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Application of Dendrobium officinale polysaccharide in preparation of medicine for preventing and treating hypertension and apoplexy

A technology of Dendrobium officinale polysaccharide and Dendrobium officinale can be applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., which can solve the problems such as water extracts of Dendrobium officinale that have not been discussed in depth, achieve a large dose-response range, ease and lasting blood pressure, and medicinal effect. quick effect

Active Publication Date: 2010-10-06
ZHEJIANG TIANHUANG MEDICINAL PLANT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But even in this document, there is no in-depth discussion of what active ingredients in the water extract of Dendrobium officinale have medicinal effects on cardiovascular and cerebrovascular diseases, or how to further discuss the application value of the active ingredients in the prevention and treatment of hypertension and stroke. reveal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0046] 1. Materials and methods of animal experiments:

[0047] 1. Dendrobium officinale polysaccharide: provided by Zhejiang Tianhuang Pharmaceutical Co., Ltd.

[0048] 2. Hypertensive animal model rats: stroke-prone spontaneously hypertensive rats (SHR-sp) were used. SHR-sp is similar to severe hypertension in the human body, the disease develops rapidly and is prone to stroke. SHR-sp is obtained from the offspring of SHR who died of stroke through inbreeding selection. Without additional incentives (common diet feeding), stroke can occur within 9 to 13 months, and the incidence rate can be as high as 90%. The pathological changes in the occurrence and development of hypertension and stroke are similar to those of humans, and can better reflect the effects of drugs (on the human body). The above models were provided by the Shanghai Animal Center of the Chinese Academy of Sciences. Animals in each group were tested at the age of 10 weeks, and both sexes were used. Clean-g...

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Abstract

The invention relates to preparation and application of Dendrobium officinale, aiming to provide preparation of a medicine using Dendrobium officinale polysaccharide as a drug effective component, and application of the medicine for preventing or treating hypertension and apoplexy. The invention discloses the application of Dendrobium officinale in preparation of the medicine for preventing and treating hypertension or apoplexy, and extract, granules, tablets, capsules and oral liquid based on the polysaccharide and preparation methods thereof. The invention proves that the Dendrobium officinale polysaccharide is the effective component of Dendrobium officinale in preventing and treating cardiovascular and cerebrovascular diseases. By using the Dendrobium officinale polysaccharide as the special-purpose medicine, compared with Dendrobium officinale which is not extracted, the Dendrobium officinale polysaccharide has the advantages of quick medicine efficacy, large dose effect range and obvious effect.

Description

technical field [0001] The present invention relates to the preparation and application of Dendrobium officinale, in particular to the preparation of medicines with Dendrobium officinale polysaccharides as medicinal ingredients, and its application in medicines for preventing or treating hypertension and stroke. Background technique [0002] Hypertension is a common high incidence, and the prevalence rate is increasing year by year. At present, there are about 200 million hypertensive patients in my country. With the acceleration of the pace of life, changes in dietary structure, and lack of exercise, the age of onset is advancing year by year, and the incidence is further increasing. As the disease progresses, high blood pressure often damages important vital organs such as the brain, heart, and kidneys, leading to functional changes and organic damage, and even disability and death. Stroke is one of the severe hypertensive organ damages. Among the current Chinese and West...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K9/06A61K9/16A61K9/48A61K9/20A61K9/08A61K9/14A61P9/12A61P9/10
Inventor 陈立钻楼正家吴人照杨兵勋张旭峰杨芳亮夏克中沈春香陈午兵王增陈宇郑纯威李端阳
Owner ZHEJIANG TIANHUANG MEDICINAL PLANT PHARMA
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