Olprinone hydrochloric acid crystal form and preparation method thereof

Abstract

The invention belongs to the chemical field of medicaments, and relates to an Olprinone hydrochloric acid crystal form shown in a structural formula I and a preparation method thereof. Olprinone hydrochloric acid is dissolved into purified water for warming until the temperature is 100 DEG C, reflux is performed and crystallization is performed by reducing temperature to prepare the Olprinone hydrochloric acid crystal form. The Olprinone hydrochloric acid crystal form provided by the invention has the advantages of stable crystal form, insensitivity to temperature, air and light, and convenient long-term storage.

Description

technical field The invention relates to a crystal form of oprenone hydrochloride and a preparation method thereof, belonging to the field of medicinal chemistry. Background technique Oprinone hydrochloride is a known compound with the chemical name 1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridine Forminonitrile hydrochloride monohydrate, as described in structural formula I: Oprinone hydrochloride is a selective phosphodiesterase (PDE) III inhibitor, which is clinically used to treat acute heart failure. It has the effect of enhancing myocardial contractility and dilating blood vessels. , to increase the concentration of cyclic adenosine monophosphate in myocardial cells, increase the level of intracellular calcium ions, strengthen myocardial contractility, and increase cardiac output. CN86102812A discloses the therapeutic use of octogenone and its pharmaceutically acceptable salt, and the preparation method of octogenone hydrochloride. At present, ...

AI Technical Summary

Problems solved by technology

At present, there is no literature disclosing the crystal form of Oprinone Hydrochloride

Images