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Full-automatic LCT (Liquid Cytologic Test) liquid-based thin-layer cell and cell DNA rapid slice production and dyeing integrated machine

A thin-layer cell and fully automatic technology, applied in the preparation of test samples, etc., can solve the problems of cell DNA quantitative ploidy analysis report lag, cell DNA preparation and staining lag, and the quality of preparation is difficult to stabilize, etc., to achieve batch Large, consistent quality, evenly distributed effects

Inactive Publication Date: 2011-01-26
王珑
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, cell DNA production and staining are still mainly done by hand; not only is the efficiency low, but the quality of production is also difficult to stabilize
The lag of cell DNA preparation and staining leads to the lag of cell DNA quantitative ploidy analysis report

Method used

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  • Full-automatic LCT (Liquid Cytologic Test) liquid-based thin-layer cell and cell DNA rapid slice production and dyeing integrated machine
  • Full-automatic LCT (Liquid Cytologic Test) liquid-based thin-layer cell and cell DNA rapid slice production and dyeing integrated machine
  • Full-automatic LCT (Liquid Cytologic Test) liquid-based thin-layer cell and cell DNA rapid slice production and dyeing integrated machine

Examples

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Embodiment Construction

[0029] The circular revolving track 5 is a double track with the same center, the inner track has 64 slide rack holders, and the outer track has 72 slide rack holders. There are 136 positions of the sample chamber 3 and the suction pipe holder 12 on the liquid filling cover 11 of the sample chamber, and the suction nozzle 22 is installed on the suction pipe holder 12 . The left suction nozzle warehouse 1 and the right suction nozzle warehouse 8 are respectively provided with 272 positions, and the suction nozzles 22 are installed in the positions. Film making and dyeing process of the present invention are as follows:

[0030] Sampling pretreatment: After sampling with a cervical brush, store the collected cells in a preservation solution bottle, add an appropriate amount of 0.1% DTT (dithiothreitol) digestion solution, and then label it with a name for use. After a certain number of samples have been collected, shake the above-mentioned sample preservation solution bottle wi...

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Abstract

The invention discloses a full-automatic LCT (Liquid Cytologic Test) liquid-based thin-layer cell and cell DNA rapid slice production and dyeing integrated machine. The slice production and dyeing integrated machine is placed in a box body, a centrifugal device and an annular rotating orbit share the same circle center and are arranged in the same horizontal position, and a sample bin liquid-adding cap and an annular orbit liquid-adding cap are respectively arranged above the centrifugal device and the annular rotating orbit; four mechanical arms and two suction nozzle bins are symmetrically arranged in a space between the centrifugal device and the annular rotating orbit. The invention can complete sample treatment, slice production and dyeing in one machine at one time. The prepared sample slice has stable quality, complete cell and uniform distribution. Moreover, the rapid slice production and dyeing of sample LCT liquid-based thin-layer cell and cell DNA can be realized simultaneously on the same machine. The machine has large-scale sample processing and high efficiency, and is especially applicable to large-scale cancer prevention census and the clinical diagnosis and screening of large special hospitals.

Description

technical field [0001] The invention relates to a liquid-based thin-layer cell and cell DNA preparation and staining device, in particular to a full-automatic LCT liquid-based thin-layer cell and cell DNA rapid preparation and staining machine. technical background [0002] Among the detection methods of human exfoliated cytology anti-cancer screening and early diagnosis, the method of cervical exfoliated cytology detection and screening for early cervical cancer and precancerous lesions is particularly important. The operation method is as follows: use a cervical brush to collect materials and put them into the preservation solution bottle, and after the samples are made into cell suspensions on the machine, they are divided into two groups for liquid-based cell preparation and staining, and cell DNA thin-layer preparation and staining. In addition, pathological sections or frozen sections can also be directly used for cell DNA staining. After the stained cell membranes we...

Claims

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Application Information

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IPC IPC(8): G01N1/28G01N1/31
Inventor 王珑谢爱华王伊超
Owner 王珑
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