Preparation method of Xiaojiean extract

Abstract

The invention relates to a preparation method of a Chinese complex prescription extract. The extract in the preparation method of the Xiaojiean extract is prepared from the following raw materials in parts by weight: 1100 parts of leatherleaf mahonia, 750 parts of evodia lepta, 750 parts of motherwort, 750 parts of spatholobus stem, 900 parts of glabrous greenbrier rhizome and 750 parts of forsythia suspense. The preparation method comprises the following steps of: (1) taking and making the leatherleaf mahonia, the evodia lepta, the motherwort, the spatholobus stem, the glabrous greenbrier rhizome and the forsythia suspense into net herbs; (2) weighting the leatherleaf mahonia, the evodia lepta and the motherwort, refluxing for extracting by adding 4-12 times (V/W) of 50-95% ethanol 2-4 times for 1-4 h every time, filtering to obtain an extracting solution, reducing the pressure of the extracting solution for recycling the ethanol, and condensing into thick paste, drying and crushing; (3) weighting the spatholobus, the glabrous greenbrier rhizome and the forsythia suspense, refluxing for extracting by adding 4-12 times (V/W) of 50-95% ethanol 2-4 times for 1-4 h every time, filtering to obtain an extracting solution, reducing the pressure of the extracting solution for recycling the ethanol, condensing into thick paste, drying and crushing; and (4) evenly mixing the products obtained in the step (2) and the step (3) to obtain the extract.

Description

technical field [0001] The invention relates to a preparation method of an extract of a traditional Chinese medicine compound preparation. Background technique [0002] Xiaojie'an (formerly known as Rupi'anxiao) is a traditional Chinese medicine compound preparation composed of six medicinal materials such as Gongluomu, Sanchaku, Leonurus, Mildew Spatholobus, Smilax Smilax, and Forsythia, including capsules, oral liquids and other dosage forms. Xiaojie'an The current national drug standards for capsules are recorded in the "National Compilation of Chinese Patent Medicine Standards" Landmark Upgrade National Standard Oral Oncology Pediatrics Subvolume (411-414 pages), standard number: WS-10433(ZD-0433)-2002, and the current national standards for Xiaojie'an Oral Liquid The drug standards are recorded in the "National Compilation of Chinese Patent Medicine Standards" Landmark National Standard Oral Oncology Pediatric Volume (415-418 pages), standard number: WS-10646(ZD-0646)-2...

AI Technical Summary

Problems solved by technology

Taking Xiaojie'an Capsules as an example, the above-mentioned current national drug standards stipulate that each capsule of Xiaojie'an Capsules shall contain no less than 0.03mg of berberine hydrochloride, while the actual content of berberine hydrochloride in each capsule of Xiaojie'an Capsules is generally 0.05-0.10mg Each Xiaojie'an capsule is equivalent to 1100mg of Gonglaomu medicinal material. Based on the Chinese Pharmacopoeia 2005 edition, the content of berberine hydrochloride in Gongluomu should not be less than 0.20%, and the transfer rate of berberine hydrochloride in the above method is only above 1.4%. , generally between 3.5 and 5.5%, compared with the general technical requirement that the active ingredient transfer rate should reach more than 50%, this transfer rate is quite low

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