution The soft material made from the above mixture is granulated through a 20-mesh sieve, dried at 60°C for 6 hours, granulated through a 20-mesh sieve, added fruit milk essence, magnesium stearate, aspartame, and micro-powdered silica gel, and granulated with a 30-mesh sieve. Granules, mixed evenly, and tableted to obtain the tablet of the present invention.

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PUM

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Abstract

The invention relates to the field of pharmaceutic preparations, in particular to a compound preparation containing ilaprazole sodium and a preparation method thereof. The preparation per unit is characterized by comprising 5-20 Mg ilaprazole sodium, 500-1500 sodium bicarbonate and suitable auxiliary materials. The invention also discloses a preparation method of the preparation. The preparation has the advantages of rapid onset and small side effect, and can be used for treating diseases such as hyperchlorhydria, gastroesophageal reflux disease, erosive esophagitis (short-term curative), active gastric ulcer, active duodenal ulcer (short-term curative) and the like.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a compound preparation of ilaprazole sodium and a preparation method thereof. Background technique [0002] Digestive system diseases are common diseases and frequently-occurring diseases. According to statistical data, the incidence of gastrointestinal diseases in the world accounts for about 12% of the population. With the continuous development of social economy and the continuous increase of people's study, work, life and psychological pressure, the incidence of digestive system diseases in our country is also increasing year by year. According to the latest survey by an authoritative organization, the average incidence of digestive system diseases in my country has risen to 15.68% in 2003. Beijing, Shanghai, Guangzhou, Tianjin, Shenzhen and other large cities with relatively developed economies, fierce competition, and high work pressure, The incidence of digestiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4439A61K33/00A61P1/04
Inventor 张平侯雪梅金鑫肖鸿于迎春汪伟明向双
Owner 珠海保税区丽珠合成制药有限公司
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