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Application of taurine and pharmaceutically acceptable salt thereof to preparing uterine contraction inhibition drug

A technique for uterine contraction and taurine, which is used in food preparation, drug combination, biochemical equipment and methods, etc.

Active Publication Date: 2011-01-26
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no reports of taurine being used in pregnant women and animals as a tocolytic and health care product at home and abroad so far.

Method used

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  • Application of taurine and pharmaceutically acceptable salt thereof to preparing uterine contraction inhibition drug
  • Application of taurine and pharmaceutically acceptable salt thereof to preparing uterine contraction inhibition drug
  • Application of taurine and pharmaceutically acceptable salt thereof to preparing uterine contraction inhibition drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, taurine is used for the preparation of tocolytic medicine or the health product that protects pregnant woman and / or fetal normal development during pregnancy

[0017] 1) Effect of taurine on embryonic development in vitro

[0018] The well-developed fertilized eggs of Kunming mice were transferred into the overnight equilibrium containing different final concentrations of taurine (0mM, 5mM, 10mM), 10mM taurine and 10mM β-alanine (taurine transport inhibitor), 10mM β -In the mKSOM culture fluid of alanine (see Table 1 for the composition of the mKSOM culture fluid culture fluid), put 6~10 fertilized eggs in each drop of culture fluid, place 37 ℃, 5% CO 2 Cultivate to the blastocyst stage in an incubator with saturated humidity, and count the blastocyst rate after culturing for 112 hours. The blastocysts were stained with Hochest 33342 (5μg / ml), and the total number of blastocyst cells was counted to evaluate the effect of taurine on the in vitro developmen...

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Abstract

The invention discloses novel application of taurine and a pharmaceutically acceptable salt thereof to preparing a tocolytic agent or a health product for protecting a pregnant woman and / or normal development of a fetus. The taurine or the pharmaceutically acceptable salt fulfills the regulation function of smooth muscle contraction of mother uterusn, is beneficial to the reducing of early abortin and has the advantages of low cost, good effect without side drug effects.

Description

technical field [0001] The present invention relates to the new medical field of taurine, in particular to the use of taurine and its pharmaceutically acceptable salts in the preparation of drugs for inhibiting uterine contraction, as well as the use of taurine and health care products in human pregnancy and its improvement in human The application of assisted reproductive efficiency. Background technique [0002] At present, there are very few anti-fetal drugs and health products for pregnant women in the domestic market. The international reproductive medicine community is paying more and more attention to the new uses of some important nutrients. For example, Japan is mandating "folic acid + biotin" as oral nutrients for pregnant women in the country. [0003] The chemical name of taurine is 2-aminoethanesulfonic acid (Taurine, abbreviated as Tau), commonly known as taurine, taurine, etc. It is named after it was first isolated from ox bile. Taurine has the highest cont...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61P15/06C12N5/06A23L1/29A23L33/00
Inventor 崔胜范晶晶刘佳利罗昊澍
Owner CHINA AGRI UNIV
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