A compound preparation containing ilaprazole

A technology of ilaprazole compound and compound preparation, which is applied in the field of pharmaceutical preparations, can solve the problems of slow onset of action and serious adverse reactions, and achieve the effect of controlling gastric acid

Active Publication Date: 2016-06-01
珠海保税区丽珠合成制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the adverse reactions are serious and the onset is slow
There is no compound preparation of ilaprazole and sodium bicarbonate on the market, and the application of this patent can make up for this part of the gap

Method used

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  • A compound preparation containing ilaprazole
  • A compound preparation containing ilaprazole
  • A compound preparation containing ilaprazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The screening of embodiment 1 prescription

[0014] Ilaprazole Compound Tablets, Ilaprazole Tablets, Sodium Bicarbonate Tablets, Aluminum Hydroxide Tablets, Calcium Carbonate Tablets, Omeprazole Compound Tablets, Ilaprazole and Aluminum Hydroxide Compound Tablets Pharmacological comparative experiment of drug, ilaprazole and calcium carbonate compound tablet.

[0015] Ilaprazole and sodium bicarbonate compound tablet 1 (prescription 1): prepared according to Example 4 of this manual;

[0016] Ilaprazole and sodium bicarbonate compound tablet 2 (prescription 2): prepared according to Example 5 of this manual;

[0017] Ilaprazole and sodium bicarbonate compound tablet 3 (prescription 3): prepared according to Example 6 of this manual;

[0018] Ilaprazole and sodium bicarbonate compound tablet 4 (prescription 4): prepared according to Example 7 of this manual;

[0019] Ilaprazole and sodium bicarbonate compound tablet 5 (prescription 5): prepared according to Example 8 ...

Embodiment 2

[0035] Preparation of compound tablet of ilaprazole and aluminum hydroxide

[0036]

[0037] Preparation method: Take the prescribed amount of ilaprazole, aluminum hydroxide, microcrystalline cellulose, lactose, mannitol, and cross-linked povidone, sieve, mix well, and add an appropriate amount of 8% povidone in 40% ethanol solution The soft material made from the above mixture is granulated through a 20-mesh sieve, dried at 60°C for 6 hours, granulated through a 20-mesh sieve, added with fruit milk essence, magnesium stearate, aspartame, and micro-powdered silica gel, and granulated with a 30-mesh sieve. Granules, mixed evenly, and tableted to obtain the tablet of the present invention.

Embodiment 3

[0039] Preparation of compound tablet of ilaprazole and calcium carbonate

[0040]

[0041] Preparation method: take the prescription amount of ilaprazole, calcium carbonate, microcrystalline cellulose, lactose, mannitol, crospovidone, sieve, mix evenly, add the above-mentioned 40% ethanol solution with an appropriate amount of 8% povidone The soft material is made from the mixture, granulated through a 20-mesh sieve, dried at 60°C for 6 hours, granulated through a 20-mesh sieve, added with fruit milk essence, magnesium stearate, aspartame, and micro-powdered silica gel, and granulated with a 30-mesh sieve , mixed evenly, and tableted to obtain the tablet of the present invention.

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PUM

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Abstract

The invention relates to a compound preparation containing ilaprazole. The preparation per unit comprises 5-20mg ilaprazole, 500-1500mg sodium bicarbonate and an appropriate amount of auxiliary material. The invention further discloses a preparation method of the preparation. The preparation becomes effective quickly, is small in side effect, and is used for treating diseases such as hyperacidity, a gastroesophageal reflux disease, erosive esophagitis, an active gastric ulcer and an active duodenal ulcer (serving as a short-term therapeutic drug).

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a compound preparation of ilaprazole. Background technique [0002] Digestive system diseases are common diseases and frequently-occurring diseases. According to statistical data, the incidence of gastrointestinal diseases in the world accounts for about 12% of the population. With the continuous development of social economy and the continuous increase of people's study, work, life and psychological pressure, the incidence of digestive system diseases in our country is also increasing year by year. According to the latest survey by an authoritative organization, the average incidence of digestive system diseases in my country has risen to 15.68% in 2003. Beijing, Shanghai, Guangzhou, Tianjin, Shenzhen and other large cities with relatively developed economies, fierce competition, and high work pressure, The incidence of digestive system diseases is as high as 31%. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4439A61P1/04A61K33/00
Inventor 侯雪梅金鑫肖鸿于迎春张平汪伟明向双
Owner 珠海保税区丽珠合成制药有限公司
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