Novel sustained-release transdermal medicament delivery system

A slow-release transdermal and drug delivery system technology, applied in the digestive system, pharmaceutical formulations, drug combinations, etc., can solve the problems of low therapeutic effect and achieve the effect of reducing irritation and pain relief

Active Publication Date: 2010-12-22
BEIJING YISCON TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After being compatible with multiple active drugs, it is made into a compound preparation, so as to overcome the problem of low therapeutic effect in single preparations

Method used

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  • Novel sustained-release transdermal medicament delivery system
  • Novel sustained-release transdermal medicament delivery system
  • Novel sustained-release transdermal medicament delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Dissolve 1.0 g of povidone and 0.5 g of hydroxyethylcellulose in 75 g of purified water. Dissolve 0.05 g of punocaine and 0.05 g of metronidazole in 25 g of purified water, and decolorize with activated carbon. After filtration, 0.005 g of sodium benzoate was added. Mix with the high molecular polymer solution, and adjust the pH value of the solution to 6.5 with 0.1N NaOH solution. The prepared solution was transferred to the tray and the height of the solution was about 1 cm. After freeze-drying, a cotton-like xerogel can be obtained (see Table 1 for specific prescription). The obtained freeze-dried product can be cut into different sizes and shapes to meet different treatment requirements.

[0038] Table 1

[0039]

Embodiment 2

[0041] Similar to the method of Example 1, there is no preservative in the prescription of Example 2. The purpose of adding preservatives is to prolong the shelf life of the preparation. Since the preparation is a low-density porous xerogel and has very good elasticity, it can be conveniently sterilized by ultraviolet lamp irradiation or radiation irradiation. Therefore, no preservatives are added to the optimized prescription (see Table 2 for the specific prescription).

[0042] Form 2

[0043]

Embodiment 3

[0045] Dissolve 1.0 g of povidone and 0.5 g of hydroxyethylcellulose in 75 g of purified water. Dissolve 0.10 g of honeysuckle extract in 25 g of purified water and decolorize with activated carbon. After filtration, 0.005 g of sodium benzoate, 0.005 g of procaine and 0.005 g of metronidazole were added. Mix with the high molecular polymer solution, and adjust the pH value of the solution to 6.5 with 0.1N NaOH solution. The prepared solution was transferred to the tray and the height of the solution was about 1 cm. After freeze-drying, a cotton-like xerogel can be obtained (see Table 3 for specific prescription). In this example, a local anesthetic (procaine) was added to reduce the patient's pain perception. Anti-inflammatory drugs (metronidazole) are used to enhance the efficacy and shorten the course of treatment.

[0046] Form 3

[0047]

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PUM

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Abstract

The invention discloses a novel sustained-release transdermal medicament delivery system for treating ulcer and wound surface. The system contains an auxiliary material with a biological adhesion effect. The system is a dry gel preparation prepared by blending the auxiliary material and an active medicament and then performing freeze drying on the mixture. After being hydrated on the ulcer and the wound surface, the preparation tightly contacts the ulcer and the wound surface, so that the residence time of the medicament on the ulcer and the wound surface is obviously prolonged and the treatment effect of the medicament is fully brought into full play; at the same time, the preparation has good elasticity and flexibility, so that the preparation inosculates with the biological curve of the ulcer or the wound surface; and after being hydrated, the preparation is formed into a gel and the active medicament dispersed in the gel is slowly released onto an action part, so that the action time of the medicament is prolonged. At the same time, the gel formed after the medicament is hydrated plays a role in isolating and protecting the wound surface and can quicken the concrescence of the wound surface. The preparation is small and light, has no foreign body sensation and peculiar smell and is suitable for all patients.

Description

technical field [0001] This invention belongs to the research of a new type of drug delivery system, and relates to the application of a new type of slow-release transdermal drug delivery system in the field of medicine, especially a kind of polymer material with bioadhesive effect as a carrier and prepared by a freeze-drying process. sustained-release transdermal drug delivery system. Background technique [0002] Oral ulcer is a clinically very common oral mucosal disease, also known as aphthous ulcer. The pain is very obvious during the attack, and it can heal without treatment. Also have recurrent exerbation, are called recurrent oral ulceration, have caused very big impact to patient's work and life. The prevalence rate of oral ulcers in the crowd is generally believed to be 10-30%, which can occur in men, women, old and young, and is most common in young and middle-aged people. Oral ulcers can occur in any part of the oral mucosa, more common on the lips, cheeks, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/32A61K47/34A61K47/36A61K47/38A61K45/00A61P1/02A61K47/10
Inventor 郭旻彤苗文芳包海英杨超莲
Owner BEIJING YISCON TECH
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